DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS10 and Slc17a7

DIOPT Version :9

Sequence 1:	NP_001285188.1	Gene:	MFS10 / 32263	FlyBaseID:	FBgn0030452	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	XP_038966881.1	Gene:	Slc17a7 / 116638	RGDID:	620101	Length:	585	Species:	Rattus norvegicus

Alignment Length:	501	Identity:	162/501 - (32%)
Similarity:	264/501 - (52%)	Gaps:	51/501 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 GPKTRHIFGFMGFLGFAVVYAMRVNLSVAIVAMVNQTAIPHSNSSVIDTDTCPLPAPHH------ 122
            |...|:|...|..|||.:.:.:|.||.||||:|||.:........|:.|   |..:.|.
  Rat    58 GLPRRYIIAIMSGLGFCISFGIRCNLGVAIVSMVNNSTTHRGGHVVVQT---PYRSVHKQEAVTP 119

  Fly   123 -----NGSDPNPQKEGEFVWDEATQGLVLGSFFYGYVLTQVPGGRMAELYGGKKIYGYGVLITAV 182
                 .|.|   .::.:|.||..|.||:.||||:||::||:|||.:.:.:...:::|:.::.|:.
  Rat   120 TVGDIQGGD---TEKAQFNWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRVFGFAIVATST 181

  Fly   183 FTLITPLAAHWDLPLLVLVRILEGMGEGVTYPAMHAMLAHWIPPLERNKFAAIVYAGSNIGTVIS 247
            ..::.|.||......::.||||:|:.|||||||.|.:.:.|.|||||::.|...:.||..|.|::
  Rat   182 LNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTAFCGSYAGAVVA 246

  Fly   248 MPLAGWLCSLDFLGGWPSAFYIFGLLGILWFIAWMYLVYDKPSDHPRISESEREYIERSL-QVQR 311
            |||||.|..   ..||.|.||::|..||.|::.|:.:.|:.|:.||.|||.||:|||.:: :..:
  Rat   247 MPLAGVLVQ---YSGWSSVFYVYGSFGIFWYLFWLLVSYESPALHPSISEEERKYIEDAIGESAK 308

  Fly   312 LINQDLAEAEEEEGQDEVSLRAPPEEPI-----PWSSLLTSVPLWAILLTQCGQGWAFYTQLTEL 371
            |:|                       |:     ||....||:|::||::....:.|.||..|...
  Rat   309 LMN-----------------------PVTKFNTPWRRFFTSMPVYAIIVANFCRSWTFYLLLISQ 350

  Fly   372 PTYMSNILHFDIQSNALLNAVPYLTSWFVGIACSALADWMLARRYISLLNSYKLWNTVASVVPSL 436
            |.|...:..|:|....|::|:|:|....:......:||::.:|..:|..|..||.|.....:.:.
  Rat   351 PAYFEEVFGFEISKVGLVSALPHLVMTIIVPIGGQIADFLRSRHIMSTTNVRKLMNCGGFGMEAT 415

  Fly   437 GLIGIIYVGCDWVWVTFMLAGVGSFGGAVYAGNQMNHIALSPRYAGTMYGITNSAANICGFLAPY 501
            .|:.:.|.....|.::|::..|| |.|...:|..:||:.::||||..:.||:|....:.|.:.|.
  Rat   416 LLLVVGYSHSKGVAISFLVLAVG-FSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPI 479

  Fly   502 VIGLIINHRETLTQWHLVFWLAAGLNIAGNFIYLIFASAEEQSWSK 547
            ::|.:..|: |..:|..||.:|:.::..|...|.:|||.|:|.|::
  Rat   480 IVGAMTKHK-TREEWQYVFLIASLVHYGGVIFYGVFASGEKQPWAE 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS10	NP_001285188.1	2A0114euk	63..547	CDD:129972	162/499 (32%)
MFS10	NP_001285188.1	MFS	134..538	CDD:119392	133/409 (33%)
Slc17a7	XP_038966881.1	MFS_SLC17A6_7_8_VGluT	66..515	CDD:340940	153/482 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100421
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810