DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MFS10 and DAL5

DIOPT Version :9

Sequence 1:	NP_001285188.1	Gene:	MFS10 / 32263	FlyBaseID:	FBgn0030452	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_012686.3	Gene:	DAL5 / 853617	SGDID:	S000003913	Length:	543	Species:	Saccharomyces cerevisiae

Alignment Length:	577	Identity:	115/577 - (19%)
Similarity:	198/577 - (34%)	Gaps:	157/577 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 DPSTSSNSS-----------ASAERSDDEADDEREAFCSGERPLIRSSGAAEENHGCGPKTRHI- 70
            |.||:||:|           |..:..|..|:.......|....::..|...:|......:.:.|
Yeast     4 DASTNSNASLDEKNLNITSEAEIKNEDVTAEPVLSTVLSPNGKIVYISDKVDEAMKLAEEAKEIE 68

  Fly    71 -----------------FGFMGFLGFAVVYAMRVNLSVAIVAMVNQTAIPHSNSSVIDTDTCPLP 118
                             |..|..| :||.:..:::.|.|.|..:......|.:
Yeast    69 VTPEEDRKLRWKIDYCMFPLMCIL-YAVQFMDKISTSSAAVMGLRTDLKMHGD------------ 120

  Fly   119 APHHNGSDPNPQKEGEFVWDEATQGLVLGSFFYGYVLTQVPGGRMAELYGGKKIYGYGVLITAVF 183
                           ::.|       |..:|::||:...:  |.:..::   :...:...:.|||
Yeast   121 ---------------QYSW-------VTSAFYFGYLFMNL--GPVQFIF---QRTSHMSKMLAVF 158

  Fly   184 TLI--TPLAAH----WDLPLLVLVRILEGMGEGVTYPAMHAMLAHWIPPLERNKFAAIVYAGSNI 242
            .:|  ..||.|    ...|..:::|:|.|..|.|..|....:.|.:....|:....:|.:..:.:
Yeast   159 IVIWGMLLALHAAPTVKYPSFIVLRVLLGCAESVVTPCFTIITAQYWKTEEQFTRVSIWFGMNGL 223

  Fly   243 GTVISMPLA-GWLCSLD--FLGGWPSAFYIFGL----LGILWFIAWMYLVYDKPSDHPRISESER 300
            |:::...:| |.....|  .:.||.:.|.|.|:    :|||.|: |   :.|.||....:|:.|:
Yeast   224 GSILINAIAYGVYIHQDSYAIKGWRTLFVITGVITIFIGILIFL-W---IPDDPSKARFLSKREK 284

  Fly   301 EYIERSLQVQRLINQDLAEAEEEEGQDEVSLRAPPEEPIPWSSLLTSVPLWAILLTQCGQGWAFY 365
            ..:     |||:.:.     ::..|..|:......|       .|..|..|...|         :
Yeast   285 LMV-----VQRIRSN-----QQGFGNHEIKKYQIIE-------ALKDVRTWLYFL---------F 323

  Fly   366 TQLTELP-----TYMSNILHFDI---QSNALLNAVP----------------------------Y 394
            |..:.:|     ::||.:|:.|.   ....||..:|                            |
Yeast   324 TVSSNIPNGGISSFMSILLNSDFGYSSKETLLMGLPTGAVELVGCPLFGILAVYAANKKIPFWKY 388

  Fly   395 LTSWFVGIACSAL-ADWMLA----RRYISLLNSYKLWNTVASVVPSLGLIGIIYVGCDWVWVTFM 454
            ..||.:..|..|| |..||.    .:...|..:|..:.:..|.:..|..|.....|....| |..
Yeast   389 KLSWAIFAAVLALIASCMLGFATNSKKARLAGAYLWYISPVSFICVLSNISANSSGYSKKW-TVS 452

  Fly   455 LAGVGSFGGAVYAGNQMNHIALSPRYAGTMYGITNSAANICGFLAPYVIGLIINHRE 511
            ...:.::..|..||.|......:|:|.|....:....|.:...|:   |.||:|.||
Yeast   453 SINLVAYAAANLAGPQTFIAKQAPKYHGAKVAMVVCYAVMIVLLS---ILLIVNLRE 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS10	NP_001285188.1	2A0114euk	63..547	CDD:129972	103/521 (20%)
MFS10	NP_001285188.1	MFS	134..538	CDD:119392	93/432 (22%)
DAL5	NP_012686.3	MFS_FEN2_like	80..496	CDD:340885	95/486 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I2891
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	52	1.000	Inparanoid score	I1824
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X142
TreeFam	0	0.000	Not matched by this tool.
	4	4.050