DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4332 and T13H5.8

DIOPT Version :9

Sequence 1:	NP_572861.1	Gene:	CG4332 / 32267	FlyBaseID:	FBgn0030456	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_495797.1	Gene:	T13H5.8 / 174362	WormBaseID:	WBGene00011761	Length:	566	Species:	Caenorhabditis elegans

Alignment Length:	553	Identity:	228/553 - (41%)
Similarity:	331/553 - (59%)	Gaps:	56/553 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SISTLLGVAFLAYIGHSIYQMSQLFT----TLQCSGVPCYTSFLADRPR-------LQLALFSSL 58
            :::.::...||:::.::.:|:.:|||    |.|.|...||:..:  :|.       |||.::.|.
Worm     4 NLTKIVSTLFLSFMFYNFFQLYKLFTPELCTDQDSDELCYSPIV--QPNHEGLYDLLQLRVYFST 66

  Fly    59 SRSPIATEVRDLYKAKRFDYDQNFEHDFEVDVPLRTRRNGSLYLHVVL---ALEG-EPLE--WRS 117
            .|..:.|.:..:...:..|   .|:.|.:|.:|....::|.||.|.:|   ..:| .|::  |:
Worm    67 KRDALETLITTVENLQVAD---AFQKDLQVKIPSSVAKDGYLYAHTILLPHKFDGRNPMQASWK- 127

  Fly   118 LRRDGPTVVHTMS-LTDYIVPRAEAFKLLGDSEKGAAAAVQEKEKKKASTTGRPSTHIRSNVYVT 181
                    ||..: :..:..|.|:.|:||||.|  ....|.||.||..|.....:.|.|:.:.|.
Worm   128 --------VHVAAPMVVFQEPVAKTFQLLGDEE--VKEKVDEKPKKSKSKVVELAAHFRTILPVR 182

  Fly   182 LLNDLYSVSQADVPPEMAPLIRVNRNQQ---ILPILQTDTFNTRLKDLVPVTRNTTEFTFSFHYK 243
            ::::.....:..|..|:|..:.:.|..:   .|||:..|..:.|.|.|..:.........:.:|:
Worm   183 IVSEPNRYVKTKVSGELADFLTIQRQDKKEGYLPIMFVDEMSMRSKHLYELADFQKSVNLTINYE 247

  Fly   244 PVGVGKLRLMLLMEHATQALLTIGFATKDIDEVKGIFSDTNVYLLCGTIFVSSIHMLFDFLSFKN 308
            |..|.||.|:.....:|..|:..||..||:||::|:|::|::.||..|.|||::|:|||.|:|||
Worm   248 PTSVAKLLLLTSTARSTHQLMKHGFKDKDVDELRGLFTETSIVLLMVTFFVSTLHLLFDALAFKN 312

  Fly   309 DVAFWRKKQSYEGLSSRTTMWRAFSQIVIFFYLLDENTSYLVLVPVGLGTLIELWKCKKIFRLEL 373
            |::||:.::|..|||::|.:||.|||.:|||||.|:.||.|||:|.|:.|:||.||....:::.:
Worm   313 DISFWKGRKSMVGLSTKTLLWRCFSQTIIFFYLFDQQTSLLVLIPAGIATVIEYWKVTIAYKVTI 377

  Fly   374 SFSGLVRRKLEQVDRRNGDQAGVKSGQ-LAEEQKTDQFDRQGMRYLSYLLYPLCICGAVYSLLYQ 437
            ::.                  |:|.|: ..||.:||..|.|.|:|||.||.||.|.||:|||||.
Worm   378 TWK------------------GIKFGKHSTEEDETDSIDSQAMKYLSILLVPLVIGGAIYSLLYV 424

  Fly   438 PHRSWYSWTLNSLVNGVYAFGFLFMLPQLFVNYKLKSVAALPWRAFMYKAFNTFIDDFFAFIITM 502
            ||:||.||.|.:..|||||||||||||||||||||||||.|||||||||||||||||.|||:|||
Worm   425 PHKSWRSWILETSANGVYAFGFLFMLPQLFVNYKLKSVAHLPWRAFMYKAFNTFIDDLFAFVITM 489

  Fly   503 PTAHRVACLRDDIVFIIYLYQRWLYPVDKSRLD 535
            |||||:||.||||||::|||||||||||.:|::
Worm   490 PTAHRMACFRDDIVFLVYLYQRWLYPVDYTRIN 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4332	NP_572861.1	CLPTM1	10..435	CDD:283294	145/446 (33%)
T13H5.8	NP_495797.1	CLPTM1	9..422	CDD:283294	145/446 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167631
Domainoid	1	1.000	233	1.000	Domainoid score	I1356
eggNOG	1	0.900	-	-		E1_KOG2489
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12767
Inparanoid	1	1.050	409	1.000	Inparanoid score	I1056
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47987
OrthoDB	1	1.010	-	-		D1106937at2759
OrthoFinder	1	1.000	-	-		FOG0007284
OrthoInspector	1	1.000	-	-		oto19082
orthoMCL	1	0.900	-	-		OOG6_100901
Panther	1	1.100	-	-	LDO	PTHR21347
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4165
SonicParanoid	1	1.000	-	-		X5387
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.840