DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MFS10 and slc-17.7

DIOPT Version :9

Sequence 1:	NP_001285188.1	Gene:	MFS10 / 32263	FlyBaseID:	FBgn0030452	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_505399.1	Gene:	slc-17.7 / 179308	WormBaseID:	WBGene00022788	Length:	506	Species:	Caenorhabditis elegans

Alignment Length:	501	Identity:	124/501 - (24%)
Similarity:	205/501 - (40%)	Gaps:	75/501 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 LGFAVVYAMRVNLSVAIVAMVNQTAIPHSNSSVIDTDT--------CPLPAPHHNGSDPNPQKEG 133
            |...:...||.||::|||.|:|.||:......:...:|        |||   ...|.....:.:|
Worm    23 LALTIEGLMRSNLNMAIVCMLNSTALTDGKPMIASLNTSIEPATPLCPL---LQFGESKVVEHKG 84

  Fly   134 EFVWDEATQGLVLGSFFYG--------YVLTQVPGGRMAELYGGKKIYGYGVLITAVFTLITPLA 190
            ...|....:.::..:|:.|        .||.:..|...:.||||        :...|.|.:||..
Worm    85 TIFWTSQDRAIIFAAFYAGGLVATLASEVLNRYIGATRSVLYGG--------IANVVGTFLTPFV 141

  Fly   191 A---HWDLPLLVLVRILEGMGEGVTYPAMHAMLAHWIPPLERNKFAAIVYAGSNIGTVISMPLAG 252
            |   ::....::|:|.:.|.|:||.:|.|..::|.|.|..|::...||...|:.:..||:|....
Worm   142 ASQTNFGTFPIILLRFVMGFGQGVLWPCMLVLIAQWFPVNEKSTALAIATTGNQLSVVIAMFATA 206

  Fly   253 WLCSLDFLGGWPSAFYIFGLLGILWFIAWMYLVYDKPSD-HPRISESEREYIERSLQVQRLINQD 316
            .||.|.:  |||.||:::.:.||:..|.|..:|||.|.. ..::|..|..||.
Worm   207 ELCQLPW--GWPMAFHVYAVCGIVMCIIWYMMVYDSPCHADKKLSRDELHYIT------------ 257

  Fly   317 LAEAEEEEGQDEVSLRAPPEEPIPWSSLLTSVPLWAILLTQCGQGWAFYTQLTELPTYMSNILHF 381
                     .:.|.||  |:.| .|.:|:.|..:|||..:.....:.....:|.||.|...:|:.
Worm   258 ---------TERVRLR--PQHP-NWMALMKSPVVWAIAASSFAHNYVTVGTITYLPLYYKTVLNM 310

  Fly   382 DIQSNALLNAVPYLTS-----WFVGIACSA-LADWMLARRYISLLNSYKLWNTVASVVPSLGLIG 440
            .:.||.|.:|:|::..     ::.|:|.|| ..||....|.....||    :....:....||:.
Worm   311 SLTSNGLWSALPFVLQLISKVFYAGMAESARKRDWSDINRITKFCNS----SASFGIAICFGLLC 371

  Fly   441 IIYVGCDWVW---VTFMLAGVGSFGGAVYAGNQMNHIALSPRYAGTMYGITNSAANICGFLAPYV 502
            :    ||...   ..|::.....|......|...:.:.::|.....:...:.....|...:|||.
Worm   372 L----CDCSQRGAAIFLICLAMCFVSGYIPGYNTSAVTIAPGQTAAIAAFSRFWGQIASSVAPYH 432

  Fly   503 IGLIINHRETLTQWHLVFWLAAGLNIAGNFIYLIFASAEEQSWSKT 548
            || ....:.|..:|.:||.:.|.:.:.....:....:|..|.|..|
Worm   433 IG-AYTKQGTADEWKIVFAVIAAICVVTGIFFQCCGTASLQDWDST 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS10	NP_001285188.1	2A0114euk	63..547	CDD:129972	123/498 (25%)
MFS10	NP_001285188.1	MFS	134..538	CDD:119392	102/424 (24%)
slc-17.7	NP_505399.1	MFS	31..467	CDD:391944	119/481 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28615
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X142
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920