DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS10 and SLC17A1

DIOPT Version :9

Sequence 1:	NP_001285188.1	Gene:	MFS10 / 32263	FlyBaseID:	FBgn0030452	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	XP_016866688.1	Gene:	SLC17A1 / 6568	HGNCID:	10929	Length:	517	Species:	Homo sapiens

Alignment Length:	491	Identity:	143/491 - (29%)
Similarity:	237/491 - (48%)	Gaps:	59/491 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 GFMGF---LGF------AVVYAMRVNLSVAIVAMVNQTAIPH-----SNSSVIDTDTCPLPAPHH 122
            ||..|   |.|      .::.|.|..|::.:|.|||.|. ||     |...::|.    :..|.:
Human    64 GFCSFRYGLSFLVHCCNVIITAQRACLNLTMVVMVNSTD-PHGLPNTSTKKLLDN----IKNPMY 123

  Fly   123 NGSDPNPQKEGEFVWDEATQGLVLGSFFYGYVLTQVPGGRMAELYGGKKIYGYGVLITAVFTLIT 187
            |             |....||::|.|..||.::.|||.|..:.:|..||:.|:.:.:::|.:|:.
Human   124 N-------------WSPDIQGIILSSTSYGVIIIQVPVGYFSGIYSTKKMIGFALCLSSVLSLLI 175

  Fly   188 PLAAHWDLPLLVLVRILEGMGEGVTYPAMHAMLAHWIPPLERNKFAAIVYAGSNIGTVISMPLAG 252
            |.||...:..:|:.|.::|..:|:...|...:...|.|||||.:..::..:|..:|..|.:.:.|
Human   176 PPAAGIGVAWVVVCRAVQGAAQGIVATAQFEIYVKWAPPLERGRLTSMSTSGFLLGPFIVLLVTG 240

  Fly   253 WLC-SLDFLGGWPSAFYIFGLLGILWFIAWMYLVYDKPSDHPRISESEREYIERSLQVQRLINQD 316
            .:| ||    |||..|||||..|....:.|..|.||.|.|||.||.||:|||..|| ||::
Human   241 VICESL----GWPMVFYIFGACGCAVCLLWFVLFYDDPKDHPCISISEKEYITSSL-VQQV---- 296

  Fly   317 LAEAEEEEGQDEVSLRAPPEEPIPWSSLLTSVPLWAILLTQCGQGWAFYTQLTELPTYMSNILHF 381
                            :...:.:|..::|.|:|:|||........|:........|.:::::||.
Human   297 ----------------SSSRQSLPIKAILKSLPVWAISTGSFTFFWSHNIMTLYTPMFINSMLHV 345

  Fly   382 DIQSNALLNAVPYLTSWFVGIACSALADWMLARRYISLLNSYKLWNTVASVVPSLGLIGIIYVGC 446
            :|:.|..|:::|||.:|..|.....|:|:.|.|..:|::...||:.....::|::..:.:.|:..
Human   346 NIKENGFLSSLPYLFAWICGNLAGQLSDFFLTRNILSVIAVRKLFTAAGFLLPAIFGVCLPYLSS 410

  Fly   447 DWVWVTFMLAGVGSFGGAVYAGNQMNHIALSPRYAGTMYGITNSAANICGFLAPYVIGLIINHRE 511
            .:..:...|...|:.|.....|..:|.:.::|||.|.:...:.....|.|.:|..:.|||:. ::
Human   411 TFYSIVIFLILAGATGSFCLGGVFINGLDIAPRYFGFIKACSTLTGMIGGLIASTLTGLILK-QD 474

  Fly   512 TLTQWHLVFWLAAGLNIAGNFIYLIFASAEEQSWSK 547
            ..:.|...|.|.|.:|:.|...|||.|:||.|.|:|
Human   475 PESAWFKTFILMAAINVTGLIFYLIVATAEIQDWAK 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS10	NP_001285188.1	2A0114euk	63..547	CDD:129972	142/489 (29%)
MFS10	NP_001285188.1	MFS	134..538	CDD:119392	118/404 (29%)
SLC17A1	XP_016866688.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5446
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.760