DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS10 and slc17a8

DIOPT Version :9

Sequence 1:	NP_001285188.1	Gene:	MFS10 / 32263	FlyBaseID:	FBgn0030452	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001076304.1	Gene:	slc17a8 / 563467	ZFINID:	ZDB-GENE-060503-416	Length:	590	Species:	Danio rerio

Alignment Length:	495	Identity:	166/495 - (33%)
Similarity:	264/495 - (53%)	Gaps:	43/495 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 GC-GPKTRHIFGFMGFLGFAVVYAMRVNLSVAIVAMVNQTAIPHSNSSVIDTDTCPLPAPHHNGS 125
            || |...|:|...:..|||.:.:.:|.||.||||.|||...:..:.::|:.      ||
Zfish    68 GCFGLPKRYIIAMLSGLGFCISFGIRCNLGVAIVEMVNNNTVYINGTAVMQ------PA------ 120

  Fly   126 DPNPQKEGEFVWDEATQGLVLGSFFYGYVLTQVPGGRMAELYGGKKIYGYGVLITAVFTLITPLA 190
                    :|.||..|.||:.||||:||::||:|||.::......:::|..:.:|:|..:..|.|
Zfish   121 --------QFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKLAANRVFGAAIFLTSVLNMFIPSA 177

  Fly   191 AHWDLPLLVLVRILEGMGEGVTYPAMHAMLAHWIPPLERNKFAAIVYAGSNIGTVISMPLAGWLC 255
            |......::.||||:|:.|||||||.|.|.:.|.|||||::.|...:.||..|.||:|||||.|
Zfish   178 ARVHYGCVMFVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGIL- 241

  Fly   256 SLDFLGGWPSAFYIFGLLGILWFIAWMYLVYDKPSDHPRISESEREYIERSLQVQRLINQDLAEA 320
             :.:: ||||.|||:|:.||:|:|.|:.|.|:.|:.||.|||.||.|||.|:
Zfish   242 -VQYV-GWPSVFYIYGVFGIIWYIFWILLAYNSPAVHPTISEEERNYIETSI------------- 291

  Fly   321 EEEEGQDEVSLRAPPEEPIPWSSLLTSVPLWAILLTQCGQGWAFYTQLTELPTYMSNILHFDIQS 385
                |:....:.:..:...||....||:|::||::....:.|.||..|...|.|...:..|.|..
Zfish   292 ----GEGANLMSSTEKFKTPWREFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFPISK 352

  Fly   386 NALLNAVPYLTSWFVGIACSALADWMLARRYISLLNSYKLWNTVASVVPSLGLIGIIYVGCDWVW 450
            ..:|:|||::....:......|||::.:|:.:|.....|:.|.....:.:..|:.:.:.....|.
Zfish   353 VGILSAVPHMVMTIIVPIGGQLADFLRSRKILSTTTVRKIMNCGGFGMEATLLLVVGFSHTRAVA 417

  Fly   451 VTFMLAGVGSFGGAVYAGNQMNHIALSPRYAGTMYGITNSAANICGFLAPYVIGLIINHRETLTQ 515
            ::|::..|| |.|...:|..:||:.::||||..:.||:|....:.|.:.|.::|.:..|: |..:
Zfish   418 ISFLILAVG-FSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGALTKHK-TRLE 480

  Fly   516 WHLVFWLAAGLNIAGNFIYLIFASAEEQSWSKTPPTRNSR 555
            |..||.:|:.::..|...|.||||.|:|.|:....|.:.:
Zfish   481 WQHVFVIASMVHYTGVIFYAIFASGEKQDWADPENTSDEK 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS10	NP_001285188.1	2A0114euk	63..547	CDD:129972	164/484 (34%)
MFS10	NP_001285188.1	MFS	134..538	CDD:119392	138/403 (34%)
slc17a8	NP_001076304.1	2A0114euk	75..514	CDD:129972	162/480 (34%)
		MFS	81..503	CDD:119392	154/463 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	526..590
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100421
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.710