DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sno and let-765

DIOPT Version :9

Sequence 1:	NP_001096967.1	Gene:	sno / 32273	FlyBaseID:	FBgn0265630	Length:	1653	Species:	Drosophila melanogaster
Sequence 2:	NP_498455.2	Gene:	let-765 / 175934	WormBaseID:	WBGene00002889	Length:	1866	Species:	Caenorhabditis elegans

Alignment Length:	1803	Identity:	713/1803 - (39%)
Similarity:	987/1803 - (54%)	Gaps:	298/1803 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 DDNDNFDEDDSGSDFDDDEDP----------DQIEVPGGGRDLNTAVTYAQNIRS---------- 58
            :.||..::.::.|   |.::|          .:::.|.....::..:|.:...||
Worm   178 EGNDGLEDQETTS---DRQNPMFVQTARSTDGRLDTPSTSATVSPHITSSLTQRSHTSSPASSAS 239

  Fly    59 -GVGVAP-KGGIPIPISG----------------AKIVVGNNKIKPISLLRINNNNNNIVTSVNN 105
             |..|.| |.|:||....                .|..|..|..|...||      :.:..|...
Worm   240 EGTVVPPRKKGLPITTGSIVKRTVQTKDGLQTQYLKAFVNENGEKIYKLL------SPVAASAVA 298

  Fly   106 R--------NNNNIISTNGSSNNNN--------NSINNNSQIIKTTTVTTTPTTVGATPTVGGVA 154
            |        ...:.|...|:..|.|        |.:..|.|::....|:...|.:        ||
Worm   299 RGTLPPGMGRGGSTIGRGGTMVNKNGERLMVVKNHVGPNGQMLVKRMVSPAGTRI--------VA 355

  Fly   155 LGGKLTVIPIAGRNVALDNNLSNMPKKLNNMVTAMGSP--------AARSSGNAGTT-GSSQG-- 208
            .||:....||..   |:|.  ||.|..|....|..|.|        |||.:...||. |...|
Worm   356 NGGQGRGQPIYR---AVDG--SNGPTHLLRRTTTTGQPTRGAPVGMAARHAVRGGTVYGGGNGYR 415

  Fly   209 ------GAIGSTSSY---LNSLTTNELMNLAAYVAAKG---SNAPPPPPPSTAANSVRHSPTGGI 261
                  |..|||..:   ||.:::...:.....|..:|   :.|..|...||::.:..:......
Worm   416 VNLVGRGTGGSTMVHHQPLNRISSQRSVAPVGRVLNRGALRNGAQQPLHVSTSSPAFHYMEEQPS 480

  Fly   262 PNPGGNFFGGSAAASTSASAANFNMAASLLAQMSY-AGGASQIRALKVAGNIG-----GVGNNQK 320
            |...|      .........|....|..:.:|.|: :||.:::...:.:.|.|     |.|.:|:
Worm   481 PTTNG------MVIQAKTPGAGVIQARHMQSQQSFPSGGPARVLMNRSSTNAGLSRMVGGGYDQQ 539

  Fly   321 PPPIATTPGSGGPAGGAPGSGVKGNNSMMEAVQKLIAMNPEYLTSGIPNTVFQMFMQSMQRPQAT 385
            .|   |.|                |..:|                 ||:|..::....|..|:..
Worm   540 LP---TAP----------------NGRLM-----------------IPSTAVRVPGSGMASPRLQ 568

  Fly   386 PSPNQPMNPGAMVTSAAAAAAHASAVAYVQQEEDEV--DYEEMGVAETYADYWPAKLKLGKKHPD 448
            .:| ||:............|........:||..:::  |.|.:|.||||::|.||||:.|..|||
Worm   569 TTP-QPLTKSQKAKDEMKMAYQVGREEALQQRRNDLEDDEENLGYAETYSEYTPAKLRSGMAHPD 632

  Fly   449 AVVETASLSSVEPCDVYYKLSLPLETINSGHLSALQLESITYASQAHDHLLPDGSRAGFLIGDGA 513
            :|||:||||||.|.||.|::|:|...|:.||:||||||::.||.|.|:..:|.|.|.|:||||||
Worm   633 SVVESASLSSVSPPDVKYQISIPEYLIDMGHISALQLEAVIYACQMHERRMPSGERYGYLIGDGA 697

  Fly   514 GVGKGRTIAGIIYENYLKGRKKALWISVSNDLKYDAERDLSDIGATRIEVHALNKFKYAKISSDV 578
            |||||||:|.||:||||:|||:|:|:|||:|||:||||||.|.||..|.|:||||.||||||...
Worm   698 GVGKGRTVACIIFENYLQGRKRAIWLSVSSDLKFDAERDLRDCGAPNIPVYALNKMKYAKISGKE 762

  Fly   579 NNNCKRGVIFSTYSALIGESNN-KTGKYRSRFRQLLQWCGEDFEGLIIFDECHKAKNLCPVGSGK 642
            |.:.|:||:|:||::||||... |:.|||||..||:||.|:|::|:||.||||:||||.|....|
Worm   763 NGSIKKGVMFATYTSLIGECRGAKSRKYRSRISQLIQWFGQDYDGVIILDECHRAKNLVPTAGAK 827

  Fly   643 PTKTGQTVLELQQKLPKARVVYASATGASEPKNMAYMVRLGLWGQGTAFGNFNDFITAVERRGVG 707
            |||||:.|||||:.||.|||||||||||:||:|||||.||||||:..||..|:|||:||||||||
Worm   828 PTKTGRMVLELQKALPNARVVYASATGATEPRNMAYMTRLGLWGERQAFPEFHDFISAVERRGVG 892

  Fly   708 AMEIVAMDMKLRGMYIARQLSFKGVSFKIEEVPLSKEFRKIYDQSVELWVEAMQKFTEAAELIDA 772
            ||||||||||.||:|:||||||:||||.::||.||.||.|:||.:|:||:||.::|....|.:|.
Worm   893 AMEIVAMDMKQRGLYLARQLSFRGVSFAVQEVQLSSEFVKMYDAAVKLWMEARRQFQTVIETMDE 957

  Fly   773 ESRMK-KTMWGQFWSSHQRFFKYLCIAAKVNHAVLVARESIKYGKCVVIGLQSTGEARTLDQLER 836
            |.|.. ||:|||||:.||||||||||||||:..|.::||:||..||||||||||||:.||:.||.
Worm   958 EERSTCKTVWGQFWACHQRFFKYLCIAAKVDTCVQLSREAIKAKKCVVIGLQSTGESATLETLEE 1022

  Fly   837 DDGELTDFVSTAKGVFQSFVERHFPAP------DRNRINRILGLYD--ETPSLSSVADSTSSLSN 893
            ..|||.:||||||.|....:::|||..      ||:    |...:|  |.|:.......|.|...
Worm  1023 MGGELNEFVSTAKTVLYGLIDKHFPTDASFSMGDRD----IFKDFDDFERPAKRRKTRETLSFLG 1083

  Fly   894 N------SNITTAAGKRKG-------------------------SNNNDNRSTKIKKKKRSGSWE 927
            :      :.:||..|.|.|                         :||.|..||      .|.|.:
Worm  1084 DVGFDTWTGVTTGMGGRVGDGVTKNITRGLSGIGRSSMSSSTGNTNNEDANST------TSESSD 1142

  Fly   928 CSDSEDENTDMKRN-----------RKRDGGNSNSDSD------------EANSDDDLKSDIDDE 969
            .||.|.||..:..|           .:.:|..:..|.:            |::|||..:..:.||
Worm  1143 GSDDEVENDMISENGGESGDLESAREEAEGARTLEDGEQDEWVKALLAEAESSSDDSDEEVVKDE 1207

  Fly   970 DEDHDVDSDQRSVASDASSDFNPFFSGSDSDIDPW------VNARSKKSKKAQKKS--------- 1019
            |||.:.:| :.....:...:||||.....:| |||      |....:|.:||:|:.
Worm  1208 DEDEEAES-KSGETHEQEEEFNPFMCDFTND-DPWAHNQQIVEDTPQKDRKAKKRKRDEEEAERL 1270

  Fly  1020 KKKVKKEKTKKEITTSSATDPSGSTAMSATVVAALNAVKNRKSQLSTQDKIQDLLQKKQELKGTV 1084
            ::||:|.:.::|                          |.|:..:...::.:....::.:.:|:.
Worm  1271 REKVRKREERRE--------------------------KKRRRAIRRAEREKQRRNEELQARGSA 1309

  Fly  1085 TPVGVNGVKLNYGPPPKDAIERACTMKEELLRKIERLGARLPPNTLDQLIDELGGPDNVAEMTGR 1149
            |....:......|...:|.| ....:|.|||..:|||...||.|||||||||:|||:.|||||||
Worm  1310 TDFITSSRICGNGSGEQDDI-NPMLIKTELLAAVERLAPSLPANTLDQLIDEMGGPEYVAEMTGR 1373

  Fly  1150 RGRVVQTDDGSIQYESR-TESDVPLETLNITEKQRFMDGEKDVAIISEAASSGISLQSDRRVFNQ 1213
            ||.:|.::.|.:.|:.| ..::|.||.:|:.||::||.|||.:||||||||||||||||||..|:
Worm  1374 RGHMVTSETGDVMYQRRNANAEVSLELINMEEKEKFMRGEKLIAIISEAASSGISLQSDRRAINK 1438

  Fly  1214 RRRVHITLELPWSADRAIQQFGRTHRSNQVNAPEYIFLISDLAGERRFASTVAKRLESLGALTHG 1278
            |||||||||||||||:||||||||||||||:.|||:||||:||||:||||.||||||||||||||
Worm  1439 RRRVHITLELPWSADKAIQQFGRTHRSNQVSGPEYVFLISELAGEKRFASIVAKRLESLGALTHG 1503

  Fly  1279 DRRATETRDLSQFNIDNKYGRQALETVMRTIMGYE-SPLVPPPTDY-SGEFFKDIAGALVGVGII 1341
            ||||||||||||||:||||||.||:|:::|::|.. :||:.||.|| :||||:|:...:.|||::
Worm  1504 DRRATETRDLSQFNMDNKYGRVALDTLLKTVIGQAGTPLIDPPKDYKAGEFFEDMRLYMEGVGLL 1568

  Fly  1342 VNSESHPGVLSLDKDYNNISKFLNRILGCPVDLQNRLFKYFTDTMTAIIQQAKRGGRFDLGILDL 1406
            ..:::  |..:::|:...|.||||||||.||..||.||.||::.:..:|.|:|..|.:|.||:||
Worm  1569 AKNKT--GQYTIEKEAATIPKFLNRILGLPVHAQNSLFHYFSEIVAELIAQSKHDGTYDTGIMDL 1631

  Fly  1407 GAAGENVTRVRLIRFVRKHATGVAPTEMHTVRVERGMIWQEAIDKYADLFNENEGFYLSH----Q 1467
            |...:.|.::....|..:...|....|:|.:.||||:.|:||::.:.:..|:::|||:.|    .
Worm  1632 GTGDDQVRKLETRVFTGRVDNGSFRVEIHKIGVERGVSWEEAMELHKEHSNDDDGFYICHPGGAN 1696

  Fly  1468 LRNQKRTAIMVVILESRNSSSTSSTTDLDSGSKKKKTHSKKEIMCQIYRPNTGLQVRHESLFELE 1532
            ..|.|:.|.:|..:         ....:|:|::          :..|.||:||...:..::.:|.
Worm  1697 TANTKKVAALVYGI---------GKIRMDNGAR----------LYAITRPSTGRSPKLMTMADLS 1742

  Fly  1533 KKYRKVASEEAEPHWTEQYDASVNTCSHAYWNGNCRNVSLGNDCEVGLRQRLYHVLAGSVLSVWG 1597
            |::.||:.:||:..|.:|||::.|.|.|.|..|.||..|.|..||||.|.|.|.||:|||||||.
Worm  1743 KRFHKVSIDEAKEVWKQQYDSAANMCQHNYVYGKCRTESNGTYCEVGRRTRTYFVLSGSVLSVWP 1807

  Fly  1598 RVEHIL--NTRSNSKMQVIRMKTTEGEKIVGTLIPKSCFEPLVADLRS 1643
            .||.:|  :.|.:|:|||||::|.:.:||||.|:..:....||..|.:
Worm  1808 IVEEVLAGSDRKSSRMQVIRVRTEQDQKIVGLLVLPTHVRHLVQQLET 1855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sno	NP_001096967.1	AAA_34	448..751	CDD:290583	202/303 (67%)
sno	NP_001096967.1	Helicase_C_4	1128..1405	CDD:290582	178/279 (64%)
let-765	NP_498455.2	AAA_34	632..936	CDD:372772	202/303 (67%)
let-765	NP_498455.2	Helicase_C_4	1352..1630	CDD:372771	178/279 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167023
Domainoid	1	1.000	421	1.000	Domainoid score	I320
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10055
Inparanoid	1	1.050	1104	1.000	Inparanoid score	I119
Isobase	1	0.950	-	0	Normalized mean entropy	S5061
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D112455at33208
OrthoFinder	1	1.000	-	-		FOG0002373
OrthoInspector	1	1.000	-	-		otm14745
orthoMCL	1	0.900	-	-		OOG6_102140
Panther	1	1.100	-	-	LDO	PTHR12706
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R10047
SonicParanoid	1	1.000	-	-		X1569
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.880