DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS10 and slc-17.8

DIOPT Version :9

Sequence 1:	NP_001285188.1	Gene:	MFS10 / 32263	FlyBaseID:	FBgn0030452	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001023848.1	Gene:	slc-17.8 / 179234	WormBaseID:	WBGene00017798	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	571	Identity:	150/571 - (26%)
Similarity:	259/571 - (45%)	Gaps:	96/571 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 YDPSTSSNSSASAERSDDEADDEREAFCSGERPLIRSSGAAEENHGCGPKTRHIFGFMGFLGFAV 81
            ||.:..|.....  ||........:...|.:|||         .:...|..|.:...|....|..
Worm    13 YDDAAKSPDQLL--RSMSSVHPISDGIPSQQRPL---------TYRWFPSWRFMTSIMLCFCFGC 66

  Fly    82 VYAMRVNLSVAIVAMVNQTAIPHSNSSVIDTDTCPLPAPHHNGSDPNPQKEGEFVWDEATQGLVL 146
            |:.|..|:.:|||.|||       :|:..|.:|.|        .:..|..:    |....||.:.
Worm    67 VHLMNSNMGMAIVCMVN-------SSATYDNETYP--------ENAAPLLD----WSSDEQGYIF 112

  Fly   147 GSFFYGYVLTQVPGGRMAELYGGKKIYGYGVLIT------AVFTL--ITPLAAHWDLPLLVLVRI 203
            .:|..|.::....|| ||:.:..|    |.:|::      |.|||  :.|::.:|    .:..|.
Worm   113 SAFNAGLLVMLFTGG-MADKFNAK----YMILVSVAIASLANFTLPWMAPISVYW----AIFSRF 168

  Fly   204 LEGMGEGVTYPAMHAMLAHWIPPLERNKFAAIVYAGSNIGTVISMPLAGWLCS-LDFLGGWPSAF 267
            |.|..:.:..|||::::..|.|..||:....:...|..|||:|.:|.||.||| .:..|||||.|
Worm   169 LVGFADALLQPAMNSLITRWFPTSERSYALGLATGGRQIGTLIIIPAAGALCSQTEIFGGWPSIF 233

  Fly   268 YIFGLLGILWFIAWMYLVYDKPSDHPRISESEREYIERSLQVQRLINQDLAEAEEEEGQDEVSLR 332
            |:.|.:|:|:..::::|..||||....||::|.::|..|.|            .|:.|:...
Worm   234 YLSGFIGVLFIFSYIFLGADKPSKQSCISDNELKFITISNQ------------SEDVGKKRT--- 283

  Fly   333 APPEEPIPWSSLLTSVPLWAILLTQCGQGWAFYTQLTELPTYMSNILHFDIQSNALLNAVPYLTS 397
               |..:||.::|.|..:||.:::.....:...|.:..||:|:.::.|:....|.:|:|:|.::.
Worm   284 ---ERKVPWKNILKSGAVWASVISLVCHEFPLMTLIMFLPSYLHDVHHYHSTENGILSALPTVSL 345

  Fly   398 WFVGIACSALADWMLARRYISLLNSYKLW--NTVASVVPSLGLIGI-IYVGC--------DWVWV 451
            ||..|..|.|..|         |.....|  :|:..|:.|:|.||: :::..        .|:.|
Worm   346 WFAKIGSSYLNTW---------LQKNTTWKKDTICKVLNSIGSIGLGVFLLAATFLDNEHAWMAV 401

  Fly   452 TFMLAGVGSFGGAVYAGNQMNHIALSPRYAGTMYGITNSAANICGFLAPYVIGLIINHRETLTQW 516
            .|:...:.| .|....|.|:..::::|.|:|.:.|.|.....:.|.:.|.:..:|:..| |..:|
Worm   402 LFLCLSMAS-AGLHTPGCQLALVSVAPAYSGAVTGFTFFFVAVSGIIHPIITKMIVKDR-TAAEW 464

  Fly   517 HLVFWLAAGLNIAGNFIYLIFASAEEQSWSKTPPT--------RNSRSQRA 559
            :|||:::..:.|....|:.::.|.|.|.|:|:..:        :.|:|.:|
Worm   465 NLVFYISTVIAIFPIIIFNVWGSTEVQWWAKSKASMQQEPNNKKMSKSSKA 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS10	NP_001285188.1	2A0114euk	63..547	CDD:129972	137/503 (27%)
MFS10	NP_001285188.1	MFS	134..538	CDD:119392	115/423 (27%)
slc-17.8	NP_001023848.1	MFS_SLC17	57..486	CDD:340876	131/485 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28615
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X142
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.020