DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43313 and Chpf2

DIOPT Version :9

Sequence 1:	NP_001285184.1	Gene:	CG43313 / 32259	FlyBaseID:	FBgn0263005	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001100044.1	Gene:	Chpf2 / 296733	RGDID:	1306404	Length:	770	Species:	Rattus norvegicus

Alignment Length:	875	Identity:	235/875 - (26%)
Similarity:	384/875 - (43%)	Gaps:	185/875 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RPFTALNRNHYFVIGLLLG-----LLLSWHIPEDIWEEECPEEAAE-------NLL--IERFGQE 53
            ||...|      ::||.||     |.:||...|.  |:.|.|...:       :|.  :::..::
  Rat    11 RPMLPL------ILGLSLGCSLSLLRVSWIQGEG--EDPCVEAVGKPGGPQNPDLKHGLDQSDED 67

  Fly    54 FEPHL-NLINKPLAAKKPVKNVIRPRYYSSELGIREKLFIGVMTSQEHINTFATAFNRTTAHLVN 117
            |:|.: .....|   .|..|.|:|.||..:|||.||:|.:.|:||:..::|.|.|.|||.||...
  Rat    68 FKPRIVPYYRDP---NKHYKKVLRTRYIQTELGSRERLLVAVLTSRATLSTLAVAVNRTVAHHFP 129

  Fly   118 KIKFFIYADSVKTNYKLKNIVGFTDTRESRRPFHVVKYIADNYLDEYDYFLLVPDTVYVDARKLV 182
            ::.:|......:....:: :|...|.|.:......::::..::..:||:|.::.|..||.|.:|.
  Rat   130 RLLYFTGQRGARAPAGMQ-VVSHGDERPAWLMSETLRHLHTHFGADYDWFFIMQDDTYVQAPRLA 193

  Fly   183 KLLYHMSITFDLYMGGARIGLDPSGGGASADGQSNEPPANEEEAPGASDR-NYCSLEAGILLSSS 246
            .|..|:||..|||:|.|                        ||..|..:: .||....|.|||.|
  Rat   194 ALAGHLSINQDLYLGHA------------------------EEFIGTGEQARYCHGGFGYLLSRS 234

  Fly   247 VIRKMRNNLERCVRIGSTSDHSVNIGRCVKYASRVAGCQESFQGMRQFSYALDAPGRRHREFSEL 311
            ::.::|.:|:.|.....::.....:|||:.....: ||....|            |:::|.| ||
  Rat   235 LLLRLRPHLDGCRGDILSARPDEWLGRCLIDTLGI-GCVSQHQ------------GQQYRSF-EL 285

  Fly   312 AKEE--------AFRNASTVYPVQTPEDFYRLHAYYSKHHLEKVQERGYALEQKSYRIANGSISN 368
            ||..        ||.:|.||:||......||||..:|...||:..:.   :||...:|.|.::..
  Rat   286 AKNRDPEKEGSPAFLSAFTVHPVSEGTLMYRLHKRFSALELERAYKE---IEQLQAQIRNLTVLT 347

  Fly   369 KILE--IRWPLGVPPPSAPETRHDILTWQLLNGTHNF-LPNGNAEHAVATLSRIEAQDFAKVLEI 430
            ...|  :.||:|:|.|..|.:|.::|.|......|.| ..:|..:..:...||.:..|   .::.
  Rat   348 PEGEAGLSWPVGLPAPFIPHSRFEVLGWDYFTEQHTFACADGAPKCPLQGASRADVGD---AVDT 409

  Fly   431 ALQYAALKH-PRLSYHS--LHSAYRKFDATRGMDYQLHLNLQEGSGRS-RRLVIKSFEVVKPLGR 491
            ||:....:: |||.:..  |.:.||:||..|||:|.|.|.|:..:.|. ||.:.:...:::||.:
  Rat   410 ALEQLNRRYQPRLRFQKQRLLNGYRRFDPARGMEYTLDLLLEAVTQRGHRRSLARRVSLLRPLSK 474

  Fly   492 VEVVPSPYVTESTRIAMLVPAFEHQVPDALLFVEQYERICMQNQDNTFLLLIFMYRLESP--SKG 554
            ||::|.|||||:||:.:::|....:.|.||.|:|.:....::.:::..|.|:.:|   .|  .:|
  Rat   475 VEILPMPYVTEATRVQLVLPILVAEAPAALAFLEAFAASVLEPREHALLTLLLVY---GPREGRG 536

  Fly   555 DEDPFKALKTLALDLSSKYKTDGSRIAWVSIR--LPEQLSEPVDPQSWLLHASMYGPRQLLSLVV 617
            ..|||..:|..|.:|..:|  .|:|:||:::|  .|.|:.                        :
  Rat   537 GPDPFLGVKAAAAELERRY--PGTRLAWLAVRAEAPSQVR------------------------L 575

  Fly   618 ADLALPKLGLESLVLLAT----PGMVFKADFLNRVRMNTIQGFQVYAPIGFQMY----------- 667
            .|:...|..:::|..|.|    ||    ::.|||.|||.|.|:|.:.|:.||.:
  Rat   576 MDVISKKHPVDTLFFLTTVWTRPG----SEVLNRCRMNAISGWQAFFPVHFQEFNPVLSPQRSPP 636

  Fly   668 ---------------PCRWAHFCRECDTCDVSQSSGYFDRHNHDVIAFYSRDYVQARKLLHPQGL 717
                           |.|.|            ...|.|||.......||:.||:.||..|..:
  Rat   637 GVPGAGPDPPSPGVDPSRGA------------PVGGRFDRQASAEGCFYNADYLAARARLAGE-- 687

  Fly   718 PIIRSDLDIDQLLLQPGEETRPPGVESILDMFVAAQHSVHILRGVEPNLRFGQDVRNHLARGGTL 782
                        |....||....|:| ::|:|:... .:|:.|.|||.|.....:|:...|   |
  Rat   688 ------------LAGQEEEEALEGLE-VMDVFLRFS-GLHLFRAVEPGLVQKFSLRDCSPR---L 735

  Fly   783 PQSVPERCGREQCIHLASRKQIGDAIIRYE 812
            .:.:..||.......|.:|.|:..|:...|
  Rat   736 SEELYHRCRLSNLEGLGARTQLAMALFEQE 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43313	NP_001285184.1	CHGN	254..804	CDD:283361	159/598 (27%)
Chpf2	NP_001100044.1	Galactosyl_T	<177..>269	CDD:419759	31/115 (27%)
Chpf2	NP_001100044.1	CHGN	242..757	CDD:399001	159/598 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353198
Domainoid	1	1.000	180	1.000	Domainoid score	I3412
eggNOG	1	0.900	-	-		E1_KOG3708
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	257	1.000	Inparanoid score	I3073
OMA	1	1.010	-	-		QHG49343
OrthoDB	1	1.010	-	-		D331164at33208
OrthoFinder	1	1.000	-	-		FOG0003088
OrthoInspector	1	1.000	-	-		otm46403
orthoMCL	1	0.900	-	-		OOG6_106235
Panther	1	1.100	-	-	LDO	PTHR12369
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2057
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.770