Protein Alignment HOXC10 and Scr

DIOPT Version :10

• Sequence 1: NP_059105.2
• Gene: HOXC10 / 3226
• HGNCID: 5122
• Length: 342
• Species: Homo sapiens
• Sequence 2: NP_001368995.1
• Gene: Scr / 40833
• FlyBaseID: FBgn0003339
• Length: 564
• Species: Drosophila melanogaster
• Alignment Length: 382
• Identity: 99/382 - (25%)
• Similarity: 148/382 - (38%)
• Gaps: 81/382 - (21%)

Human     4 PRNVTPNSYAEPLAAPGGGERYSRSAGMYMQSGSDFNCGVMRGCGLAPSLSKRDEGSSPSLAL-- 66
            |:...|.:........|||   :..:|..:.||     |...|.|.|.:.:.......|:.|.
  Fly    27 PQQNHPGAGNSSAGGSGGG---AGGSGGVVPSG-----GTNGGQGSAGAATPGANDYFPAAAAYT 83

Human    67 -NTYPS-----YLSQ--LDSWGDPKAA-YRLEQPVGRPLSSCSYPPSVKEENVCCMYSAEKRAKS 122
             |.||:     |.:|  ....|:|... |...||....|.........:..:.....:|:::
  Fly    84 PNLYPNTPQAHYANQAAYGGQGNPDMVDYTQLQPQRLLLQQQQQQQQQQHAHAAAAVAAQQQ--- 145

Human   123 GPEAALYSHPLPESCLGEHEVPVPSYYRASPSYSALDKTPHCSGANDFEAPFEQRASLNP---RA 184
             .:.|...||..:.  .:.:..:...|...|      .||..||............|.|.   .:
  Fly   146 -QQLAQQQHPQQQQ--QQQQANISCKYANDP------VTPGGSGGGGVSGSNNNNNSANSNNNNS 201

Human   185 EHLESPQ-LGGKVSFPE-TPKS--DSQTPSPNEIKTEQSLA------------------------ 221
            :.|.||| |..:...|: :|.|  :|...|.|:.....|||
  Fly   202 QSLASPQDLSTRDISPKLSPSSVVESVARSLNKGVLGGSLAAAAAAAGLNNNHSGSGVSGGPGNV 266

Human   222 -----GPKGSPSESEKERAKAADSSPDTSDNE----------AKEEIKAENTTGNWLTAKSGRKK 271
                 .|.|..|:||.:....|.||.::.:.:          .:..:.......|..|    :::
  Fly   267 NVPMHSPGGGDSDSESDSGNEAGSSQNSGNGKKNPPQIYPWMKRVHLGTSTVNANGET----KRQ 327

Human   272 RCPYTKHQTLELEKEFLFNMYLTRERRLEISKTINLTDRQVKIWFQNRRMKLKKMNR 328
            |..||::|||||||||.||.||||.||:||:..:.||:||:||||||||||.||.::
  Fly   328 RTSYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKEHK 384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXC10	NP_059105.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29		5/24 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	187..271		24/126 (19%)
		Homeodomain	269..325	CDD:459649	36/55 (65%)
Scr	NP_001368995.1	Homeodomain	325..381	CDD:459649	36/55 (65%)