DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43313 and CHPF2

DIOPT Version :9

Sequence 1:	NP_001285184.1	Gene:	CG43313 / 32259	FlyBaseID:	FBgn0263005	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_061888.1	Gene:	CHPF2 / 54480	HGNCID:	29270	Length:	772	Species:	Homo sapiens

Alignment Length:	863	Identity:	236/863 - (27%)
Similarity:	376/863 - (43%)	Gaps:	177/863 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 VIGLLLG-----LLLSWHIPEDIWEEECPEEAAE---------NLLIERFGQEFEPHL-NLINKP 64
            ::||.||     |.:||...|.  |:.|.|...|         ...:::..::|:|.: .....|
Human    17 ILGLSLGCSLSLLRVSWIQGEG--EDPCVEAVGERGGPQNPDSRARLDQSDEDFKPRIVPYYRDP 79

  Fly    65 LAAKKPVKNVIRPRYYSSELGIREKLFIGVMTSQEHINTFATAFNRTTAHLVNKIKFFIYADSVK 129
               .||.|.|:|.||..:|||.||:|.:.|:||:..::|.|.|.|||.||...::.:|......:
Human    80 ---NKPYKKVLRTRYIQTELGSRERLLVAVLTSRATLSTLAVAVNRTVAHHFPRLLYFTGQRGAR 141

  Fly   130 TNYKLKNIVGFTDTRESRRPFHVVKYIADNYLDEYDYFLLVPDTVYVDARKLVKLLYHMSITFDL 194
            ....:: :|...|.|.:......::::..::..:||:|.::.|..||.|.:|..|..|:||..||
Human   142 APAGMQ-VVSHGDERPAWLMSETLRHLHTHFGADYDWFFIMQDDTYVQAPRLAALAGHLSINQDL 205

  Fly   195 YMGGARIGLDPSGGGASADGQSNEPPANEEEAPGASDR-NYCSLEAGILLSSSVIRKMRNNLERC 258
            |:|.|                        ||..||.:: .||....|.|||.|::.::|.:|:.|
Human   206 YLGRA------------------------EEFIGAGEQARYCHGGFGYLLSRSLLLRLRPHLDGC 246

  Fly   259 VRIGSTSDHSVNIGRCVKYASRVAGCQESFQGMRQFSYALDAPGRRHREFSELAK--------EE 315
            .....::.....:|||: ..|...||....|            |:::|.| ||||        ..
Human   247 RGDILSARPDEWLGRCL-IDSLGVGCVSQHQ------------GQQYRSF-ELAKNRDPEKEGSS 297

  Fly   316 AFRNASTVYPVQTPEDFYRLHAYYSKHHLEKVQERGYA-LEQKSYRIANGSISNKILE--IRWPL 377
            ||.:|..|:||......||||..:|...|    ||.|: :||...:|.|.::.....|  :.||:
Human   298 AFLSAFAVHPVSEGTLMYRLHKRFSALEL----ERAYSEIEQLQAQIRNLTVLTPEGEAGLSWPV 358

  Fly   378 GVPPPSAPETRHDILTWQLLNGTHNF-LPNGNAEHAVATLSRIEAQDFAKVLEIALQYAALKH-P 440
            |:|.|..|.:|.::|.|......|.| ..:|..:..:...||.:..|   .||.||:....:: |
Human   359 GLPAPFTPHSRFEVLGWDYFTEQHTFSCADGAPKCPLQGASRADVGD---ALETALEQLNRRYQP 420

  Fly   441 RLSYHS--LHSAYRKFDATRGMDYQLHLNLQEGSGRS-RRLVIKSFEVVKPLGRVEVVPSPYVTE 502
            ||.:..  |.:.||:||..|||:|.|.|.|:..:.|. ||.:.:...:::||.|||::|.|||||
Human   421 RLRFQKQRLLNGYRRFDPARGMEYTLDLLLECVTQRGHRRALARRVSLLRPLSRVEILPMPYVTE 485

  Fly   503 STRIAMLVPAFEHQVPDALLFVEQYERICMQNQDNTFLLLIFMYRLESPSKGDEDPFKALKTLAL 567
            :||:.:::|....:...|..|:|.:....::.:::..|.|:.:|......:|..|||..:|..|.
Human   486 ATRVQLVLPLLVAEAAAAPAFLEAFAANVLEPREHALLTLLLVYGPREGGRGAPDPFLGVKAAAA 550

  Fly   568 DLSSKYKTDGSRIAWVSIR--LPEQLSEPVDPQSWLLHASMYGPRQLLSLVVADLALPKLGLESL 630
            :|..:|  .|:|:||:::|  .|.|:.                        :.|:...|..:::|
Human   551 ELERRY--PGTRLAWLAVRAEAPSQVR------------------------LMDVVSKKHPVDTL 589

  Fly   631 VLLAT----PGMVFKADFLNRVRMNTIQGFQVYAPIGFQMY------------------------ 667
            ..|.|    ||    .:.|||.|||.|.|:|.:.|:.||.:
Human   590 FFLTTVWTRPG----PEVLNRCRMNAISGWQAFFPVHFQEFNPALSPQRSPPGPPGAGPDPPSPP 650

  Fly   668 ---PCRWAHFCRECDTCDVSQSSGYFDRHNHDVIAFYSRDYVQARKLLHPQGLPIIRSDLDIDQL 729
               |.|.|..            .|.|||.......||:.||:.||..|..:
Human   651 GADPSRGAPI------------GGRFDRQASAEGCFYNADYLAARARLAGE-------------- 689

  Fly   730 LLQPGEETRPPGVESILDMFVAAQHSVHILRGVEPNLRFGQDVRNHLARGGTLPQSVPERCGREQ 794
            |....||....|:| ::|:|:... .:|:.|.|||.|.....:|:...|   |.:.:..||....
Human   690 LAGQEEEEALEGLE-VMDVFLRFS-GLHLFRAVEPGLVQKFSLRDCSPR---LSEELYHRCRLSN 749

  Fly   795 CIHLASRKQIGDAIIRYE 812
            ...|..|.|:..|:...|
Human   750 LEGLGGRAQLAMALFEQE 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43313	NP_001285184.1	CHGN	254..804	CDD:283361	161/598 (27%)
CHPF2	NP_061888.1	Galactosyl_T	<177..>269	CDD:304462	33/116 (28%)
		CHGN	242..759	CDD:283361	161/598 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	629..662		3/44 (7%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159184
Domainoid	1	1.000	173	1.000	Domainoid score	I3700
eggNOG	1	0.900	-	-		E1_KOG3708
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3222
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49343
OrthoDB	1	1.010	-	-		D331164at33208
OrthoFinder	1	1.000	-	-		FOG0003088
OrthoInspector	1	1.000	-	-		otm42248
orthoMCL	1	0.900	-	-		OOG6_106235
Panther	1	1.100	-	-	LDO	PTHR12369
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5739
SonicParanoid	1	1.000	-	-		X2057
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800