DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4332 and CLPTM1

DIOPT Version :9

Sequence 1:	NP_572861.1	Gene:	CG4332 / 32267	FlyBaseID:	FBgn0030456	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001285.1	Gene:	CLPTM1 / 1209	HGNCID:	2087	Length:	669	Species:	Homo sapiens

Alignment Length:	501	Identity:	178/501 - (35%)
Similarity:	266/501 - (53%)	Gaps:	55/501 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 DQNFEHDFEVDVPLRTRRNGSLYLHVVLALEG---EPLEWRSLRRDGPTVVHTMSLTDYIVPRAE 140
            |..:||..|:|:|...::|||:|:||.....|   :|.: ::|.|...||..:..:..|...|.:
Human   143 DGCYEHFAELDIPQSVQQNGSIYIHVYFTKSGFHPDPRQ-KALYRRLATVHMSRMINKYKRRRFQ 206

  Fly   141 AFK--LLGDSEKGAAAAVQEKEKKKASTTG--RPSTHIRSNVYVTLLNDLYSVSQADVPPEMAPL 201
            ..|  |.|::|      ...:..|:|...|  ...:|...|:.:.:::|.....:..|||.:...
Human   207 KTKNLLTGETE------ADPEMIKRAEDYGPVEVISHWHPNITINIVDDHTPWVKGSVPPPLDQY 265

  Fly   202 IRVNR-NQQILPILQTDTFNTRLKDLVPVTRNTTEFTFSFHYKPVGVGKLRLMLLMEHATQALLT 265
            ::.:. :....||:..:.:....||..|:..:.........:.|:.:.:.:|     :|.|:..:
Human   266 VKFDAVSGDYYPIIYFNDYWNLQKDYYPINESLASLPLRVSFCPLSLWRWQL-----YAAQSTKS 325

  Fly   266 ----IG-----FATKDIDEVKGIFSDTNVYLLCGTIFVSSIHMLFDFLSFKNDVAFWRKKQSYEG 321
                :|     .:.::.|.||....:||.|||..||.||.:|.:|:||:||||:.||..:||.||
Human   326 PWNFLGDELYEQSDEEQDSVKVALLETNPYLLALTIIVSIVHSVFEFLAFKNDIQFWNSRQSLEG 390

  Fly   322 LSSRTTMWRAFSQIVIFFYLLDENTSYLVLVPVGLGTLIELWKCKKIFRLELSFSGLVRRKLEQV 386
            ||.|:..:..|...|:..|:||..|:::|.|.|.:|.||:|||..|:..:.|.
Human   391 LSVRSVFFGVFQSFVVLLYILDNETNFVVQVSVFIGVLIDLWKITKVMDVRLD------------ 443

  Fly   387 DRRNGDQAGV------KSGQLAEEQKTDQFDRQGMRYLSYLLYPLCICGAVYSLLYQPHRSWYSW 445
              |....||:      |......|..|..:|....||||::|:||..|.|||||||..|:.||||
Human   444 --REHRVAGIFPRLSFKDKSTYIESSTKVYDDMAFRYLSWILFPLLGCYAVYSLLYLEHKGWYSW 506

  Fly   446 TLNSLVNGVYAFGFLFMLPQLFVNYKLKSVAALPWRAFMYKAFNTFIDDFFAFIITMPTAHRVAC 510
            .|:.|...:..|||:.|.||||:||||||||.||||...|||.||||||.|||:|.||..:|:.|
Human   507 VLSMLYGFLLTFGFITMTPQLFINYKLKSVAHLPWRMLTYKALNTFIDDLFAFVIKMPVMYRIGC 571

  Fly   511 LRDDIVFIIYLYQRWLYPVDKSRL-DTGLSISETPDTGNSSSASIA 555
            ||||:||.|||||||:|.||.:|: :.|:| .|.|    :::|.:|
Human   572 LRDDVVFFIYLYQRWIYRVDPTRVNEFGMS-GEDP----TAAAPVA 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4332	NP_572861.1	CLPTM1	10..435	CDD:283294	108/378 (29%)
CLPTM1	NP_001285.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50
		CLPTM1	57..497	CDD:398952	109/379 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	614..669
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1106937at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100901
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.720