DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment REG and PSME3

DIOPT Version :9

Sequence 1:	NP_001259502.1	Gene:	REG / 32274	FlyBaseID:	FBgn0029133	Length:	245	Species:	Drosophila melanogaster
Sequence 2:	NP_789839.1	Gene:	PSME3 / 10197	HGNCID:	9570	Length:	267	Species:	Homo sapiens

Alignment Length:	255	Identity:	118/255 - (46%)
Similarity:	178/255 - (69%)	Gaps:	16/255 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VKVQEYKDSLILKAELLITKGFPENIVRLNELLATPIFNERNFEEVHQDLNIPVLPPLLVKNELE 71
            :||..:::.:..:||.|:...||:.::.|:..|..||.|..:..::|.|:|:||..|:|:.|..:
Human    13 LKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHSDMNLPVPDPILLTNSHD 77

  Fly    72 DRDSLPTKRQRVD---VIVSGQPVMGLPAGTVPCNKPLCEMIKVVKPIIRKLVEDSNL------- 126
            ..|....|::|:|   ....|..|..:|.|.:..|:.|.::|:.|||.||.|:|..|.
Human    78 GLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTPSGKGPH 142

  Fly   127 ------LKMWISFMIPKIEDGNNFGVSIQEDTLAEIQTVESEAAAFFDQISRYFLSRAKVVSKVA 185
                  :|||:..:||:|||||||||||||:|:||::|||||||::.||||||:::|||:|||:|
Human   143 ICFDLQVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQISRYYITRAKLVSKIA 207

  Fly   186 KYPHIDDYRRAVVELDEKEYLSLWLVVCEVRNRYSSLHDIVIKNLEKLKKPRSSNTESLY 245
            ||||::||||.|.|:|||||:||.|::.|:||:|.:|||:::||:||:|:|||||.|:||
Human   208 KYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIEKIKRPRSSNAETLY 267

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
REG	NP_001259502.1	PA28_alpha	5..60	CDD:280421	15/52 (29%)
REG	NP_001259502.1	PA28_beta	102..243	CDD:280422	87/153 (57%)
PSME3	NP_789839.1	PA28_alpha	12..68	CDD:308067	17/54 (31%)
PSME3	NP_789839.1	PA28_beta	108..265	CDD:308068	87/156 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158103
Domainoid	1	1.000	199	1.000	Domainoid score	I3066
eggNOG	1	0.900	-	-		E1_KOG4470
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2111
Inparanoid	1	1.050	255	1.000	Inparanoid score	I3185
Isobase	1	0.950	-	0	Normalized mean entropy	S2675
OMA	1	1.010	-	-		QHG56008
OrthoDB	1	1.010	-	-		D1251022at2759
OrthoFinder	1	1.000	-	-		FOG0007262
OrthoInspector	1	1.000	-	-		oto88733
orthoMCL	1	0.900	-	-		OOG6_104507
Panther	1	1.100	-	-	LDO	PTHR10660
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4154
SonicParanoid	1	1.000	-	-		X5366
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750