Protein Alignment HOXC10 and abd-A

DIOPT Version :10

• Sequence 1: NP_059105.2
• Gene: HOXC10 / 3226
• HGNCID: 5122
• Length: 342
• Species: Homo sapiens
• Sequence 2: NP_732176.1
• Gene: abd-A / 42037
• FlyBaseID: FBgn0000014
• Length: 590
• Species: Drosophila melanogaster
• Alignment Length: 451
• Identity: 107/451 - (23%)
• Similarity: 160/451 - (35%)
• Gaps: 141/451 - (31%)

Human     9 PNSYAEPLAAPGGGERYSRSAGMYMQSGSDFN-CGVMRGCGLAPSLSKRDEGSSPSLALNT---- 68
            |||.:..:||.......|.||.:...|.|:.| ...:.|...:   :..:..||||.:.|.
  Fly    30 PNSSSAAVAAALAAAAASASASVSASSSSNNNSSNTIAGSNTS---NTNNSSSSPSSSSNNNSNL 91

Human    69 -------YPSYLSQLDSWGDPKAAYRLEQPVGRPLSSCS----YPPSVKEENV------------ 110
                   .||:|||           .|.|....|:||.|    :.|.|:::::
  Fly    92 NLSGGSLSPSHLSQ-----------HLGQSPHSPVSSSSPFQQHHPQVQQQHLNHQQQQHLHHQQ 145

Human   111 ---CCMYSAEKRAKSGPEAALYSHPLPESCLGEHE-------VPVPSYYRASPSYSALDKTPHCS 165
               ...||:...|....:...:...|..:.:..|.       :..||...:....|:...:|..|
  Fly   146 QQHHHQYSSLSAALQLQQQQHHISKLAAAAVASHGHAHQQLLLTPPSAGNSQAGDSSCSPSPSAS 210

Human   166 GA-------NDFEAPFEQRASLNPRA-------------------------------EHLES-PQ 191
            |:       || .:|....||.:..|                               .|..| ..
  Fly   211 GSSSLHRSLND-NSPGSASASASASAASSVAAAAAAAAAAASSSFAIPTSKMYPYVSNHPSSHGG 274

Human   192 LGGKVSFPETPKSDSQTPSPNEIKTEQSLAGPKGSPSESEK--ERAKAA--------------DS 240
            |.|...|...........:...:.:.||::.|..:.::..:  :.|.||              ||
  Fly   275 LSGMAGFTGLEDKSCSRYTDTVMNSYQSMSVPASASAQFAQFYQHATAAASAVSAASAGAIGVDS 339

Human   241 SPDTSDNEAKEEIKAENTTGN----------WLT------------------AKSG---RKKRCP 274
            ..:.....|...:......|.          |:|                  ..:|   |:.|..
  Fly   340 LGNACTQPASGVMPGAGGAGGAGIADLPRYPWMTLTDWMGSPFERVVCGDFNGPNGCPRRRGRQT 404

Human   275 YTKHQTLELEKEFLFNMYLTRERRLEISKTINLTDRQVKIWFQNRRMKLKKMNRENRIREL 335
            ||:.|||||||||.||.||||.||:||:..:.||:||:|||||||||||||..|  .::|:
  Fly   405 YTRFQTLELEKEFHFNHYLTRRRRIEIAHALCLTERQIKIWFQNRRMKLKKELR--AVKEI 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXC10	NP_059105.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29		6/19 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	187..271		18/131 (14%)
		Homeodomain	269..325	CDD:459649	38/55 (69%)
abd-A	NP_732176.1	Homeodomain	399..455	CDD:459649	38/55 (69%)
		Abdominal-A	456..478	CDD:403567	2/10 (20%)