DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12096 and PSMD5

DIOPT Version :9

Sequence 1:	NP_001285190.1	Gene:	CG12096 / 32269	FlyBaseID:	FBgn0030457	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_005038.1	Gene:	PSMD5 / 5711	HGNCID:	9563	Length:	504	Species:	Homo sapiens

Alignment Length:	534	Identity:	133/534 - (24%)
Similarity:	241/534 - (45%)	Gaps:	96/534 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 KLKALESKPQ--------------RLDAL-TAMNSAIAKEAALPRQIIERLLTTDQLYDCANPAA 60
            :|:||.|..|              ||..| :.:|....::..|...|:||||      ....|.
Human    21 ELRALHSVLQAVPLNELRQQAAELRLGPLFSLLNENHREKTTLCVSILERLL------QAMEPV- 78

  Fly    61 DSHVPKDQAVDVTLELLCHCLDQLAMDTADEQLSSLLRRGLTHSNPALRAQVLASLFKKLLRQLT 125
              ||.::..||                         |:|||.|.:.:::...|:.:.:.:.....
Human    79 --HVARNLRVD-------------------------LQRGLIHPDDSVKILTLSQIGRIVENSDA 116

  Fly   126 VGQVLTLPNNELIFLILDELKQPDTQSTSLAINILSIVLPQRISNADVQA--------KLVQLLK 182
            |.::|.  |.||:..|:..:...:......||..||.:   .::.|.::|        .|..::|
Human   117 VTEILN--NAELLKQIVYCIGGENLSVAKAAIKSLSRI---SLTQAGLEALFESNLLDDLKSVMK 176

  Fly   183 QNEIVRCRAYELAVVLAKKSATLLSDVTF--ILDAALSELDNDDVLLQASVMELLVPLAEQNHGL 245
            .|:|||.|.|||.:.::..|...|:..|.  ::...|.||..:|||::|:.:|::..||..:||.
Human   177 TNDIVRYRVYELIIEISSVSPESLNYCTTSGLVTQLLRELTGEDVLVRATCIEMVTSLAYTHHGR 241

  Fly   246 SYMERRRVLDIISYRVQRVEEHPLDALLVPSIMKFFGKISVY-QPLKIIGGYPHMLACLFMQLQS 309
            .|:.:..|:|.||..:...:..|..:..:|..:||||.::|. .|.:|...||..:..:|..::|
Human   242 QYLAQEGVIDQISNIIVGADSDPFSSFYLPGFVKFFGNLAVMDSPQQICERYPIFVEKVFEMIES 306

  Fly   310 EDESILPTAMDTLANLATTPQGKILLNMHFSGA-MEKSFKKYGSHTKKLSAHIKKRLLNSL-DVI 372
            :|.:::..|:||:..|.:..:||.:|..  :|. .|:...:.|..:|.....:|.|.|::: .::
Human   307 QDPTMIGVAVDTVGILGSNVEGKQVLQK--TGTRFERLLMRIGHQSKNAPVELKIRCLDAISSLL 369

  Fly   373 YDFKTPP---ATEIINIGKNWY--------ECFAGGAHANIIMDLINTPFPDLQMAALSFLKTIC 426
            |   .||   ..:::.:.::|:        |.|.|         :.:.|||:|..|||.....|.
Human   370 Y---LPPEQQTDDLLRMTESWFSSLSRDPLELFRG---------ISSQPFPELHCAALKVFTAIA 422

  Fly   427 KYNWGIVALKNTGGAVEFLLSRQKDLHRDIKYMKWQIMEILSAS---AE-FSPTETIRFTAYVNE 487
            ...|....:.|:.|.||:::.|..:..:..|..|:::::.|:.|   || |.....:|...|::|
Human   423 NQPWAQKLMFNSPGFVEYVVDRSVEHDKASKDAKYELVKALANSKTIAEIFGNPNYLRLRTYLSE 487

  Fly   488 GPYHVQADLDVATE 501
            |||:|:.....|.|
Human   488 GPYYVKPVSTTAVE 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12096	NP_001285190.1	Proteasom_PSMB	4..502	CDD:287479	133/534 (25%)
PSMD5	NP_005038.1	Proteasom_PSMB	1..504	CDD:313688	133/534 (25%)
		HEAT repeat	88..112	CDD:293787	6/23 (26%)
		HEAT repeat	125..155	CDD:293787	7/32 (22%)
		HEAT repeat	166..191	CDD:293787	10/24 (42%)
		HEAT repeat	202..229	CDD:293787	8/26 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144599
Domainoid	1	1.000	141	1.000	Domainoid score	I4741
eggNOG	1	0.900	-	-		E1_KOG4413
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37999
Inparanoid	1	1.050	141	1.000	Inparanoid score	I4495
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59237
OrthoDB	1	1.010	-	-		D240962at33208
OrthoFinder	1	1.000	-	-		FOG0008750
OrthoInspector	1	1.000	-	-		oto89809
orthoMCL	1	0.900	-	-		OOG6_104314
Panther	1	1.100	-	-	LDO	PTHR13554
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5738
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800