DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS10 and Slc17a8

DIOPT Version :9

Sequence 1:	NP_001285188.1	Gene:	MFS10 / 32263	FlyBaseID:	FBgn0030452	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_892004.1	Gene:	Slc17a8 / 216227	MGIID:	3039629	Length:	601	Species:	Mus musculus

Alignment Length:	485	Identity:	165/485 - (34%)
Similarity:	260/485 - (53%)	Gaps:	45/485 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 CGPKTRHIFGFMGFLGFAVVYAMRVNLSVAIVAMVNQTAIPHSNSSVIDTDTCPLPAPHHNGSDP 127
            ||...|:|...|..|||.:.:.:|.||.||||.|||       ||:|.              .|.
Mouse    83 CGIPKRYIIAVMSGLGFCISFGIRCNLGVAIVEMVN-------NSTVY--------------VDG 126

  Fly   128 NPQ-KEGEFVWDEATQGLVLGSFFYGYVLTQVPGGRMAELYGGKKIYGYGVLITAVFTLITPLAA 191
            .|: :..:|.||..|.||:.||||:||::||:|||.::..:...:::|..:.:|:...:..|.||
Mouse   127 KPEIQTAQFNWDPETVGLIHGSFFWGYIVTQIPGGFISNKFAASRVFGAAIFLTSTLNMFIPSAA 191

  Fly   192 HWDLPLLVLVRILEGMGEGVTYPAMHAMLAHWIPPLERNKFAAIVYAGSNIGTVISMPLAGWLCS 256
            ......::.||||:|:.|||||||.|.|.:.|.|||||::.|...:.||..|.|::|||||.|
Mouse   192 RVHYGCVMGVRILQGLVEGVTYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVL-- 254

  Fly   257 LDFLGGWPSAFYIFGLLGILWFIAWMYLVYDKPSDHPRISESEREYIERSLQVQRLINQDLAEAE 321
            :.:: ||.|.|||:|:.||:|::.|:...|:.|:.||.||.:||.|||.|:
Mouse   255 VQYI-GWASVFYIYGMFGIIWYMFWLLQAYECPAAHPTISNAERTYIETSI-------------- 304

  Fly   322 EEEGQDEVSLRAPPEEPIPWSSLLTSVPLWAILLTQCGQGWAFYTQLTELPTYMSNILHFDIQSN 386
             .||.:..||   .:...||....||:|::||::....:.|.||..|...|.|...:..|.|...
Mouse   305 -GEGANLASL---SKFNTPWRRFFTSLPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFAISKV 365

  Fly   387 ALLNAVPYLTSWFVGIACSALADWMLARRYISLLNSYKLWNTVASVVPSLGLIGIIYVGCDWVWV 451
            .||:|||::....|......|||::.:|:.::.....|:.|.....:.:..|:.:.:.....|.:
Mouse   366 GLLSAVPHMVMTIVVPIGGQLADYLRSRKILTTTAVRKIMNCGGFGMEATLLLVVGFSHTKGVAI 430

  Fly   452 TFMLAGVGSFGGAVYAGNQMNHIALSPRYAGTMYGITNSAANICGFLAPYVIGLIINHRETLTQW 516
            :|::..|| |.|...:|..:||:.::||||..:.||:|....:.|.:.|.::|.:..|: |..:|
Mouse   431 SFLVLAVG-FSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTKHK-TREEW 493

  Fly   517 HLVFWLAAGLNIAGNFIYLIFASAEEQSWS 546
            ..||.:||.::.:|...|.:|||.|:|.|:
Mouse   494 QNVFLIAALVHYSGVIFYGVFASGEKQDWA 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS10	NP_001285188.1	2A0114euk	63..547	CDD:129972	165/485 (34%)
MFS10	NP_001285188.1	MFS	134..538	CDD:119392	136/403 (34%)
Slc17a8	NP_892004.1	2A0114euk	88..526	CDD:129972	163/480 (34%)
		MFS	93..515	CDD:119392	155/465 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	576..601
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100421
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.710