DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MFS10 and cima-1

DIOPT Version :9

Sequence 1:	NP_001285188.1	Gene:	MFS10 / 32263	FlyBaseID:	FBgn0030452	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001294208.1	Gene:	cima-1 / 24104589	WormBaseID:	WBGene00018473	Length:	543	Species:	Caenorhabditis elegans

Alignment Length:	540	Identity:	129/540 - (23%)
Similarity:	225/540 - (41%)	Gaps:	86/540 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 PSTSSNSSASAERSDDEADDEREAFCSGERPLIRSSGAAEENHGCGPKTRHIFGFMGFLGFAVVY 83
            |||::.|::.|  :||::.||..:..|...|.:|...||                |....|..:.
Worm    36 PSTNNGSTSMA--ADDQSQDEEHSAHSVLFPSMRLMLAA----------------MLCCCFITLS 82

  Fly    84 AMRVNLSVAIVAMVNQTAIPHSNSSVIDTDTCPLPAPHHNGSDPNPQKEGEFVWDEATQGLVLGS 148
            ....||:||::.|.                :||:   |..|        |...|....:||||.:
Worm    83 ISSSNLAVALICMT----------------SCPV---HGYG--------GTLEWQSQQEGLVLAA 120

  Fly   149 FFYGYVLTQVPGGRMAELYGGKKIYGYGVLITAVFTLITPLAAHWDLPLLVLVRILEGMGEGVTY 213
            ...| .|..:..|..|:...||.:...|:|:..:..|:.||.|.......||.||..|..:....
Worm   121 QNAG-SLIMIVTGMWADRLNGKWMVFIGLLLCCIGNLMLPLLASKSFWFAVLARISIGASDACLM 184

  Fly   214 PAMHAMLAHWIPPLERNKFAAIVYAGSNIGTVISMPLAGWLCS-LDFLGGWPSAFYIFGLLGILW 277
            ||:::::..|.|..||.....::..|..|||:..:|.||:||: .|.|.|||:.||:...:.:|.
Worm   185 PAVNSLITRWFPQAERPAAIGLISGGRQIGTLFILPTAGYLCTRKDILDGWPAIFYLSATISVLV 249

  Fly   278 FIAWMYLVYDKPSDHPRISESEREYIERSLQVQRLINQDLAEAEEEEGQDEVSLRAPPEEPIPWS 342
            .:.|:....|||:....||..|:|:||..:..                 :.:..|......:|:.
Worm   250 TVFWIPFGADKPAKQICISSREKEFIETRIAC-----------------ESIGKRTDRTRRVPYG 297

  Fly   343 SLLTSVPLWAILLTQCGQGWAFYTQLTELPTYMSNILHFDIQSNALLNAVPYLTSWFVGIACSAL 407
            ::|.|.||||.:.......:.....|..||.||.::|.|....|.::.|:|.|..:......|:|
Worm   298 AMLHSKPLWACIFALICHEYPLVIMLQFLPNYMRDVLEFAPTKNGIIAALPILCLFLSKTFSSSL 362

  Fly   408 ADWMLARRYISLLNSYKLWNTVASVVPSLGLIGIIYVGCDWVWV-TFMLAGVGSFGGAVYAGNQM 471
            :.::..:..:......|.:|.|||...::.:..:.:...:..:: .|.|.|...|.|....|...
Worm   363 SSYLTTKLRLDKTFVCKGFNAVASAGLAICISFVPFFNKESAFLAVFCLCGAMIFAGLHTPGVIT 427

  Fly   472 NHIALSPRYAGTMYG----------ITNSAANICGFLAPYVIGLIINHRETLTQWHLVFWLAAGL 526
            ..:.::|.::|.:.|          |.|.      .|..|::     ...::|:|.:||.::|.:
Worm   428 AMVQIAPAFSGIITGWSFFAVAWFSIGNK------ILTKYIV-----QSGSVTEWGMVFRVSALV 481

  Fly   527 NIAGNFIYLIFASAEEQSWS 546
            ......::.|:.||:.:.|:
Worm   482 AALPVIVFTIWGSADREWWA 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS10	NP_001285188.1	2A0114euk	63..547	CDD:129972	115/496 (23%)
MFS10	NP_001285188.1	MFS	134..538	CDD:119392	100/415 (24%)
cima-1	NP_001294208.1	2A0114euk	63..506	CDD:129972	119/511 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28615
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X142
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920