Protein Alignment HOXC10 and lab

DIOPT Version :10

• Sequence 1: NP_059105.2
• Gene: HOXC10 / 3226
• HGNCID: 5122
• Length: 342
• Species: Homo sapiens
• Sequence 2: NP_476613.1
• Gene: lab / 40817
• FlyBaseID: FBgn0002522
• Length: 629
• Species: Drosophila melanogaster
• Alignment Length: 337
• Identity: 78/337 - (23%)
• Similarity: 117/337 - (34%)
• Gaps: 105/337 - (31%)

Human     4 PRNVTP---NSYAEPLAAPGGGERYSRSAGMYMQSGSDFNCGVMRGCGLAPSLSKRDEGSSPSLA 65
            |:|.:|   ..:.:...:|.||....:..|: :..||..:.......|..|: |.:.:..:.|.:
  Fly   326 PQNQSPAAHQQHHQNSVSPNGGMNRQQRGGV-ISPGSSTSSSTSASNGAHPA-STQSKSPNHSSS 388

Human    66 LNTYPSYLSQLDSWGDPKAAYRLEQPVGRPLSSCSYPPSVKEENVCCMYSAEKRAKSGPEAALYS 130
            :.||        .|      .:|::.|.:|.:     |.:....:..|:..:...:.
  Fly   389 IPTY--------KW------MQLKRNVPKPQA-----PKLPASGIASMHDYQMNGQL-------- 426

Human   131 HPLPESCLGEHEVPVPSYYRASPSYSALDKTPHCSGANDFEAPFEQRASLNPRAEHLESPQLGGK 195
                :.|.|           .....|.:...|...|.|.                   ||.:||.
  Fly   427 ----DMCRG-----------GGGGGSGVGNGPVGVGGNG-------------------SPGIGGV 457

Human   196 VSFPETPKSDSQTPSPNEIKTEQSLAGPKGSPSESEKERAKAADSSPD-----TSDNEAKEEIKA 255
            :|                  .:.||.        .....|.|..:.|:     ............
  Fly   458 LS------------------VQNSLI--------MANSAAAAGSAHPNGMGVGLGSGSGLSSCSL 496

Human   256 ENTTGNWLTAKSGRKKRCPYTKHQTLELEKEFLFNMYLTRERRLEISKTINLTDRQVKIWFQNRR 320
            .:.|.|     |||..   :|..|..||||||.||.||||.||:||:.|:.|.:.||||||||||
  Fly   497 SSNTNN-----SGRTN---FTNKQLTELEKEFHFNRYLTRARRIEIANTLQLNETQVKIWFQNRR 553

Human   321 MKLKKMNRENRI 332
            ||.||..:|..|
  Fly   554 MKQKKRVKEGLI 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXC10	NP_059105.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29		6/27 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	187..271		15/88 (17%)
		Homeodomain	269..325	CDD:459649	33/55 (60%)
lab	NP_476613.1	Homeodomain	505..558	CDD:459649	33/55 (60%)