DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sno and SBNO2

DIOPT Version :9

Sequence 1:	NP_001096967.1	Gene:	sno / 32273	FlyBaseID:	FBgn0265630	Length:	1653	Species:	Drosophila melanogaster
Sequence 2:	NP_055778.2	Gene:	SBNO2 / 22904	HGNCID:	29158	Length:	1366	Species:	Homo sapiens

Alignment Length:	1468	Identity:	618/1468 - (42%)
Similarity:	820/1468 - (55%)	Gaps:	328/1468 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   241 PPP-------PPPSTAANSVRHSPTGGIPNPGGNFFGGSAAASTSASAANFNMAASLLAQM---- 294
            |||       |||..:|  :.|.|.       .|.|......:.|:.:..|..:||.|...
Human    17 PPPAGSLLYSPPPLQSA--MLHCPY-------WNTFSLPPYPAFSSDSRPFMSSASFLGSQPCPD 72

  Fly   295 -SYAGGASQIRALKVAGNIGGVGNNQKPPPIATTPGSGGPAGGAPG---------------SGVK 343
             |||                         |:||       |...|.               |.:.
Human    73 TSYA-------------------------PVAT-------ASSLPPKTCDFAQDSSYFEDFSNIS 105

  Fly   344 GNNSMMEAVQKLIAMNPEYLTSG-------------IPNTVFQMFMQSMQRPQA-----TPSPNQ 390
            ..:|.::::..::. .|::|.:.             .|:|..::|  .:.||.|     .||.:.
Human   106 IFSSSVDSLSDIVD-TPDFLPADSLNQVSTIWDDNPAPSTHDKLF--QLSRPFAGFEDFLPSHST 167

  Fly   391 PMNPGAMVTSAAAAAAHASAVAYVQQ-------EEDEV---DYEEMGVAETYADYWPAKLKLGKK 445
            |:                 .|:|.:|       ||||.   :.||:|..||||||.|:|.|:||:
Human   168 PL-----------------LVSYQEQSVQSQPEEEDEAEEEEAEELGHTETYADYVPSKSKIGKQ 215

  Fly   446 HPDAVVETASLSSVEPCDVYYKLSLPLETINSGHLSALQLESITYASQAHDHLLPDGSRAGFLIG 510
            |||.||||::||||.|.|:.|.|:||.:   ||.|||||||:||||.|.|:.|||.|.|||||||
Human   216 HPDRVVETSTLSSVPPPDITYTLALPSD---SGALSALQLEAITYACQQHEVLLPSGQRAGFLIG 277

  Fly   511 DGAGVGKGRTIAGIIYENYLKGRKKALWISVSNDLKYDAERDLSDIGATRIEVHALNKFKYAKIS 575
            ||||||||||:||:|.||:|:|||||||.||||||||||||||.||.||.|.||||:|.||.
Human   278 DGAGVGKGRTVAGVILENHLRGRKKALWFSVSNDLKYDAERDLRDIEATGIAVHALSKIKYG--- 339

  Fly   576 SDVNNNCKRGVIFSTYSALIGESNNKTGKYRSRFRQLLQWCGEDFEGLIIFDECHKAKNLCPVGS 640
               :.....||:|:||||||||| ...|::|:|.||:|.||||.|||:|:|||||||||   .||
Human   340 ---DTTTSEGVLFATYSALIGES-QAGGQHRTRLRQILDWCGEAFEGVIVFDECHKAKN---AGS 397

  Fly   641 GKPTKTGQTVLELQQKLPKARVVYASATGASEPKNMAYMVRLGLWGQGTAFGNFNDFITAVERRG 705
               ||.|:.||:||.|||.||||||||||||||:||.||.|||:||:||.|.||.:|:.|:|:||
Human   398 ---TKMGKAVLDLQNKLPLARVVYASATGASEPRNMIYMSRLGIWGEGTPFRNFEEFLHAIEKRG 459

  Fly   706 VGAMEIVAMDMKLRGMYIARQLSFKGVSFKIEEVPLSKEFRKIYDQSVELWVEAMQKFTEAAELI 770
            ||||||||||||:.||||||||||.||:|:|||:||:..|..:|:::..||.||:..|.:||:.|
Human   460 VGAMEIVAMDMKVSGMYIARQLSFSGVTFRIEEIPLAPAFECVYNRAALLWAEALNVFQQAADWI 524

  Fly   771 DAESRMKKTMWGQFWSSHQRFFKYLCIAAKVNHAVLVARESIKYGKCVVIGLQSTGEARTLDQLE 835
            ..|||  |::||||||:||||||||||||||...|.:|||.:...|||||||||||||||.:.|.
Human   525 GLESR--KSLWGQFWSAHQRFFKYLCIAAKVRRLVELAREELARDKCVVIGLQSTGEARTREVLG 587

  Fly   836 RDDGELTDFVSTAKGVFQSFVERHFPAPDRNRINRILGLYDETPSLSSVADSTSSLSNNSNITTA 900
            .:||.|..|||.|:|||.|.:::|||
Human   588 ENDGHLNCFVSAAEGVFLSLIQKHFP--------------------------------------- 613

  Fly   901 AGKRKGSNNNDNRSTKIKKKKRSGSWECSDSEDENTDMKRNRKRDGGNSNSDSDEANSDDDLKSD 965
                         |||.|:.:.:||             ||.|:..|..:.:......:...::
Human   614 -------------STKRKRDRGAGS-------------KRKRRPRGRGAKAPRLACETAGVIR-- 650

  Fly   966 IDDEDEDHDVDSDQRSVASDASSDFNPFFSGSDSDIDPWVNARSKKSKKAQKKSKKKVKKEKTKK 1030
                            ::.|:|::.:|   |.|||.:
Human   651 ----------------ISDDSSTESDP---GLDSDFN---------------------------- 668

  Fly  1031 EITTSSATDPSGSTAMSATVVAALNAVKNRKSQLSTQDKIQDLLQKKQELKGTVTPVGVNGVKLN 1095
                   :.|.........:|.|:....:.:..|.       |||:..
Human   669 -------SSPESLVDDDVVIVDAVGLPSDDRGPLC-------LLQRDP----------------- 702

  Fly  1096 YGPPPKDAIERACTMKEELLRKIERLGARLPPNTLDQLIDELGGPDNVAEMTGRRGRVVQTDDGS 1160
            :||...:.:||   :|::||.|:.|||..||.||||:|||:||||..|||||||:||||...||:
Human   703 HGPGVLERVER---LKQDLLDKVRRLGRELPVNTLDELIDQLGGPQRVAEMTGRKGRVVSRPDGT 764

  Fly  1161 IQYESRTESDVPLETLNITEKQRFMDGEKDVAIISEAASSGISLQSDRRVFNQRRRVHITLELPW 1225
            :.:|||.|..:.::.:|:.||||||.|||.|||||||:|||:|||:||||.|||||||:||||||
Human   765 VAFESRAEQGLSIDHVNLREKQRFMSGEKLVAIISEASSSGVSLQADRRVQNQRRRVHMTLELPW 829

  Fly  1226 SADRAIQQFGRTHRSNQVNAPEYIFLISDLAGERRFASTVAKRLESLGALTHGDRRATETRDLSQ 1290
            ||||||||||||||||||:||||:||||:|||||||||.||||||||||||||||||||:||||:
Human   830 SADRAIQQFGRTHRSNQVSAPEYVFLISELAGERRFASIVAKRLESLGALTHGDRRATESRDLSK 894

  Fly  1291 FNIDNKYGRQALETVMRTIMGYESPLVPPPTDYSG---EFFKDIAGALVGVGIIVNSESHPGVLS 1352
            :|.:||||.:||..|:.||:......||.|..|.|   .||:|:...|:.|| |...||..|.|.
Human   895 YNFENKYGTRALHCVLTTILSQTENKVPVPQGYPGGVPTFFRDMKQGLLSVG-IGGRESRNGCLD 958

  Fly  1353 LDKDYNNISKFLNRILGCPVDLQNRLFKYFTDTMTAIIQQAKRGGRFDLGILDLGAAGENVTRVR 1417
            ::||. :|:||||||||..|..||.||:||:||...:|:..||.|::|:|||||....|.:
Human   959 VEKDC-SITKFLNRILGLEVHKQNALFQYFSDTFDHLIEMDKREGKYDMGILDLAPGIEEI---- 1018

  Fly  1418 LIRFVRKHATGVAP-------TEMHTVRVERGMIWQEAIDKYADLFNENEGFYLSHQLRNQKRTA 1475
               :.......:||       ...:.:.|:||:.|::|..|...|....:|||||:::|..|.:.
Human  1019 ---YEESQQVFLAPGHPQDGQVVFYKISVDRGLKWEDAFAKSLALTGPYDGFYLSYKVRGNKPSC 1080

  Fly  1476 IMVVILESRNSSSTSSTTDLDSGSKKKKTHSKKEIMCQIYRPNTGLQVRHESLFELEKKYRKVAS 1540
            ::..  ::|....|                        :|:||.|.|.:.|:|..|.:|:.:|.:
Human  1081 LLAE--QNRGQFFT------------------------VYKPNIGRQSQLEALDSLRRKFHRVTA 1119

  Fly  1541 EEAEPHWTEQYDASVNTCSHAYWNGNCRNVSLGNDCEVGLRQRLYHVLAGSVLSVWGRVEHIL-N 1604
            |||:..|...|..|:..|||:.||.:||....|.||..|||.|.:::|.|::|.||||:..:: :
Human  1120 EEAKEPWESGYALSLTHCSHSAWNRHCRLAQEGKDCLQGLRLRHHYMLCGALLRVWGRIAAVMAD 1184

  Fly  1605 TRSNSKMQVIRMKTTEGEKIVGTLIPKSCFEPLVADLR 1642
            ..|:|.:|::|:||.:.:|.||..||:.|...::.:||
Human  1185 VSSSSYLQIVRLKTKDRKKQVGIKIPEGCVRRVLQELR 1222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sno	NP_001096967.1	AAA_34	448..751	CDD:290583	202/302 (67%)
sno	NP_001096967.1	Helicase_C_4	1128..1405	CDD:290582	180/279 (65%)
SBNO2	NP_055778.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		3/6 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	174..217		19/42 (45%)
		AAA_34	218..505	CDD:290583	202/302 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	614..640		10/38 (26%)
		Helicase_C_4	732..1010	CDD:290582	180/279 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1324..1366
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158099
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59957
OrthoDB	1	1.010	-	-		D112455at33208
OrthoFinder	1	1.000	-	-		FOG0002373
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102140
Panther	1	1.100	-	-	O	PTHR12706
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10047
SonicParanoid	1	1.000	-	-		X1569
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.890