DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS10 and MFS12

DIOPT Version :9

Sequence 1:	NP_001285188.1	Gene:	MFS10 / 32263	FlyBaseID:	FBgn0030452	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_610332.3	Gene:	MFS12 / 35745	FlyBaseID:	FBgn0033234	Length:	477	Species:	Drosophila melanogaster

Alignment Length:	500	Identity:	159/500 - (31%)
Similarity:	250/500 - (50%)	Gaps:	59/500 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 GPKTRHIFGFMGFLGFAVVYAMRVNLSVAIVAMVNQTAIPHSNSSVIDTDTCPLPAPHHNGSDPN 128
            |...||....:.|:|..:.|..|||:|.|||.|...||                .||.
  Fly    14 GLGVRHWQAVLLFVGMMINYFQRVNISAAIVPMTQSTA----------------GAPF------- 55

  Fly   129 PQKEGEFVWDEATQGLVLGSFFYGYVLTQVPGGRMAELYGGKKIYGYGVLITAVFTLITPLAAHW 193
                  :.||.:.:.|:|.|||:|||::|||.|.:|:.:|.|.:.|....|..:.....|:||..
  Fly    56 ------YTWDTSDKSLILSSFFWGYVVSQVPAGLLAKRFGAKLVLGLATAIGGILCFFHPIAAKS 114

  Fly   194 DLPLLVLVRILEGMGEGVTYPAMHAMLAHWIPPLERNKFAAIVYAGSNIGTVISMPLAGWLCSLD 258
            ....:.::|:|.|:.:|..||.:|.:||.|:|..||......||:|:..||.:.:..:|::....
  Fly   115 GWQSICVLRVLTGLVQGTVYPCVHTLLAKWVPRTERGLLTTGVYSGAQFGTAVILVTSGFIFESS 179

  Fly   259 FLGGWPSAFYIFGLLGILWFIAWMYLVYDKPSDHPRISESEREYIERSLQVQRLINQDLAEAEEE 323
            .  |||..||:.|.|.:.|.:.:.:...::|....|||:.|.|||| ||......:|.:
  Fly   180 M--GWPGLFYLSGGLSLAWALLFFWQAANEPVTASRISKGEVEYIE-SLTGSNSSSQSM------ 235

  Fly   324 EGQDEVSLRAPPEEPIPWSSLLTSVPLWAILLTQCGQGWAFYTQLTELPTYMSNILHFDIQSNAL 388
                          |:||.|:..|...:.:|...||..|.|||.|||:|||||.:|..:::|||.
  Fly   236 --------------PVPWMSIFRSPAFYGLLAAHCGFTWGFYTLLTEMPTYMSMVLQLNVKSNAF 286

  Fly   389 LNAVPYLTSWFVGIAC---SALADWMLARRYISLLNSYKLWNTVASVVPSLGLIGIIYVGCD-WV 449
            |:::||..   :|:.|   |.::|.::.|..||:..:.||:|::....|...|||:.|:..| ..
  Fly   287 LSSLPYFA---MGLLCFVVSPISDLLINRGTISITTARKLFNSIGQWGPMACLIGLGYMTADEKT 348

  Fly   450 WVTFMLAGVGSFGGAVYAGNQMNHIALSPRYAGTMYGITNSAANICGFLAPYVIGLIINHRETLT 514
            |...:|............|..:|||.|||.:||.|.|:||..|.:...:||.|:|.|::..|..:
  Fly   349 WAILLLTLAVGINAGCSCGYLINHIDLSPNFAGPMMGVTNGIAGVTSIIAPLVVGAIVSDEEDPS 413

  Fly   515 QWHLVFWLAAGLNIAGNFIYLIFASAEEQSWSKTPPTRNSRSQRA 559
            ||.:||::..|:.:..|.|::||..|..|.|::.|.|.::.:.|:
  Fly   414 QWRMVFFITGGIYLVCNTIFVIFGKATIQIWNEPPSTSSTMTLRS 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS10	NP_001285188.1	2A0114euk	63..547	CDD:129972	156/486 (32%)
MFS10	NP_001285188.1	MFS	134..538	CDD:119392	134/407 (33%)
MFS12	NP_610332.3	MFS	23..436	CDD:119392	148/467 (32%)
MFS12	NP_610332.3	2A0114euk	25..447	CDD:129972	153/476 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I288
eggNOG	1	0.900	-	-		E1_KOG2532
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	134	1.000	Inparanoid score	I245
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	1	1.000	-	-		mtm14983
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X142
	8	7.960