DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4332 and clptm1l

DIOPT Version :9

Sequence 1:	NP_572861.1	Gene:	CG4332 / 32267	FlyBaseID:	FBgn0030456	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001002380.1	Gene:	clptm1l / 436653	ZFINID:	ZDB-GENE-040718-75	Length:	538	Species:	Danio rerio

Alignment Length:	555	Identity:	251/555 - (45%)
Similarity:	358/555 - (64%)	Gaps:	44/555 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SISTLLGVAFLAYIGHSIYQMSQLFTTLQCS---GVPCYTSFLADRPRLQLALFSSLSRSPIATE 66
            |.::|:...||.|:.|:.:.|..:..|..|.   ...|.:.:||.:|||||:::::|  .|.|..
Zfish     6 SFTSLIVGVFLLYVLHTCWVMYGIVYTKPCEKRRAESCISPYLAAKPRLQLSVYTAL--RPNADG 68

  Fly    67 VRDL-YKAKRFDYDQNFEHDFEVDVPLRTRRNGSLYLHVVLALEG-EPLEWRSLRRDGPTVVHTM 129
            ...| ::.:.||.:..||....|.:|.:||:||:||..|.|...| .|  |:.     |..||.:
Zfish    69 GHSLIHREEEFDVNTKFEKLVNVSLPKKTRKNGTLYAMVFLHQAGVSP--WQD-----PHQVHLV 126

  Fly   130 S-LTDYIVPRAEAFKLL-GDSEKGAAAAVQEKEKKKASTTG---RPSTHIRSNVYVTLLNDLYSV 189
            : ||.|::|:.....|: |..|.      ::.:::|.|:..   ||.:|.||.:.:.::::.:..
Zfish   127 TQLTTYMLPKPPEISLITGQDEP------EKPDQQKQSSDSELDRPVSHWRSRLTLNVVSENFLF 185

  Fly   190 SQADVPPEMAPLIRV---NRNQQILPILQTDTFNTRLKDLVPVTRNTTEFTFSFHYKPVGVGKLR 251
            .:..:|.::...:||   .:....||:|..|..:.|:|||:.:..::||...:..|..:.:||||
Zfish   186 DREALPGDVHRYMRVYQSGKKMIYLPLLFVDELSNRVKDLMEINSSSTELPLTITYDSIALGKLR 250

  Fly   252 LMLLMEHATQALLTIGFATKDIDEVKGIFSDTNVYLLCGTIFVSSIHMLFDFLSFKNDVAFWRKK 316
            ..:.|:.|..:|...||..||.||:||||.|||:|.|..|.||::.|:|||||:||||::||:.|
Zfish   251 FWIHMQDAVYSLQQFGFTEKDADEIKGIFVDTNLYFLALTFFVAAFHLLFDFLAFKNDISFWKHK 315

  Fly   317 QSYEGLSSRTTMWRAFSQIVIFFYLLDENTSYLVLVPVGLGTLIELWKCKKIFRLELSFSGLVRR 381
            :|..|:||:..:||.||.||||.|||||.||.|||||.|:|:|||:||.||.|::.:.:.||...
Zfish   316 KSMVGMSSKAVLWRCFSTIVIFLYLLDEQTSLLVLVPAGIGSLIEVWKVKKAFKIHVIWRGLTPT 380

  Fly   382 KLEQVDRRNGDQAGVKSGQLAE-EQKTDQFDRQGMRYLSYLLYPLCICGAVYSLLYQPHRSWYSW 445
            .|              .|:|.| |::|:::|...|:||||||||||:.||||:|::..::|||||
Zfish   381 FL--------------FGKLDESEKRTEEYDTLAMKYLSYLLYPLCVGGAVYALVFVKYKSWYSW 431

  Fly   446 TLNSLVNGVYAFGFLFMLPQLFVNYKLKSVAALPWRAFMYKAFNTFIDDFFAFIITMPTAHRVAC 510
            .:|||||||||||||||||||||||||||||.|||:|||||||||||||.|||||||||:||:||
Zfish   432 IINSLVNGVYAFGFLFMLPQLFVNYKLKSVAHLPWKAFMYKAFNTFIDDVFAFIITMPTSHRLAC 496

  Fly   511 LRDDIVFIIYLYQRWLYPVDKSRL-DTGLSISETP 544
            .|||:||::|||||||||||:||: :.|:|..|.|
Zfish   497 FRDDVVFLVYLYQRWLYPVDRSRVNEYGVSYDEKP 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4332	NP_572861.1	CLPTM1	10..435	CDD:283294	163/438 (37%)
clptm1l	NP_001002380.1	CLPTM1	11..421	CDD:283294	163/438 (37%)
clptm1l	NP_001002380.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	140..166		5/31 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596450
Domainoid	1	1.000	277	1.000	Domainoid score	I1700
eggNOG	1	0.900	-	-		E1_KOG2489
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12767
Inparanoid	1	1.050	460	1.000	Inparanoid score	I1536
OMA	1	1.010	-	-		QHG47987
OrthoDB	1	1.010	-	-		D1106937at2759
OrthoFinder	1	1.000	-	-		FOG0007284
OrthoInspector	1	1.000	-	-		oto40302
orthoMCL	1	0.900	-	-		OOG6_100901
Panther	1	1.100	-	-	LDO	PTHR21347
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4165
SonicParanoid	1	1.000	-	-		X5387
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800