DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43313 and CHPF

DIOPT Version :9

Sequence 1:	NP_001285184.1	Gene:	CG43313 / 32259	FlyBaseID:	FBgn0263005	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_078812.3	Gene:	CHPF / 79586	HGNCID:	24291	Length:	775	Species:	Homo sapiens

Alignment Length:	878	Identity:	240/878 - (27%)
Similarity:	383/878 - (43%)	Gaps:	204/878 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IGLLLGLLLSWHIPEDIW-EEEC---PEEAAENLLIER--------------------------F 50
            :|:.||..||  :....| ||.|   |.:..::.|..|                          .
Human    18 VGISLGFTLS--LLSVTWVEEPCGPGPPQPGDSELPPRGNTNAARRPNSVQPGAEREKPGAGEGA 80

  Fly    51 GQEFEPHLNLINKPLAAKKPVKNVIRPRYYSSELGIREKLFIGVMTSQEHINTFATAFNRTTAHL 115
            |:.:||.: |...|....:..|..:|.||.|:|||||::|.:.|:|||..:.|...|.|||..|
Human    81 GENWEPRV-LPYHPAQPGQAAKKAVRTRYISTELGIRQRLLVAVLTSQTTLPTLGVAVNRTLGH- 143

  Fly   116 VNKIKFFIYADSVKTNYKLKNIVGFTDTRESRRP----------------FHV-VKYIADNYLDE 163
                             :|:.:|..|..|..|.|                .|: ::::.:.:.|:
Human   144 -----------------RLERVVFLTGARGRRAPPGMAVVTLGEERPIGHLHLALRHLLEQHGDD 191

  Fly   164 YDYFLLVPDTVYVDARKLVKLLYHMSI--TFDLYMGGARIGLDPSGGGASADGQSNEPPANEEEA 226
            :|:|.|||||.|.:|..|.:|..|:|:  ...||:|..:   |..||               |..
Human   192 FDWFFLVPDTTYTEAHGLARLTGHLSLASAAHLYLGRPQ---DFIGG---------------EPT 238

  Fly   227 PGASDRNYCSLEAGILLSSSVIRKMRNNLERCVR--IGSTSDHSVNIGRCVKYASRVAGCQESFQ 289
            ||    .||....|:|||..:::::|.:||.|..  :.:..|..  :|||:..|:.| ||....:
Human   239 PG----RYCHGGFGVLLSRMLLQQLRPHLEGCRNDIVSARPDEW--LGRCILDATGV-GCTGDHE 296

  Fly   290 GMRQFSYALDAPGRRHREFSELAKEEAFRNASTVYPVQTPEDFYRLHAYYSKHHLEK----VQER 350
            |: .:|:...:||...:|     .:..||:|.|.:||:.|...|:||..:::..||:    :||.
Human   297 GV-HYSHLELSPGEPVQE-----GDPHFRSALTAHPVRDPVHMYQLHKAFARAELERTYQEIQEL 355

  Fly   351 GYALEQKSYRIANGSISNKILEIRWPLGVPPPSAPETRHDILTWQLLNGTHNF-LPNGNAEHAVA 414
            .:.::..|:...:|..:     ..||:|:|.||.|.:|.::|.|......|.| ..:|:..   .
Human   356 QWEIQNTSHLAVDGDQA-----AAWPVGIPAPSRPASRFEVLRWDYFTEQHAFSCADGSPR---C 412

  Fly   415 TLSRIEAQDFAKVLEIALQYAALK-HP--RLSYHSLHSAYRKFDATRGMDYQLHLNLQ----EGS 472
            .|...:..|.|.||..||:....: ||  ||....|.:.||:||..|||:|.|.|.|:    :|
Human   413 PLRGADRADVADVLGTALEELNRRYHPALRLQKQQLVNGYRRFDPARGMEYTLDLQLEALTPQG- 476

  Fly   473 GRSRRLVIKSFEVVKPLGRVEVVPSPYVTESTRIAMLVPAFEHQVPDALLFVEQYERICMQNQD- 536
              .||.:.:..::::||.|||::|.|||||::|:.:|:|....:...|..|:|.:....::..|
Human   477 --GRRPLTRRVQLLRPLSRVEILPVPYVTEASRLTVLLPLAAAERDLAPGFLEAFATAALEPGDA 539

  Fly   537 NTFLLLIFMYRLESPSK-GDEDPFKALKTLALDLSSKYKTDGSRIAWVSIRLPEQLSEPVDPQSW 600
            ...|.|:.:|......: ...|.|..:|....:|..::  .|:|:.|:|:    |.:.|
Human   540 AAALTLLLLYEPRQAQRVAHADVFAPVKAHVAELERRF--PGARVPWLSV----QTAAP------ 592

  Fly   601 LLHASMYGPRQLLSLVVADLALPKLGLESLVLLATPGMVFKADFLNRVRMNTIQGFQVYAPIGFQ 665
                   .|.:|:     ||...|..|::|.|||.|..|...|||||.||:.|.|:|.:.|:.||
Human   593 -------SPLRLM-----DLLSKKHPLDTLFLLAGPDTVLTPDFLNRCRMHAISGWQAFFPMHFQ 645

  Fly   666 MY------------PCRWAHFCRECDTCDVSQSSGYFDRHNHDVIAFYSRDYVQARKLLHPQGLP 718
            .:            |             ::.:.:|.|||.......||:.|||.||.
Human   646 AFHPAVAPPQGPGPP-------------ELGRDTGRFDRQAASEACFYNSDYVAARG-------- 689

  Fly   719 IIRSDLDIDQLLLQPGEETRPPGVESILDMFVAAQH--SVHILRGVEPNLRFGQDVRNHLARGGT 781
                       .|....|.....:|| ||::....|  |:|:||.|||.|......:...||
Human   690 -----------RLAAASEQEEELLES-LDVYELFLHFSSLHVLRAVEPALLQRYRAQTCSAR--- 739

  Fly   782 LPQSVPERCGREQCIHLASRKQIGDAIIRYEDK 814
            |.:.:..||.:.....|.||.|:  |::.:|.:
Human   740 LSEDLYHRCLQSVLEGLGSRTQL--AMLLFEQE 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43313	NP_001285184.1	CHGN	254..804	CDD:283361	162/579 (28%)
CHPF	NP_078812.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	37..100		9/63 (14%)
		Galactosyl_T	<194..304	CDD:328824	41/135 (30%)
		CHGN	262..762	CDD:310350	162/579 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159183
Domainoid	1	1.000	173	1.000	Domainoid score	I3700
eggNOG	1	0.900	-	-		E1_KOG3708
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11574
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3222
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49343
OrthoDB	1	1.010	-	-		D331164at33208
OrthoFinder	1	1.000	-	-		FOG0003088
OrthoInspector	1	1.000	-	-		otm42248
orthoMCL	1	0.900	-	-		OOG6_106235
Panther	1	1.100	-	-	O	PTHR12369
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5739
SonicParanoid	1	1.000	-	-		X2057
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800