Protein Alignment Bap60 and SMARCD1

DIOPT Version :10

• Sequence 1: NP_511143.2
• Gene: Bap60 / 32268
• FlyBaseID: FBgn0025463
• Length: 515
• Species: Drosophila melanogaster
• Sequence 2: NP_003067.3
• Gene: SMARCD1 / 6602
• HGNCID: 11106
• Length: 515
• Species: Homo sapiens
• Alignment Length: 533
• Identity: 340/533 - (63%)
• Similarity: 382/533 - (71%)
• Gaps: 73/533 - (13%)

  Fly     7 PGQAPVQSRYQPPP----PAPGMRPY--PPPGASFPPRGFPLHPNTTQPVPGTANVAGVPGVPGV 65
            ||..|      .||    ||||...|  |.|||::|..|  :.|.:.....|.:  .|.||..|.
Human    30 PGGTP------GPPVRMGPAPGQGLYRSPMPGAAYPRPG--MLPGSRMTPQGPS--MGPPGYGGN 84

  Fly    66 PGV---------------PGPSLLQRAAQQPGFQSSLRGTGAGGGGVGSGGGSKRSNESRSLGGG 115
            |.|               |.|..:|:..||                    ....|::.:
Human    85 PSVRPGLAQSGMDQSRKRPAPQQIQQVQQQ--------------------AVQNRNHNA------ 123

  Fly   116 GSKSDFATAKKKKKLAEKILPQKVRDLVPESQAYMDLLTFERKLDATIMRKRLDIQEALKRPMKQ 180
                      ||||:|:|||||::|:||||||||||||.||||||.||||||||||||||||:||
Human   124 ----------KKKKMADKILPQRIRELVPESQAYMDLLAFERKLDQTIMRKRLDIQEALKRPIKQ 178

  Fly   181 KRKLRIFISNTFYPSKEPTNDGEEGAVASWELRVEGRLLED---GKGDPNTKIKRKFSSFFKSLV 242
            ||||||||||||.|:|....|| ||.|||||||||||||||   .|.|. ||.||||||||||||
Human   179 KRKLRIFISNTFNPAKSDAEDG-EGTVASWELRVEGRLLEDSALSKYDA-TKQKRKFSSFFKSLV 241

  Fly   243 IELDKELYGPDNHLVEWHRTHTTQETDGFQVKRPGDRNVRCTILLLLDYQPLQFKLDPRLARLLG 307
            |||||:||||||||||||||.|||||||||||||||.|||||:||:|||||.|||||||||||||
Human   242 IELDKDLYGPDNHLVEWHRTATTQETDGFQVKRPGDVNVRCTVLLMLDYQPPQFKLDPRLARLLG 306

  Fly   308 VHTQTRPVIISALWQYIKTHKLQDAHEREYINCDKYLEQIFSCQRMKFAEIPQRLNPLLHPPDPI 372
            :|||||||||.|||||||||||||.||||::.|||||:|||..|||||:||||||:.||.||:||
Human   307 IHTQTRPVIIQALWQYIKTHKLQDPHEREFVICDKYLQQIFESQRMKFSEIPQRLHALLMPPEPI 371

  Fly   373 VINHFIE-SGAENKQTACYDIDVEVDDTLKNQMNSFLMSTASQQEIQGLDTKIHETVDTINQMKT 436
            :|||.|. ...:.|:|||||||||||||||.||||||:||||||||..||.|||||::||||:||
Human   372 IINHVISVDPNDQKKTACYDIDVEVDDTLKTQMNSFLLSTASQQEIATLDNKIHETIETINQLKT 436

  Fly   437 NREFFLSFAKDPQMFIHRWIISETRDLKLMTDVAGNPEEERRAEFYYQPWTHEAVSRYFFTKVNQ 501
            .|||.||||:|||.||:.|:.|:.||||.||||.||||||||||||:|||..|||.|||::||.|
Human   437 QREFMLSFARDPQGFINDWLQSQCRDLKTMTDVVGNPEEERRAEFYFQPWAQEAVCRYFYSKVQQ 501

  Fly   502 KRAELEQALGIRN 514
            :|.||||||||||
Human   502 RRQELEQALGIRN 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Bap60	NP_511143.2	SWIB_BAF60A	295..371	CDD:349493	62/75 (83%)
SMARCD1	NP_003067.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..103		24/82 (29%)
		Interaction with ESR1, NR1H4, NR3C1, PGR and SMARCA4. /evidence=ECO:0000269|PubMed:12917342	43..167		59/163 (36%)
		Interaction with SMARCC1 and SMARCC2. /evidence=ECO:0000269|PubMed:12917342	168..474		240/307 (78%)
		Necessary for GR/NR3C1-mediated remodeling and transcription from chromatin, required for GR/NR3C1 interaction with the BRG1/SMARCA4 complex in vivo	180..515		262/337 (78%)
		SWIB_BAF60A	294..370	CDD:349493	62/75 (83%)