Protein Alignment Bap60 and Smarcd1

DIOPT Version :10

• Sequence 1: NP_511143.2
• Gene: Bap60 / 32268
• FlyBaseID: FBgn0025463
• Length: 515
• Species: Drosophila melanogaster
• Sequence 2: NP_114030.2
• Gene: Smarcd1 / 83797
• MGIID: 1933623
• Length: 515
• Species: Mus musculus
• Alignment Length: 539
• Identity: 342/539 - (63%)
• Similarity: 385/539 - (71%)
• Gaps: 72/539 - (13%)

  Fly     6 APGQAPVQSRYQP-----PP----PAPGMRPY--PPPGASFPPRGFPLHPNTTQPVPGTANVAGV 59
            |.|.|.|.:...|     ||    ||||...|  |.|||::|..|  :.|.:.....|.:  .|.
Mouse    18 ASGGAGVAAALGPGGTPGPPVRMGPAPGQGLYRSPMPGAAYPRPG--MLPGSRMTPQGPS--MGP 78

  Fly    60 PGVPGVPGV---------------PGPSLLQRAAQQPGFQSSLRGTGAGGGGVGSGGGSKRSNES 109
            ||..|.|.|               |.|..:|:..||                    ....|::.:
Mouse    79 PGYGGNPSVRPGLAQSGMDQSRKRPAPQQIQQVQQQ--------------------AVQNRNHNA 123

  Fly   110 RSLGGGGSKSDFATAKKKKKLAEKILPQKVRDLVPESQAYMDLLTFERKLDATIMRKRLDIQEAL 174
                            ||||:|:|||||::|:||||||||||||.||||||.|||||||||||||
Mouse   124 ----------------KKKKMADKILPQRIRELVPESQAYMDLLAFERKLDQTIMRKRLDIQEAL 172

  Fly   175 KRPMKQKRKLRIFISNTFYPSKEPTNDGEEGAVASWELRVEGRLLED---GKGDPNTKIKRKFSS 236
            |||:||||||||||||||.|:|....|| ||.|||||||||||||||   .|.|. ||.||||||
Mouse   173 KRPIKQKRKLRIFISNTFNPAKSDAEDG-EGTVASWELRVEGRLLEDAALSKYDA-TKQKRKFSS 235

  Fly   237 FFKSLVIELDKELYGPDNHLVEWHRTHTTQETDGFQVKRPGDRNVRCTILLLLDYQPLQFKLDPR 301
            |||||||||||:||||||||||||||.|||||||||||||||.|||||:||:|||||.|||||||
Mouse   236 FFKSLVIELDKDLYGPDNHLVEWHRTATTQETDGFQVKRPGDVNVRCTVLLMLDYQPPQFKLDPR 300

  Fly   302 LARLLGVHTQTRPVIISALWQYIKTHKLQDAHEREYINCDKYLEQIFSCQRMKFAEIPQRLNPLL 366
            ||||||:|||||||||.|||||||||||||.||||::.|||||:|||..|||||:||||||:.||
Mouse   301 LARLLGIHTQTRPVIIQALWQYIKTHKLQDPHEREFVLCDKYLQQIFESQRMKFSEIPQRLHALL 365

  Fly   367 HPPDPIVINHFIE-SGAENKQTACYDIDVEVDDTLKNQMNSFLMSTASQQEIQGLDTKIHETVDT 430
            .||:||:|||.|. ...:.|:|||||||||||||||.||||||:||||||||..||.|||||::|
Mouse   366 MPPEPIIINHVISVDPNDQKKTACYDIDVEVDDTLKTQMNSFLLSTASQQEIATLDNKIHETIET 430

  Fly   431 INQMKTNREFFLSFAKDPQMFIHRWIISETRDLKLMTDVAGNPEEERRAEFYYQPWTHEAVSRYF 495
            |||:||.|||.||||:|||.||:.|:.|:.||||.||||.||||||||||||:|||..|||.|||
Mouse   431 INQLKTQREFMLSFARDPQGFINDWLQSQCRDLKTMTDVVGNPEEERRAEFYFQPWAQEAVCRYF 495

  Fly   496 FTKVNQKRAELEQALGIRN 514
            ::||.|:|.||||||||||
Mouse   496 YSKVQQRRQELEQALGIRN 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bap60	NP_511143.2	SWIB_BAF60A	295..371	CDD:349493	62/75 (83%)
Smarcd1	NP_114030.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..128		35/149 (23%)
		Interaction with ESR1, NR1H4, NR3C1, PGR and SMARCA4. /evidence=ECO:0000250	43..167		59/163 (36%)
		Interaction with SMARCC1 and SMARCC2. /evidence=ECO:0000250	168..474		240/307 (78%)
		Necessary for GR/NR3C1-mediated remodeling and transcription from chromatin, required for GR/NR3C1 interaction with the BRG1/SMARCA4 complex in vivo. /evidence=ECO:0000250	180..515		262/337 (78%)
		SWIB_BAF60A	294..370	CDD:349493	62/75 (83%)