DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32645 and nrf-6

DIOPT Version :9

Sequence 1:	NP_727670.1	Gene:	CG32645 / 32264	FlyBaseID:	FBgn0052645	Length:	853	Species:	Drosophila melanogaster
Sequence 2:	NP_495680.1	Gene:	nrf-6 / 174287	WormBaseID:	WBGene00003813	Length:	822	Species:	Caenorhabditis elegans

Alignment Length:	947	Identity:	215/947 - (22%)
Similarity:	394/947 - (41%)	Gaps:	249/947 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 MRRTLVLAML--LSLLATPQAAIDKDDGKFPPGRHNLSSAPDQHNVINLSLHGDLTAATLLPHVD 64
            |||.|:.|:|  |::::..:::...|...|       ||....::..:....|.: .:..:...|
Worm     4 MRRLLIFAVLVILTVISNSKSSYKYDGSLF-------SSKELDYDETDTKAMGSV-FSRYMSDSD 60

  Fly    65 PKLSYDLSQTRRL-------RDALNVFDLAVLAAQWGQVE--SSGGVSANCSRDMR--SYLG--- 115
            .:|..||...|..       ||.....:|.::......||  .|..:|..|..||.  ::.|
Worm    61 AQLILDLDFFRHFFNYAEAYRDGAEEGNLELMKYAVEMVEKLKSFDISMACVGDMMHLAWTGVEY 125

  Fly   116 --------GLSDAKM------------WAVKMDDASGHYTSGFFYGNNYWMGSLALCDAIDDGQI 160
                    ..||.|.            |...:.||.|...:|...|||.|:||.:.|..||..:.
Worm   126 ATHVEEHKNCSDCKCTPLFQQKKSERHWIFNVFDAMGKVPAGIMSGNNLWVGSWSTCRKIDVVKN 190

  Fly   161 VAPGKDNSSSAASSPESETKNSGLPFAAAHTQGYSSVYNAPPPFVPGFYVIKMQLNETLPTQVLR 225
            ....|.......::.::..:::.|.:       :.::.:.||........:|...::.....:..
Worm   191 AQGQKWKGQYCLATIDAYERDNPLVY-------FGNMMSGPPDKHCYDKTVKNVTDDGFCFALFP 248

  Fly   226 IIYVGMCLPSSCSIADIGQMSSRAHVELPSRDLRVLDIRVPTDKEFNI--------WAD------ 276
            ::..|:|:|::|:..|:.||.|.|        :|..:..|.|....|:        ::|
Worm   249 VLKFGVCMPNTCTNHDVKQMLSFA--------IRATEGAVGTKSVCNVDVECRAESYSDAMSENG 305

  Fly   277 -KTFCLLIVVSSIVLGLICCGTLFEIYLRRKLKEALRRQDKEMMNNSETSSGIGCASSDYSDTMT 340
             ..|.|.::::::|  |:..|||::::
Worm   306 LAMFALYLLIATVV--LVTFGTLYDLF-------------------------------------- 330

  Fly   341 AHDDPLKQSDHSQSSNSLKQLDALVLNLPPNDNDSGNGHHHDHDAEHDHHDHHRSGSNNSNSDEH 405
                                    :::..|.|..:.:..:|.
Worm   331 ------------------------IVSKAPQDEKNSSAFNHP----------------------- 348

  Fly   406 LEGHLHEPEKLSIYSELLLSFSAITNFNAICDRNVGADTIPCIHGLRAFSMAWVILGHTCIVVFK 470
                         :.:.:|:||..||.:.|.........|..:||:|..||.|:|||||    :.
Worm   349 -------------FIKFILAFSMYTNGSEILQSKKNDREINSLHGVRFLSMCWIILGHT----YY 396

  Fly   471 Y------SDNM-EMRKEVEQNFFFQAITNGPFSVDTFFFISGFLISYIYFRTNAKGKLN---KLS 525
            |      :||: .......:.|..|.|...|.:||:|||:||.|.::.:|:...|...|   |||
Worm   397 YIGTSLTTDNLVPTLINFPKQFHTQIIVQAPLAVDSFFFLSGMLAAFSFFKKTMKADPNHPPKLS 461

  Fly   526 KGANEFTAGTAHFFGLVAYRFMRLTAPYLFVLGVVQVTM-KYLATYSIFDPPTMDHITCPDYWWR 589
              |..:.....:::    .|::|:|..|:.|: :..||: .|::....:.|  ::...|...||.
Worm   462 --AFNWQTWPMYYY----KRYIRITPTYIIVM-LFDVTLFTYISNGPFWRP--IERQGCSIAWWT 517

  Fly   590 NILYINTLFPVD-EMCMLWSWYLANDTQFYMIGAIILIV-----GVR-----HFKLSAITTLVFL 643
            |::|:|.....| |.||.|:||||||.||::....:|::     |::     ...|.|:::|:.|
Worm   518 NLIYLNNFLLQDQECCMGWTWYLANDMQFHIFLMPLLVIVFLKWGMKVGLGLSTGLIALSSLIRL 582

  Fly   644 VLSW--------ITTA---VIAFTNNHRPNTDDPLALFDKIYDKPWTRLGPYLIGMAVGWIL--- 694
            :::.        |.||   ::...|::          ::.:|.:|:.|..|:::|:.|.::|
Worm   583 IITQIYGYPPAPILTAKLQIVYQLNDY----------WNDVYVRPYIRCTPFIVGIVVAYLLNAW 637

  Fly   695 ---FRTNCKIRLPKLTVATAW-TLAMLNLFVLVFGLY----KADLSQFTAAAYSSLSHSAWALSL 751
               .:.:.||:|.:.||...| |..:|.|: .|||||    ..|:|:.....|:.....|:||:|
Worm   638 TTREQKDLKIKLERRTVIICWCTSTVLGLY-SVFGLYWFAKTGDISKPWEILYTIFGTPAYALAL 701

  Fly   752 AWITIACSTGYGGYINSLLSAPCLYPFSRVTYCAYLVHPIVIRSMALNSDAPLHLGGDLMVVMFF 816
            .|:..||:||.||.::::||.....|.|::|:||||:|||:::...|:...|.|....:.::.:
Worm   702 GWVVFACTTGNGGPVDTILSWRLFVPLSKITFCAYLLHPIMLQIYNLSRPQPFHFTTFIQMIRY- 765

  Fly   817 GLTV----ASYFLSFVVSMSFEAPVVTMLKILSPSRK 849
              ||    |||.::|..|::||.|:..:.::|..|:|
Worm   766 --TVEAVFASYTIAFFFSLAFEKPLNKIDEMLFNSKK 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32645	NP_727670.1	NRF	121..272	CDD:214781	32/162 (20%)
		Acyl_transf_3	445..831	CDD:280013	128/433 (30%)
		OafA	450..853	CDD:224748	133/448 (30%)
nrf-6	NP_495680.1	NRF	151..288	CDD:214781	31/151 (21%)
		OafA	375..790	CDD:224748	132/441 (30%)
		Acyl_transf_3	375..777	CDD:280013	127/428 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3700
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	243	1.000	Inparanoid score	I2076
Isobase	1	0.950	-	0	Normalized mean entropy	S7984
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1171418at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100705
Panther	1	1.100	-	-	O	PTHR11161
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4398
SonicParanoid	1	1.000	-	-		X299
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.850