DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12096 and Psmd5

DIOPT Version :9

Sequence 1:	NP_001285190.1	Gene:	CG12096 / 32269	FlyBaseID:	FBgn0030457	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_542121.2	Gene:	Psmd5 / 66998	MGIID:	1914248	Length:	504	Species:	Mus musculus

Alignment Length:	531	Identity:	138/531 - (25%)
Similarity:	243/531 - (45%)	Gaps:	90/531 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 KLKALESKPQ--------------RLDAL-TAMNSAIAKEAALPRQIIERLLTTDQLYDCANPAA 60
            :|:||:|..|              ||..| :.:|....::.||...|:||||
Mouse    21 ELRALQSVVQAVPLHELREQAAELRLRPLFSLLNQNNREQTALCVSILERLL------------- 72

  Fly    61 DSHVPKDQAVDVTLELLCHCLDQLAMDTADEQLSSLLRRGLTHSNPALRAQVLASLFKKLLRQLT 125
                   |||:.     .|....|.:|         |:|||||.:.:::...|:.:.:.:.....
Mouse    73 -------QAVEP-----IHLARNLRLD---------LQRGLTHPDDSVKTLTLSQIGRIVENSEA 116

  Fly   126 VGQVLTLPNNELIFLILDELKQPDTQSTSLAINILSIVLPQRISNADVQA--------KLVQLLK 182
            |.::|.  |.||:..|:..:...:......||..||.:   .::.|.::|        .|..::|
Mouse   117 VTEILN--NAELLKQIVYCIGGENLSVAKAAIKSLSRI---SLTQAGLEALFESNLLDDLKNVMK 176

  Fly   183 QNEIVRCRAYELAVVLAKKSATLLSDVTF--ILDAALSELDNDDVLLQASVMELLVPLAEQNHGL 245
            .|::||.|.|||.:.::..|:..|:..|.  ::...|.||..:|||::|:.:|::..||..:||.
Mouse   177 TNDVVRYRVYELIIDISSVSSESLNYCTTSGLVTQLLKELTGEDVLVRATCIEMVTSLAYTHHGR 241

  Fly   246 SYMERRRVLDIISYRVQRVEEHPLDALLVPSIMKFFGKISVY-QPLKIIGGYPHMLACLFMQLQS 309
            .|:.:..|:|.||..:...:..|.....:|..:||||.::|. .|.:|...||..|..:|....|
Mouse   242 QYLAQEGVIDQISNIIVGADSDPFSGFYLPGFVKFFGNLAVMDSPQQICERYPVFLEKVFEMADS 306

  Fly   310 EDESILPTAMDTLANLATTPQGKILLNMHFSGA-MEKSFKKYGSHTKKLSAHIKKRLLNSL-DVI 372
            :|.:::..|:||:..|.::.:||.:|..  :|. .|:...:.|...|..|..:|.|.|::: .::
Mouse   307 QDPTMIGVAVDTVGILGSSVEGKQVLQK--TGTRFERVLMRVGYQAKNASTELKIRCLDAVSSLL 369

  Fly   373 YDFKTPPATEIINIGKNWY--------ECFAGGAHANIIMDLINTPFPDLQMAALSFLKTICKYN 429
            |........:.:.:.::|:        |.|.|         :.|.|||:|..|||.....|....
Mouse   370 YLSPEQQTDDFLGMTESWFSSMSRDSLELFRG---------ISNQPFPELHCAALKVFTAIADQP 425

  Fly   430 WGIVALKNTGGAVEFLLSRQKDLHRDIKYMKWQIMEILSAS---AE-FSPTETIRFTAYVNEGPY 490
            |....:.|:.|.|||::.|..:..:..|..|:::::.|:.|   || |..:..:|..||::||||
Mouse   426 WAQRLMFNSPGFVEFVMDRSVEHDKASKDAKYELVKALANSKTVAEIFGNSNYLRLRAYLSEGPY 490

  Fly   491 HVQADLDVATE 501
            :|:.....|.|
Mouse   491 YVKPVATTAVE 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12096	NP_001285190.1	Proteasom_PSMB	4..502	CDD:287479	138/531 (26%)
Psmd5	NP_542121.2	Proteasom_PSMB	1..504	CDD:287479	138/531 (26%)
		HEAT repeat	88..112	CDD:293787	7/23 (30%)
		HEAT repeat	125..155	CDD:293787	7/32 (22%)
		HEAT repeat	166..191	CDD:293787	9/24 (38%)
		HEAT repeat	202..229	CDD:293787	8/26 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834718
Domainoid	1	1.000	151	1.000	Domainoid score	I4362
eggNOG	1	0.900	-	-		E1_KOG4413
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37999
Inparanoid	1	1.050	151	1.000	Inparanoid score	I4356
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59237
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008750
OrthoInspector	1	1.000	-	-		oto93380
orthoMCL	1	0.900	-	-		OOG6_104314
Panther	1	1.100	-	-	LDO	PTHR13554
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5738
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.790