DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS10 and CG2003

DIOPT Version :9

Sequence 1:	NP_001285188.1	Gene:	MFS10 / 32263	FlyBaseID:	FBgn0030452	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_651903.2	Gene:	CG2003 / 43761	FlyBaseID:	FBgn0039886	Length:	492	Species:	Drosophila melanogaster

Alignment Length:	501	Identity:	157/501 - (31%)
Similarity:	256/501 - (51%)	Gaps:	65/501 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 PKT------RHIFGFMGFLGFAVVYAMRVNLSVAIVAMVNQTAIPHSNSSVIDTDTCPLPAPHHN 123
            |||      ||:...:.|.|.|....:::|:|||:|||.|:|.   ||:|         ..||:|
  Fly     8 PKTVPRLGLRHLQAGLLFYGLAANTVLQLNVSVAVVAMTNETT---SNNS---------DPPHYN 60

  Fly   124 GSDPNPQKEGEFVWDEATQGLVLGSFFYGYVLTQVPGGRMAELYGGKKIYGYGVLITAVFTLITP 188
                         |.|..:..:|.|:::|..|.|.|.|.:.:.:|.|.:..:|.|.:::.:.:|.
  Fly    61 -------------WSEEKKSYILSSYYWGCALAQFPAGYLCKRFGSKAVLFWGTLGSSLLSALTT 112

  Fly   189 ---LAAHWDLPLLVLVRILEGMGEGVTYPAMHAMLAHWIPPLERNKFAAIVYAGSNIGTVISMPL 250
               .|..|  .....:|:|:|:.: ||:|.:|..||:|.|..||.:..|..|.|.:.|.|::|..
  Fly   113 YGVYAGGW--KAYCAIRLLQGLCQ-VTWPCIHQHLANWCPTAERTRLGAFAYTGFDCGNVLAMYG 174

  Fly   251 AGWLCSLDFLGGWPSAFYIFGLLGILWFIAWMYLVYDKPSDHPRISESEREYIERSLQVQRLINQ 315
            ||.:.|...  |||...|....||::|...|:.|..:|.||...|.|:|:.||...:|
  Fly   175 AGMIASSSL--GWPGISYSAAGLGLIWCGLWLLLGANKASDARFIGEAEKAYIVGDIQ------- 230

  Fly   316 DLAEAEEEEGQDEVSLRAPPEEPIPWSSLLTSVPLWAILLTQCGQGWAFYTQLTELPTYMSNILH 380
                ..|.:|        |.:..|||..:.||||::|:|..:|...|...|..||||||:|.:|.
  Fly   231 ----RSERKG--------PKKMEIPWKGIFTSVPVYALLCARCADSWGLTTMQTELPTYLSGVLK 283

  Fly   381 FDIQSNALLNAVPYLTSWFVGIACSALADWMLARRYISLLNSYKLWNTVASVVPSLGLIGIIYVG 445
            .|::|||:.:|:|:|..|.:......:||.:|.::::||....|.:.::|...|:..::.::.||
  Fly   284 LDMKSNAVFSALPFLLMWVMCYVYLIIADVLLRKKWMSLTTLRKTYTSIALWAPASIMLSLVIVG 348

  Fly   446 CDWVWVTFML----AGVGSFGGAVYAGNQMNHIALSPRYAGTMYGITNSAANICGFLAPYVIGLI 506
            .....:..:|    .||.|   |...|:::|.|.|||.:||.:.|:.:|..|:...|.|.|:|::
  Fly   349 EGQKTLVLVLVTLSVGVSS---AATIGSELNTIDLSPNHAGILAGLMSSFTNLMALLTPLVVGVL 410

  Fly   507 INHRETLTQWHLVFWLAAGLNIAGNFIYLIFASAEEQSWSKTPPTR 552
            :......:||.:||.||||:...||.|:||:.:|..|.|:::..:|
  Fly   411 VTDPSQRSQWQIVFSLAAGVLFTGNVIFLIWGTAVTQPWNESKESR 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS10	NP_001285188.1	2A0114euk	63..547	CDD:129972	156/494 (32%)
MFS10	NP_001285188.1	MFS	134..538	CDD:119392	130/410 (32%)
CG2003	NP_651903.2	2A0114euk	23..456	CDD:129972	151/484 (31%)
CG2003	NP_651903.2	MFS	58..441	CDD:119392	131/422 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I288
eggNOG	1	0.900	-	-		E1_KOG2532
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I245
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	1	1.000	-	-		mtm14983
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X142
	8	7.960