DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Bap60 and Smarcd2

DIOPT Version :9

Sequence 1:	NP_511143.2	Gene:	Bap60 / 32268	FlyBaseID:	FBgn0025463	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	XP_006534615.2	Gene:	Smarcd2 / 83796	MGIID:	1933621	Length:	551	Species:	Mus musculus

Alignment Length:	561	Identity:	307/561 - (54%)
Similarity:	364/561 - (64%)	Gaps:	105/561 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 GFPLHPNTTQPVPGTANVAGVPGVPGVPGVPGPSLLQRAAQQPGFQSSLRGTGAGGG-GV----- 97
            ||||.|.:    ||...||...|.|..|.  ||.:|...|        |||.|..|| ||
Mouse     8 GFPLPPLS----PGGGAVAAALGAPPPPA--GPGMLPSPA--------LRGPGPSGGMGVPGAAA 58

  Fly    98 ----GSGGGS-----KRSNESR-------SLG-------------------GGGSKSDFATAK-- 125
                |..|.:     :|:.|.|       |||                   |..:.|.|.||.
Mouse    59 FRPMGPAGPAAQYQVRRAGERRREGAVSVSLGPQRPGMSPGSRMPMAGLQVGPPAGSPFGTAAPL 123

  Fly   126 --------------------------------KKKKLAEKILPQKVRDLVPESQAYMDLLTFERK 158
                                            |::|:|:|:|||::|:||||||||||||.||||
Mouse   124 RPGMPPTMMDPFRKRLLVPQAQPPMPAQRRGLKRRKMADKVLPQRIRELVPESQAYMDLLAFERK 188

  Fly   159 LDATIMRKRLDIQEALKRPMKQKRKLRIFISNTFYPSK-EPTNDGEEGA---------VASWELR 213
            ||.||.|||::||||:|:|:.|||||||:|||||.||| :..|.|..|.         |||||||
Mouse   189 LDQTIARKRMEIQEAIKKPLTQKRKLRIYISNTFSPSKADGDNAGTAGTPGGTPAADKVASWELR 253

  Fly   214 VEGRLLEDGKGDPNTKIKRKFSSFFKSLVIELDKELYGPDNHLVEWHRTHTTQETDGFQVKRPGD 278
            |||:||:|     .:|.|||||||||||||||||||||||||||||||..|||||||||||||||
Mouse   254 VEGKLLDD-----PSKQKRKFSSFFKSLVIELDKELYGPDNHLVEWHRMPTTQETDGFQVKRPGD 313

  Fly   279 RNVRCTILLLLDYQPLQFKLDPRLARLLGVHTQTRPVIISALWQYIKTHKLQDAHEREYINCDKY 343
            .||:||:||:||:||.|:|||||||||||||||||..|:.|||.|||.::|||.||||||||::|
Mouse   314 LNVKCTLLLMLDHQPPQYKLDPRLARLLGVHTQTRAAIMQALWLYIKHNQLQDGHEREYINCNRY 378

  Fly   344 LEQIFSCQRMKFAEIPQRLNPLLHPPDPIVINHFIE-SGAENKQTACYDIDVEVDDTLKNQMNSF 407
            ..|||||.|::|:|||.:|..||..||||||||.|. ...:.|:||||||||||||.||.||::|
Mouse   379 FRQIFSCGRLRFSEIPMKLAGLLQHPDPIVINHVISVDPNDQKKTACYDIDVEVDDPLKAQMSNF 443

  Fly   408 LMSTASQQEIQGLDTKIHETVDTINQMKTNREFFLSFAKDPQMFIHRWIISETRDLKLMTDVAGN 472
            |.||.:||||..||.|||||:::|||:||.|:|.|||:.:||.||..|:.|:.||||::|||.||
Mouse   444 LASTTNQQEIASLDVKIHETIESINQLKTQRDFMLSFSTEPQDFIQEWLRSQRRDLKIITDVIGN 508

  Fly   473 PEEERRAEFYYQPWTHEAVSRYFFTKVNQKRAELEQALGIR 513
            |||||||.||:|||..|||.|:.|.||.|:|.||||.||||
Mouse   509 PEEERRAAFYHQPWAQEAVGRHIFAKVQQRRQELEQVLGIR 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bap60	NP_511143.2	SWIB_BAF60A	295..371	CDD:349493	51/75 (68%)
Smarcd2	XP_006534615.2	PABP-1234	<43..161	CDD:130689	22/117 (19%)
		Rsc6	250..445	CDD:227818	144/199 (72%)
		SWIB_BAF60B	327..406	CDD:349494	53/78 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	286	1.000	Domainoid score	I1593
eggNOG	1	0.900	-	-		E1_COG5531
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55104
OrthoDB	1	1.010	-	-		D1027566at2759
OrthoFinder	1	1.000	-	-		FOG0000716
OrthoInspector	1	1.000	-	-		otm42871
orthoMCL	1	0.900	-	-		OOG6_100964
Panther	1	1.100	-	-	O	PTHR13844
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1401
SonicParanoid	1	1.000	-	-		X681
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.820