DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sno and EMB1135

DIOPT Version :9

Sequence 1:	NP_001096967.1	Gene:	sno / 32273	FlyBaseID:	FBgn0265630	Length:	1653	Species:	Drosophila melanogaster
Sequence 2:	NP_178053.4	Gene:	EMB1135 / 844273	AraportID:	AT1G79350	Length:	1295	Species:	Arabidopsis thaliana

Alignment Length:	1468	Identity:	549/1468 - (37%)
Similarity:	769/1468 - (52%)	Gaps:	255/1468 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   241 PPPPPPSTAANSVRHSPTGGIPNPGGNF----FGGSAAASTSASAANFNMAASLLAQMSYAGGAS 301
            ||||.|:..     ||..||:..  |:.    .|.............|:.....|.||......|
plant     8 PPPPLPAQP-----HSAAGGVIR--GDVQVRCAGCRVILRVKTGVVEFSCPTCQLPQMLPPELLS 65

  Fly   302 QIRALKVAGNIGGVGNNQKPP-PIATTPGS--------GGPAGGAPGSGVKGNNSMMEAVQKLIA 357
            :.|.....       :.|:|| ||.|.|..        ..|....|..|:......:........
plant    66 RARPQFPQ-------SPQQPPQPIQTLPPPIQQQLKPLNLPRPPVPAHGIDPTKMQLPCANCQAI 123

  Fly   358 MN-PEYLTS-GIPNTVFQMFM------------QSMQRPQATPSPNQPMNPGAMVTSAAAAAAHA 408
            :| |..||. ..|....::.:            ||...|....:|..|..|.....:..|..
plant   124 LNVPHGLTRFSCPQCHVELAVDVSKLNRSLTASQSHSNPPTPAAPTVPPPPPPEEVNEEAIE--- 185

  Fly   409 SAVAYVQQEEDEVDYEEMGVA-ETYADYWPAKLKLGKKHPDAVVETASLSSVEPCDVYYKLSLPL 472
                 |::|||     |.|.| ||:.||.|.||.:|..|||.:|||:|||:|:|.:..|.|.:..
plant   186 -----VEREED-----EGGTAGETFMDYRPPKLSIGPPHPDPIVETSSLSAVQPPEPTYDLKIKE 240

  Fly   473 ETINSGHLSALQLESITYASQAHDHLLPDGSRAGFLIGDGAGVGKGRTIAGIIYENYLKGRKKAL 537
            |...|..||.||:|::.||.|.|...|.||:||||.:||||||||||||||:|:||:..||:|||
plant   241 ELERSKALSCLQIETLVYACQRHLQHLADGTRAGFFVGDGAGVGKGRTIAGLIWENWKHGRRKAL 305

  Fly   538 WISVSNDLKYDAERDLSDIGATRIEVHALNKFKYAKISSDVNNNCKRGVIFSTYSALIGESNNKT 602
            |||:.:||||||.|||.|:|||.:.|:.|||..|:|:.|. |...|.||:|.||::||..|.
plant   306 WISIGSDLKYDARRDLDDVGATCVGVNPLNKLPYSKLDSK-NVGIKEGVVFLTYNSLIASSE--- 366

  Fly   603 GKYRSRFRQLLQWCGEDFEGLIIFDECHKAKNLCPVGSGKPTKTGQTVLELQQKLPKARVVYASA 667
             |.|||.:||:||||.:|:||:|||||||||||.|....:||:.||.|:::|.|:|:|||:|.||
plant   367 -KGRSRLQQLVQWCGPEFDGLLIFDECHKAKNLVPEAGSQPTRIGQAVVDIQDKIPQARVIYCSA 430

  Fly   668 TGASEPKNMAYMVRLGLWGQGTAFGNFNDFITAVERRGVGAMEIVAMDMKLRGMYIARQLSFKGV 732
            ||||||:||.|||||||||.||:|.:||.|:.|:::.|.||:|:||||||.||||:.|.||:||.
plant   431 TGASEPRNMGYMVRLGLWGAGTSFSDFNKFLGALDKGGTGALELVAMDMKARGMYVCRTLSYKGA 495

  Fly   733 SFKIEEVPLSKEFRKIYDQSVELWVEAMQKFTEAAELIDAESRMKKTMWGQFWSSHQRFFKYLCI 797
            .|:|.|..|......:|::|.|.|.|...:...|:..:..|......:|..:||||||||::||:
plant   496 EFEIVEARLEAGMEAMYNKSAEFWAELRIELLSASAFLPNEKPNSSQLWRLYWSSHQRFFRHLCM 560

  Fly   798 AAKVNHAVLVARESIKYGKCVVIGLQSTGEARTLDQLERDDGELTDFVSTAKGVFQSFVERHFPA 862
            :|||...|.:|::::...|||||||||||||||.:.:.:...||.||||..:.:...|||.::|.
plant   561 SAKVPVTVRLAKKALSTNKCVVIGLQSTGEARTEEAVNKYGLELDDFVSGPRELLLKFVEENYPL 625

  Fly   863 PDRNRINRILGLYDETPSLSSVADSTSSLSNNSNITTAAGKRKGSNNNDNRSTKIKKKKRSGSWE 927
            |             |.|...|..||...|..         ||..::...:...:::|..:   |
plant   626 P-------------EQPEPLSEDDSVKELQR---------KRHSASPGVSIRGRVRKMAK---W- 664

  Fly   928 CSDSEDENTDMKRNRKRDGGNSNSDSDEANSDDDLKSDIDDEDEDHDVDS--DQRSV---ASDAS 987
                           |.|..|.:....||:|.|| .:|.|||.:...:.|  |:|..   .|:..
plant   665 ---------------KPDSDNESDLESEADSADD-SNDSDDEFQICQICSGEDERKKLLHCSECD 713

  Fly   988 SDFNPFFSGSDSDIDPWVNARSKK----SKKAQKKSKKKVKKEKTKKEITTSSATDPSGSTAMSA 1048
            ..|:|     |..:.|.::..|:.    |           .||||::.|
plant   714 KLFHP-----DCVVPPVIDLPSEAWICFS-----------CKEKTEEYI---------------- 746

  Fly  1049 TVVAALNAVKNRKSQLSTQDKIQDLLQKKQELKGTVTPVGVNGVKLNYGPPPKDAIERACTMKEE 1113
                     :.|:..::.       |||:.|.                      |:||    |.:
plant   747 ---------QARRLYIAE-------LQKRYEA----------------------ALER----KSK 769

  Fly  1114 LLRKIERLGARLPPNTLDQLIDELGGPDNVAEMTGRRGRVVQTDDG-SIQYESRTESDVPLETLN 1177
            ::..|..|  .||.|.||.::|:||||:.|||||||||.:|:..:| .:.|::|...|:.:|.:|
plant   770 IIEIIRSL--NLPNNPLDDIVDQLGGPEKVAEMTGRRGMLVRASNGKGVTYQARNTKDITMEMVN 832

  Fly  1178 ITEKQRFMDGEKDVAIISEAASSGISLQSDRRVFNQRRRVHITLELPWSADRAIQQFGRTHRSNQ 1242
            :.|||.||||:|.|||||||.|:|:|||:|||..||:||||:|||||||||||||||||||||||
plant   833 MHEKQLFMDGKKLVAIISEAGSAGVSLQADRRAVNQKRRVHLTLELPWSADRAIQQFGRTHRSNQ 897

  Fly  1243 VNAPEYIFLISDLAGERRFASTVAKRLESLGALTHGDRRATET-RDLSQFNIDNKYGRQALETVM 1306
            .:||||..|.::|.|||||||.||||||:|||||.|||||..: ..||.:|.|:.:|:::|..:.
plant   898 TSAPEYRLLFTNLGGERRFASIVAKRLETLGALTQGDRRAGPSGPSLSAYNYDSNFGKKSLMVMY 962

  Fly  1307 RTIMGYES-PLVPP-----PTDYSGEFFKDIAGALVGVGIIVNSESHPGVLS------------L 1353
            |.||..|. |::||     ..:...||......|||.|||:.:|     ||:            :
plant   963 RGIMEQEKLPVLPPGCSIDEPETVKEFLTKARAALVAVGIVRDS-----VLANGKDVGRFSGRII 1022

  Fly  1354 DKDYNNISKFLNRILGCPVDLQNRLFKYFTDTMTAIIQQAKRGGRFDLGILDLGAAGENVTRVRL 1418
            |.|.:::.:||||:||.|.|:|||||:.||..:..::..|:..|.||.||:|:.|  .:|..:..
plant  1023 DSDMHDVGRFLNRLLGLPPDIQNRLFELFTSILDVLVHNARIEGSFDSGIVDMKA--NSVELLST 1085

  Fly  1419 IRFVRKHATGVAPTEMHTVRVERGMIWQEAID----KYAD-LFNENEGFYLSHQLRNQKRTAIMV 1478
            .:.|.......|.|.:.|..::||:.|:.|..    |..| |.:.|:||:.|.:....:|..|:.
plant  1086 PKTVHVDQMSGASTMLFTFTLDRGVTWESASSMLEGKRRDGLGSANDGFFESKREWLGRRHFILA 1150

  Fly  1479 VILESRNSSSTSSTTDLDSGSKKKKTHSKKEIMCQIYRPNTGLQVRHESLFELEKKYRKVAS-EE 1542
              .||..|.                       :.:|.||..|..:|..||.||:.||||::| |:
plant  1151 --FESAASG-----------------------LFKIVRPAVGESIREMSLSELKTKYRKLSSLEK 1190

  Fly  1543 AEPHWTEQYDASVNTCSHAYWNGNCRNVSLGNDCEVGLRQRLYHVLAGSVLSVWGRVEHILNTR- 1606
            |...|.::|:.|...|.|   ...|:   ||..|.||.|.:..:|:.|.:|.:||.:|..|:.:
plant  1191 ARTGWEDEYEVSSKQCMH---GPKCK---LGEYCTVGRRIQEVNVVGGLILPIWGTIEKALSKQA 1249

  Fly  1607 --SNSKMQVIRMK-TTEGEKIVGTLIPKSCFEPLVADL 1641
              |:.:::|||:: ||:.::|||..||.:..|.::.||
plant  1250 RHSHKRIRVIRIETTTDNQRIVGLSIPNAAVETVLQDL 1287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sno	NP_001096967.1	AAA_34	448..751	CDD:290583	171/302 (57%)
sno	NP_001096967.1	Helicase_C_4	1128..1405	CDD:290582	152/296 (51%)
EMB1135	NP_178053.4	AAA_34	216..514	CDD:290583	171/302 (57%)
		PHD	693..741	CDD:279022	11/63 (17%)
		DUF349	739..>791	CDD:281922	22/111 (20%)
		Helicase_C_4	782..1074	CDD:290582	152/296 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	356	1.000	Domainoid score	I204
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10055
Inparanoid	1	1.050	836	1.000	Inparanoid score	I73
OMA	1	1.010	-	-		QHG59957
OrthoDB	1	1.010	-	-		D141580at2759
OrthoFinder	1	1.000	-	-		FOG0002373
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102140
Panther	1	1.100	-	-	LDO	PTHR12706
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1569
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.980