Protein Alignment HOXC10 and NK7.1

DIOPT Version :10

• Sequence 1: NP_059105.2
• Gene: HOXC10 / 3226
• HGNCID: 5122
• Length: 342
• Species: Homo sapiens
• Sequence 2: NP_650357.2
• Gene: NK7.1 / 41747
• FlyBaseID: FBgn0024321
• Length: 721
• Species: Drosophila melanogaster
• Alignment Length: 437
• Identity: 95/437 - (21%)
• Similarity: 150/437 - (34%)
• Gaps: 147/437 - (33%)

Human     1 MTC-------PRNVTPNSYAEPLAAPGGGERYSRSAGMYMQSGSDFNCGVMRGCGLAPSLSKRDE 58
            |.|       |..:.|.|....:.:|.|..:..                      |...|..||.
  Fly    69 MACNGYNYSSPLTIPPTSMTTHMVSPIGNSKEK----------------------LVNMLRVRDN 111

Human    59 GSSPSLALNTYPSYLSQLDSWGDPKAAYRLEQPVGRPLSSCSYPPSVKEENVCCMYSAEKRAKSG 123
            .:..|...::.|:...|          .:||..|. |..|..:|...:.:........::|:.|.
  Fly   112 NNMASTISDSPPTTFLQ----------KQLEAVVA-PRPSSVHPQHQQPQQQTVQLQQQRRSVST 165

Human   124 P------------EAALYS----HPLPES---CLG----EHEVPVPSYYRASPSYSALDKTPH-- 163
            |            .|.:|.    ||.|.|   .||    :.|.|..::....|:     |:|:
  Fly   166 PAITTTPGPPTNWHAHVYDRLPPHPTPHSIADILGMSFVKKERPEVAFDAQGPA-----KSPNSI 225

Human   164 ----------------CSGANDFEA---------------------------PFEQ--------- 176
                            .|.|::.|:                           |.:|
  Fly   226 LKPYQEQQPIRSSSISMSDASEEESAAVAGATSAATAAAAVAATITAATVATPLDQPLNLCVVKK 290

Human   177 -RASLNPRAEHLESPQLGGKVSFPETPKSDSQTPSPNEIKTEQSLA-----GPKGSPSESEKERA 235
             |.|.|......:..|:.||.:   |.|..|..|:..:.|...::|     .|.||.....:::.
  Fly   291 SRDSNNSPMPATKQSQILGKSA---TKKESSGKPAAKKKKLSSTVALPPDISPTGSSDSLMRDKL 352

Human   236 KAADSSPDTSDNEAKEEIKAENT---------TGNWLTAKSGRKKRCPYTKHQTLELEKEFLFNM 291
            .|.:||...|:..|:.:..|.:|         :|: ..|:..:|.|..:|..|..||||.|....
  Fly   353 MANNSSSPGSNVNAQMQSNANSTLETTEDDSDSGS-TDARRKKKARTTFTGRQIFELEKMFENKK 416

Human   292 YLTRERRLEISKTINLTDRQVKIWFQNRRMKLKKMNRENRIRELTSN 338
            ||:...|.|::|.:.:|:.||||||||||.|.||.:      .:|:|
  Fly   417 YLSASERTEMAKLLMVTETQVKIWFQNRRTKWKKQD------NVTNN 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXC10	NP_059105.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29		7/34 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	187..271		21/97 (22%)
		Homeodomain	269..325	CDD:459649	26/55 (47%)
NK7.1	NP_650357.2	Homeodomain	394..450	CDD:459649	26/55 (47%)