DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bap60 and ham-3

DIOPT Version :9

Sequence 1:	NP_511143.2	Gene:	Bap60 / 32268	FlyBaseID:	FBgn0025463	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_499250.1	Gene:	ham-3 / 176426	WormBaseID:	WBGene00044072	Length:	446	Species:	Caenorhabditis elegans

Alignment Length:	505	Identity:	255/505 - (50%)
Similarity:	324/505 - (64%)	Gaps:	81/505 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RPYPPPGASFPPRGFPLHPNTTQ--------PVPG-TANVAGVPGVPGVPGVPGPSLLQRAAQQP 81
            ||..|.|..|.      ||.|.|        |:|| ||.:.|                .|..|.|
Worm     6 RPPVPQGPRFN------HPATPQQVRRPINAPLPGQTAQIQG----------------NRGPQPP 48

  Fly    82 GFQSSLRGTGAGGGGVGSGGGSKRSNESRSLGGGGSKSDFATAKKKKKLAEKILPQKVRDLVPES 146
                                                       ||||:.|:|::..|||:|||||
Worm    49 -------------------------------------------KKKKRYADKLIQPKVRELVPES 70

  Fly   147 QAYMDLLTFERKLDATIMRKRLDIQEALKRPMKQKRKLRIFISNTFYPSKEPTNDGEEGAVASWE 211
            |||||||.||:|||:||.||::|:|||||||.|.|::|||:||:||...|||..:|::.:|..||
Worm    71 QAYMDLLAFEQKLDSTITRKKIDVQEALKRPQKIKKRLRIYISHTFIAGKEPEKEGDDASVPMWE 135

  Fly   212 LRVEGRLLEDGK-----GDPNTKIKRKFSSFFKSLVIELDKELYGPDNHLVEWHRTHTTQETDGF 271
            ||||||||:|.:     .:|....|||||||||||||||||::|||||||||||||..|.|||||
Worm   136 LRVEGRLLDDMQHPTVGANPRPAPKRKFSSFFKSLVIELDKDIYGPDNHLVEWHRTPQTNETDGF 200

  Fly   272 QVKRPGDRNVRCTILLLLDYQPLQFKLDPRLARLLGVHTQTRPVIISALWQYIKTHKLQDAHERE 336
            ||||||||.|:|||||||||||::|||.||||::||:..:|||.||.|||||||||||||..:|:
Worm   201 QVKRPGDRPVKCTILLLLDYQPMKFKLHPRLAKVLGIAAETRPRIIEALWQYIKTHKLQDPQDRD 265

  Fly   337 YINCDKYLEQIFSCQRMKFAEIPQRLNPLLHPPDPIVINHFIE--SGAENKQTACYDIDVEVDDT 399
            .||.|.:|||.|...:|:|.||||||:.||..|||:|:||.|:  ...::|.:||||||||::|.
Worm   266 TINNDLFLEQCFGVSKMRFMEIPQRLHQLLQQPDPLVLNHIIQRPDDGQDKTSACYDIDVELEDP 330

  Fly   400 LKNQMNSFLMSTASQQEIQGLDTKIHETVDTINQMKTNREFFLSFAKDPQMFIHRWIISETRDLK 464
            :|.||.:|:.:..:..:||.||.||.:.||.||:||..|:|||.|:.:|..||.:|::|:..|||
Worm   331 VKQQMANFVHNQTNANDIQLLDQKIFDLVDQINEMKLRRDFFLRFSNEPSGFIKKWVVSQNSDLK 395

  Fly   465 LMTDVAGNPEEERRAEFYYQPWTHEAVSRYFFTKVNQKRAELEQALGIRN 514
            .:|:.:|:.|.:|.|..|....|.|.||||.:.|:.||||||||:|||||
Worm   396 TLTESSGDGESDRYATTYSTTDTDEGVSRYMYQKIQQKRAELEQSLGIRN 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bap60	NP_511143.2	SWIB_BAF60A	295..371	CDD:349493	46/75 (61%)
ham-3	NP_499250.1	SWIB-MDM2	224..300	CDD:422951	46/75 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161111
Domainoid	1	1.000	248	1.000	Domainoid score	I1171
eggNOG	1	0.900	-	-		E1_COG5531
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20670
Inparanoid	1	1.050	484	1.000	Inparanoid score	I795
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55104
OrthoDB	1	1.010	-	-		D1027566at2759
OrthoFinder	1	1.000	-	-		FOG0000716
OrthoInspector	1	1.000	-	-		otm14111
orthoMCL	1	0.900	-	-		OOG6_100964
Panther	1	1.100	-	-	LDO	PTHR13844
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1401
SonicParanoid	1	1.000	-	-		X681
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800