DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS10 and Slc17a6

DIOPT Version :9

Sequence 1:	NP_001285188.1	Gene:	MFS10 / 32263	FlyBaseID:	FBgn0030452	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_445879.1	Gene:	Slc17a6 / 84487	RGDID:	620531	Length:	582	Species:	Rattus norvegicus

Alignment Length:	492	Identity:	158/492 - (32%)
Similarity:	258/492 - (52%)	Gaps:	42/492 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 GPKTRHIFGFMGFLGFAVVYAMRVNLSVAIVAMVNQTAIPHSNSSVIDTDTCPLPAPHHNGSDPN 128
            |...|:|...|..|||.:.:.:|.||.||||.|||.:.| |....||
  Rat    66 GLPRRYIIAIMSGLGFCISFGIRCNLGVAIVDMVNNSTI-HRGGKVI------------------ 111

  Fly   129 PQKEGEFVWDEATQGLVLGSFFYGYVLTQVPGGRMAELYGGKKIYGYGVLITAVFTLITPLAAHW 193
             :::.:|.||..|.|::.||||:||::||:|||.:|......:::|..:|:|:...::.|.||..
  Rat   112 -KEKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARV 175

  Fly   194 DLPLLVLVRILEGMGEGVTYPAMHAMLAHWIPPLERNKFAAIVYAGSNIGTVISMPLAGWLCSLD 258
            ....::.||||:|:.|||||||.|.:.:.|.|||||::.|...:.||..|.||:|||||.|....
  Rat   176 HYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYT 240

  Fly   259 FLGGWPSAFYIFGLLGILWFIAWMYLVYDKPSDHPRISESEREYIERSLQVQRLINQDLAEAEEE 323
               ||.|.||::|..|::|::.|:.:.|:.|:.||.|::.||.|||.|:
  Rat   241 ---GWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEERRYIEESI---------------- 286

  Fly   324 EGQDEVSLRAPPEEPIPWSSLLTSVPLWAILLTQCGQGWAFYTQLTELPTYMSNILHFDIQSNAL 388
             |:....|.|..:...||....||:|::||::....:.|.||..|...|.|...:..|:|....:
  Rat   287 -GESANLLGAMEKFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGM 350

  Fly   389 LNAVPYLTSWFVGIACSALADWMLARRYISLLNSYKLWNTVASVVPSLGLIGIIYVGCDWVWVTF 453
            |:|||:|....:......:||::.:::.:|.....|:.|.....:.:..|:.:.|.....|.::|
  Rat   351 LSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVRKIMNCGGFGMEATLLLVVGYSHTRGVAISF 415

  Fly   454 MLAGVGSFGGAVYAGNQMNHIALSPRYAGTMYGITNSAANICGFLAPYVIGLIINHRETLTQWHL 518
            ::..|| |.|...:|..:||:.::||||..:.||:|....:.|.:.|.::|.:..:: :..:|..
  Rat   416 LVLAVG-FSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKNK-SREEWQY 478

  Fly   519 VFWLAAGLNIAGNFIYLIFASAEEQSWSKTPPTRNSR 555
            ||.:||.::..|...|.:|||.|:|.|:....|...:
  Rat   479 VFLIAALVHYGGVIFYALFASGEKQPWADPEETSEEK 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS10	NP_001285188.1	2A0114euk	63..547	CDD:129972	157/482 (33%)
MFS10	NP_001285188.1	MFS	134..538	CDD:119392	130/403 (32%)
Slc17a6	NP_445879.1	2A0114euk	70..511	CDD:129972	156/482 (32%)
Slc17a6	NP_445879.1	MFS	75..498	CDD:119392	148/464 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100421
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.710