DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS10 and SLC17A8

DIOPT Version :9

Sequence 1:	NP_001285188.1	Gene:	MFS10 / 32263	FlyBaseID:	FBgn0030452	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_647480.1	Gene:	SLC17A8 / 246213	HGNCID:	20151	Length:	589	Species:	Homo sapiens

Alignment Length:	522	Identity:	174/522 - (33%)
Similarity:	274/522 - (52%)	Gaps:	49/522 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 ERSDDEADDEREAFCSGE--RPL--IRSSGAAEENHGCGPKTRHIFGFMGFLGFAVVYAMRVNLS 90
            :|..|...:|.:.....|  ||:  .|.|....:.|.||...|:|...|..|||.:.:.:|.||.
Human    33 QRKIDGTTEEEDNIELNEEGRPVQTSRPSPPLCDCHCCGLPKRYIIAIMSGLGFCISFGIRCNLG 97

  Fly    91 VAIVAMVNQTAIPHSNSSVIDTDTCPLPAPHHNGSDPNPQ-KEGEFVWDEATQGLVLGSFFYGYV 154
            ||||.|||       ||:|.              .|..|: :..:|.||..|.||:.||||:||:
Human    98 VAIVEMVN-------NSTVY--------------VDGKPEIQTAQFNWDPETVGLIHGSFFWGYI 141

  Fly   155 LTQVPGGRMAELYGGKKIYGYGVLITAVFTLITPLAAHWDLPLLVLVRILEGMGEGVTYPAMHAM 219
            :||:|||.::..:...:::|..:.:|:...:..|.||......::.||||:|:.|||||||.|.|
Human   142 MTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYGCVMCVRILQGLVEGVTYPACHGM 206

  Fly   220 LAHWIPPLERNKFAAIVYAGSNIGTVISMPLAGWLCSLDFLGGWPSAFYIFGLLGILWFIAWMYL 284
            .:.|.|||||::.|...:.||..|.|::|||||.|  :.:: ||.|.|||:|:.||:|::.|:..
Human   207 WSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVL--VQYI-GWSSVFYIYGMFGIIWYMFWLLQ 268

  Fly   285 VYDKPSDHPRISESEREYIERSLQVQRLINQDLAEAEEEEGQDEVSLRAPPEEPIPWSSLLTSVP 349
            .|:.|:.||.||..|:.|||.|:               .||.:.|||   .:...||....||:|
Human   269 AYECPAAHPTISNEEKTYIETSI---------------GEGANVVSL---SKFSTPWKRFFTSLP 315

  Fly   350 LWAILLTQCGQGWAFYTQLTELPTYMSNILHFDIQSNALLNAVPYLTSWFVGIACSALADWMLAR 414
            ::||::....:.|.||..|...|.|...:..|.|....||:|||::....|......|||::.:|
Human   316 VYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRSR 380

  Fly   415 RYISLLNSYKLWNTVASVVPSLGLIGIIYVGCDWVWVTFMLAGVGSFGGAVYAGNQMNHIALSPR 479
            :.::.....|:.|.....:.:..|:.:.:.....|.::|::..|| |.|...:|..:||:.::||
Human   381 QILTTTAVRKIMNCGGFGMEATLLLVVGFSHTKGVAISFLVLAVG-FSGFAISGFNVNHLDIAPR 444

  Fly   480 YAGTMYGITNSAANICGFLAPYVIGLIINHRETLTQWHLVFWLAAGLNIAGNFIYLIFASAEEQS 544
            ||..:.||:|....:.|.:.|.::|.:..|: |..:|..||.:||.::.:|...|.:|||.|:|.
Human   445 YASILMGISNGVGTLSGMVCPLIVGAMTRHK-TREEWQNVFLIAALVHYSGVIFYGVFASGEKQE 508

  Fly   545 WS 546
            |:
Human   509 WA 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS10	NP_001285188.1	2A0114euk	63..547	CDD:129972	165/485 (34%)
MFS10	NP_001285188.1	MFS	134..538	CDD:119392	136/403 (34%)
SLC17A8	NP_647480.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..61		5/20 (25%)
		2A0114euk	75..513	CDD:129972	163/480 (34%)
		MFS	80..502	CDD:119392	155/465 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	559..589
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100421
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.710