DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Bap60 and smarcd2

DIOPT Version :9

Sequence 1:	NP_511143.2	Gene:	Bap60 / 32268	FlyBaseID:	FBgn0025463	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	XP_692749.2	Gene:	smarcd2 / 564317	ZFINID:	ZDB-GENE-080215-1	Length:	501	Species:	Danio rerio

Alignment Length:	517	Identity:	302/517 - (58%)
Similarity:	355/517 - (68%)	Gaps:	54/517 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PPAPGMRPYPPPGASFPP----------RGFPLHPNTTQPVPGTANVAGVP----GVPGVPGVPG 70
            |..|||.|..|..:|.|.          ||....||.....|......|:|    |..|.| :||
Zfish    14 PINPGMNPMNPGHSSAPRMPALPLNSPYRGMSSTPNQYHQRPSMPLSRGMPMGGMGSIGSP-LPG 77

  Fly    71 PSLLQRAAQQPGF-QSSLRGT------GAGGGGVGSGGGSKRSNESRSLGGGGSKSDFATAKKKK 128
            ||.......:||. ||::..|      ...||.:|...|.||                      :
Zfish    78 PSYSGAMPMRPGMPQSAMDPTRKRLLQQQPGGLMGPRRGVKR----------------------R 120

  Fly   129 KLAEKILPQKVRDLVPESQAYMDLLTFERKLDATIMRKRLDIQEALKRPMKQKRKLRIFISNTFY 193
            |:|:|:|||::||||||||||||||.||||||.||.|||::||||:|:|:.|||||||:||||:.
Zfish   121 KMADKVLPQRIRDLVPESQAYMDLLAFERKLDQTIARKRMEIQEAIKKPITQKRKLRIYISNTYT 185

  Fly   194 PSKEPTNDGEEG-AVASWELRVEGRLLEDGKGDPNTKIKRKFSSFFKSLVIELDKELYGPDNHLV 257
            |.|.   :|||. .||||||||||:|||    ||. |:|||||||||||||||||||||||||||
Zfish   186 PGKP---EGEEAEKVASWELRVEGKLLE----DPG-KLKRKFSSFFKSLVIELDKELYGPDNHLV 242

  Fly   258 EWHRTHTTQETDGFQVKRPGDRNVRCTILLLLDYQPLQFKLDPRLARLLGVHTQTRPVIISALWQ 322
            ||||..|||||||||||||||.||:||:||:||:||.|:|||||||||||||||||..|:.|||.
Zfish   243 EWHRMPTTQETDGFQVKRPGDVNVKCTLLLMLDHQPPQYKLDPRLARLLGVHTQTRASIMQALWL 307

  Fly   323 YIKTHKLQDAHEREYINCDKYLEQIFSCQRMKFAEIPQRLNPLLHPPDPIVINHFIE-SGAENKQ 386
            |||.:||||.||:|||||::|..|||.|.||:|::||.:|..||..||||||||.|. ...:.|:
Zfish   308 YIKNNKLQDCHEKEYINCNRYFRQIFGCPRMRFSDIPMKLASLLQHPDPIVINHIISVDPNDQKK 372

  Fly   387 TACYDIDVEVDDTLKNQMNSFLMSTASQQEIQGLDTKIHETVDTINQMKTNREFFLSFAKDPQMF 451
            |||:||||||||.||.||..||.||.|||||..|:.|||||:::|||:||.|:|.|||:..||.|
Zfish   373 TACFDIDVEVDDPLKAQMTGFLSSTTSQQEIATLEMKIHETIESINQLKTQRDFMLSFSNSPQEF 437

  Fly   452 IHRWIISETRDLKLMTDVAGNPEEERRAEFYYQPWTHEAVSRYFFTKVNQKRAELEQALGIR 513
            |..|:.|::||||||||..||||||||.|||:.||..|||.||.|:||.|:|.||||.||||
Zfish   438 IQDWLKSQSRDLKLMTDTVGNPEEERRTEFYHSPWVTEAVGRYIFSKVQQRRQELEQVLGIR 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bap60	NP_511143.2	SWIB_BAF60A	295..371	CDD:349493	50/75 (67%)
smarcd2	XP_692749.2	Forkhead_N	1..99	CDD:254796	26/85 (31%)
		Rsc6	200..400	CDD:227818	147/204 (72%)
		SWIB	280..351	CDD:280380	47/70 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	280	1.000	Domainoid score	I1639
eggNOG	1	0.900	-	-		E1_COG5531
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55104
OrthoDB	1	1.010	-	-		D1027566at2759
OrthoFinder	1	1.000	-	-		FOG0000716
OrthoInspector	1	1.000	-	-		otm26106
orthoMCL	1	0.900	-	-		OOG6_100964
Panther	1	1.100	-	-	O	PTHR13844
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1401
SonicParanoid	1	1.000	-	-		X681
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.820