DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32645 and CG10183

DIOPT Version :9

Sequence 1:	NP_727670.1	Gene:	CG32645 / 32264	FlyBaseID:	FBgn0052645	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_651160.3	Gene:	CG10183 / 42782	FlyBaseID:	FBgn0039093	Length:	685	Species:	Drosophila melanogaster

Alignment Length:	776	Identity:	162/776 - (20%)
Similarity:	277/776 - (35%)	Gaps:	232/776 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 CSRDMRSYLGGLSDAKMWAVKMDDASGHYTSGFFYGNNYWMGSLALCDAIDDGQIVAPGKDNSSS 170
            |..||:....||.....||:||.|:.|.:.||..||..|.:|:...|..|:        ::.|||
  Fly    60 CLVDMKELFAGLKTGSYWALKMLDSWGSFPSGLLYGTFYDLGNFDECLNIN--------QEISSS 116

  Fly   171 AASSPESETKNSGLPFAAAHTQGYSSVYNAPPPFVPGFY-VIKMQLNETLPTQVLRI----IYVG 230
            ..                                :.|.| .:.:.|.:.|.|.:..:    |.:.
  Fly   117 QT--------------------------------IKGKYCFMAVPLRDVLDTGIESLEGMQIKIA 149

  Fly   231 MCLPSSCSIADIGQMSSRAHVELPSRDLRVLDIRVPTDKEFNIWADKTFC-------------LL 282
            .|.|:|||...|...:.:.:..           :|.:...|||..|:..|             ..
  Fly   150 TCFPASCSATQIETFAGQLYQN-----------KVNSSMSFNISIDEDGCQTSDPVPWDGLTIFT 203

  Fly   283 IVVSSIVLGLICCGTLFEIYLRRKLKEALRRQDKEMMNNSETSSGIGCASSDYSDTMTAHDDP-- 345
            :|:.|::..::...||::.:|                          |         |....|
  Fly   204 VVILSVLTLIVVSSTLYDYFL--------------------------C---------TTQQTPAL 233

  Fly   346 LKQSDHSQSSNSLKQLDALVLNLPPNDNDSGNGHHHDHDAEHDHHDHHRSGSNNSNSDEHLEGHL 410
            :|......:|.:|.:|:.                                |::|||
  Fly   234 IKIISARANSRALFRLEV--------------------------------GNSNSN--------- 257

  Fly   411 HEPEKLSIYSELLLSFSAITNFNAICDRNVGADTIPCIHGLRAFSMAWVILGHTCI-------VV 468
                                             .|.|:||:|..|:.||:..|..:       :.
  Fly   258 ---------------------------------VIDCLHGIRCMSLIWVVFLHEHMYSLISPNIN 289

  Fly   469 FKYSDNMEMRKEVEQNFFFQAITNGPFSVDTFFFISGFLISYIYFRTNAK--GKLNKLSKGANEF 531
            |.|:  :...::...:||.    :|.||||||.||.|.|:|....||..|  ||||
  Fly   290 FTYA--LAWLEKPTSSFFI----HGYFSVDTFLFIGGLLVSLTALRTMEKTNGKLN--------- 339

  Fly   532 TAGTAHFFGLVAYRFMRLTAPYLFVLGVVQVTMKYLATYSIFDPPTMDHITCPDYWWRNILYINT 596
                  ...:..:|.:|:.......:.:....|..::...:|.........|.:.|:.::|:|..
  Fly   340 ------IPRMYVHRIIRILPVLAMAILIYVKLMPVVSGGPLFKSGFHGKEECVNGWYWDLLFIQN 398

  Fly   597 LFPVDEMCMLWSWYLANDTQFYMIGAIILIVGVRHFKLSAITTLVFLVL-----SWITTAVIAFT 656
            .  ..:.|:..|||||.|.|.|::..::|. |:..:...|...:|.:|:     .:.|..|..::
  Fly   399 Y--ATKTCLDQSWYLAVDMQLYILSPLLLF-GLYKWGKKAAWAIVGIVVLLSGCLFATQMVNHYS 460

  Fly   657 NNHRPNTDDPLALFDKIYDKPWTRLGPYLIGMAVGWIL-FRTNCKIRLPKLTVATAWTLAMLNLF 720
            .:.:....|..| ..|:|....|...|:|||...|:.| .....|.:|..|.:.:.|.:::..:|
  Fly   461 MSIKNGGGDDEA-NSKLYLATHTHATPWLIGFLFGYFLHMNRGRKFQLSWLVLWSGWFISLAMIF 524

  Fly   721 VLVFGLYKA------DLSQFTAAAYSSLSHSAWALSLAWITIACSTGYGGYINSLLSAPCLYPFS 779
            ..:|..|.:      .||....:.|.:|:...|.|::.|:...|..||.|..||.||.|...|.|
  Fly   525 TSIFATYPSAKWSAPPLSTLDESLYYTLTRVGWPLAMCWVVFVCIQGYCGLANSFLSTPLWQPLS 589

  Fly   780 RVTYCAYLVHPIVIRSMALNSDAPLHLGGDLMVVMF---FGLTVASYFLSFVVSMSFEAPV 837
            |::|..::.|..|....:.|.....:.....:::.|   ||:   |..:|:|:.:..|||:
  Fly   590 RLSYSVFIWHMFVQEINSRNVRTSTYFSSYTVMLNFWSDFGI---SLIMSYVLYLIIEAPI 647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32645	NP_727670.1	NRF	121..272	CDD:214781	30/155 (19%)
		Acyl_transf_3	445..831	CDD:280013	103/409 (25%)
		OafA	450..853	CDD:224748	103/412 (25%)
CG10183	NP_651160.3	NRF	75..190	CDD:214781	35/165 (21%)
		OafA	245..647	CDD:224748	111/503 (22%)
		Acyl_transf_3	259..641	CDD:280013	103/409 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	204	1.000	Domainoid score	I1719
eggNOG	1	0.900	-	-		E1_KOG3700
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100705
Panther	1	1.100	-	-	P	PTHR11161
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X299
	7	6.820