DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43313 and mig-22

DIOPT Version :9

Sequence 1:	NP_001285184.1	Gene:	CG43313 / 32259	FlyBaseID:	FBgn0263005	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_498934.1	Gene:	mig-22 / 176231	WormBaseID:	WBGene00003253	Length:	804	Species:	Caenorhabditis elegans

Alignment Length:	857	Identity:	194/857 - (22%)
Similarity:	323/857 - (37%)	Gaps:	201/857 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FVIGLLLGLLLSWHIPE-DIWEE-----ECPEEAAENLLIE-------RFGQEFEPHLNLINKPL 65
            |:||..|.|......|. |:...     .|..:..|..::|       |..::...|..:....:
Worm    15 FLIGAALALFFFSSTPSIDLTSSLAAFTSCQNQETETNVLEPSALEKGRVYKDLSEHWIVHQDDM 79

  Fly    66 AAKKPVKN------VIRPRYYSSELGIREKLFIGVMTSQEHINTFATAFNRTTAHLVNKIKFFIY 124
            .|  |..|      |.|.|:.::|||.||::...||..    :..|.:.|.|....|.::..|
Worm    80 PA--PPHNQDATPKVTRTRFAATELGTRERVMAAVMAE----SALALSINATLGRHVPRVHLF-- 136

  Fly   125 ADSVKTNYKLKNIVGFTDTRESRRPFH-VVKYIADNYL--DEYDYFLLVPDTVYVDARKLVKLLY 186
            |||.:.:..|..:...:..:.:.:..| :|..:..|..  :.||:|||..|:.|::...|::::.
Worm   137 ADSSRIDNDLAQLTNLSPYKLNGQKTHSMVLGLLFNMTVHNNYDWFLLAKDSTYINPFVLLRMID 201

  Fly   187 HMSITFDLYMGGARIGLDPSGGGASADGQSNEPPANEEEAPGASDRNYCSLEAGILLSSSVIRKM 251
            .|:                          .|||....|.|...|.|  |.|:.|:|||...:..:
Worm   202 TMN--------------------------WNEPVVMGEAAEDGSGR--CRLDTGMLLSQPAMHAL 238

  Fly   252 RNNLERCVRIG-STSDHSVNIGRCVKYASRVAGCQESFQGMR----QFSYALDAPGRRHREFSEL 311
            .||...|.... :..|..:...:|::.|:.:. |:...||:|    :.:...|:|. .|....:.
Worm   239 MNNRNACNNFALAADDDQLAFEKCIQIATNLT-CKPLHQGVRYEVWRGAERADSPA-AHDSIEDW 301

  Fly   312 AKEEAFRNASTVYPVQTPEDFYRLHAYYSKHHLEKVQERGYALEQKSYRIANGSISNKILEIRWP 376
            ....||:.|..|..:.:..|...||.|:.:..:::.......:|.:..|:|..........|.||
Worm   302 KHSPAFKRALAVPRLLSDADASALHDYFVRVEMQRADREIIKMEAELSRLAEQEARETGEAISWP 366

  Fly   377 LGVPPPSAPETRHDILTWQLLNGTHNFL--PNGNAEHAVATLSRIEAQDFAKVLEI---ALQYAA 436
            ..:||.:.|..|:.:.||:....|..|.  ||.|       :.|:|.:||..|.|:   |.|...
Worm   367 PALPPYAKPPNRYQVSTWEYFTMTELFRSEPNQN-------VRRLEGKDFDDVAEVVVAARQQVE 424

  Fly   437 LKHPRLSYHSLHSAYRKFDATRGMDYQLHL-------------NLQEGSGRS------RRLVI-K 481
            .:.|.|.:..|.:.||.||..|||||.:.|             |..|....:      :.:|: :
Worm   425 SEEPELEFVQLRNGYRVFDPRRGMDYMVDLTYRKTVNEMPEVDNRFESDNEAAHEESLKEIVVER 489

  Fly   482 SFEVVKPLGRVEVV-PSPYVTESTRIAMLVP-AFEHQVPDALLFVEQYERICM---QNQDNTFLL 541
            ...|.:.:...::: .:|||.|.|.:.:::| |.|..|..|...:.:..|:|:   :....|.::
Worm   490 RVHVSRMIASTQLMNQAPYVKEDTDVTVVIPVASEKDVLPARKLLARQARLCLFPTEEARKTRMV 554

  Fly   542 LIFMYRLESPS----KGDEDPFK------ALKTLALDLSSKYKTDGSRIAWVSIRLPEQLSEPVD 596
            :.....:||.|    ..|.:..|      .|:|..|.:.....|:|...|
Worm   555 VAVFPLIESRSVTAITNDMEELKRRCKRSLLETDVLPVHPAVSTEGKGTA--------------- 604

  Fly   597 PQSWLLHASMYGPRQLLSLVVADLALPKLGLESLVLLATPGMVFKADFLNRVRMNTIQGFQVYAP 661
                             :....|.|:.:.|..::.||.:|....:.:|.:|.|:|||:.:||:.|
Worm   605 -----------------AAAALDDAVDRYGANTIYLLLSPHADVQKEFFDRARINTIKHYQVFFP 652

  Fly   662 IGFQMY--------------------PCRWAHFCRECD--------TCDVSQSSGYFDRHNHDVI 698
            :.|..|                    ..|.|...|..|        |..|.:..|.||..:....
Worm   653 VPFVEYHPTISGMEMTEKEEKETPTEQAREAALSRLRDGVEPKRKRTLIVQKEHGRFDSQDFSCF 717

  Fly   699 AFYSRDYVQARKLLHPQGLPIIRSDLDIDQLLLQPGEETRPPGVESILDMFVAAQHSVHILRGVE 763
            |.|..|||.||...                     |:..|.   ..::..|: .|.|:|:||.||
Worm   718 AVYGVDYVTARAKF---------------------GQNERR---NDLISAFL-GQDSIHVLRAVE 757

  Fly   764 PNLRFGQDVRNH 775
            |.||    :|.|
Worm   758 PTLR----IRYH 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43313	NP_001285184.1	CHGN	254..804	CDD:283361	134/595 (23%)
mig-22	NP_498934.1	CHGN	241..796	CDD:283361	134/595 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166753
Domainoid	1	1.000	106	1.000	Domainoid score	I4158
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11574
Inparanoid	1	1.050	144	1.000	Inparanoid score	I3031
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49343
OrthoDB	1	1.010	-	-		D331164at33208
OrthoFinder	1	1.000	-	-		FOG0003088
OrthoInspector	1	1.000	-	-		oto19796
orthoMCL	1	0.900	-	-		OOG6_106235
Panther	1	1.100	-	-	LDO	PTHR12369
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5739
SonicParanoid	1	1.000	-	-		X2057
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.940