DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43313 and Chpf2

DIOPT Version :9

Sequence 1:	NP_001285184.1	Gene:	CG43313 / 32259	FlyBaseID:	FBgn0263005	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_598674.2	Gene:	Chpf2 / 100910	MGIID:	1917522	Length:	768	Species:	Mus musculus

Alignment Length:	854	Identity:	237/854 - (27%)
Similarity:	387/854 - (45%)	Gaps:	145/854 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RPFTALNRNHYFVIGLLLG-----LLLSWHIPEDIWEEEC---------PEEAAENLLIERFGQE 53
            ||...|      ::||.||     |.:||...|.  |:.|         |:.......:::..::
Mouse    11 RPVLPL------ILGLSLGCSLSLLRVSWIQGEG--EDPCVEAVGKPGGPQNPDSKNGLDQGDED 67

  Fly    54 FEPHL-NLINKPLAAKKPVKNVIRPRYYSSELGIREKLFIGVMTSQEHINTFATAFNRTTAHLVN 117
            |.|.: .....|   .||.|.|:|.||..:|||.||:|.:.|:||:..::|.|.|.|||.||...
Mouse    68 FRPRIVPYYRDP---NKPYKKVLRTRYIQTELGSRERLLVAVLTSRATLSTLAVAVNRTVAHHFP 129

  Fly   118 KIKFFIYADSVKTNYKLKNIVGFTDTRESRRPFHVVKYIADNYLDEYDYFLLVPDTVYVDARKLV 182
            ::.:|......:....:: :|...|.|.:......::::..::..:||:|.::.|..||.|.:|.
Mouse   130 RLLYFTGQRGARAPAGMQ-VVSHGDERPAWLMSETLRHLHTHFGADYDWFFIMQDDTYVQAPRLA 193

  Fly   183 KLLYHMSITFDLYMGGARIGLDPSGGGASADGQSNEPPANEEEAPGASDR-NYCSLEAGILLSSS 246
            .|..|:||..|||:|.|                        ||..|..:: .||....|.|||.|
Mouse   194 ALAGHLSINQDLYLGHA------------------------EEFIGTGEQARYCHGGFGYLLSRS 234

  Fly   247 VIRKMRNNLERCVRIGSTSDHSVNIGRCVKYASRVAGCQESFQGMRQFSYALDAPGRRHREFSEL 311
            ::.::|.:|:.|.....::.....:|||:.....: ||....||.:..|:.|    .::|: .|.
Mouse   235 LLLRLRPHLDGCRGDILSARPDEWLGRCLIDTLGI-GCVSQHQGQQYRSFEL----AKNRD-PEK 293

  Fly   312 AKEEAFRNASTVYPVQTPEDFYRLHAYYSKHHLEKVQERGYA-LEQKSYRIANGSISNKILE--I 373
            .:..||.:|..|:||......||||..:|...|    ||.|: :||...:|.|.::.....|  :
Mouse   294 EESPAFLSAFAVHPVPEGTLMYRLHKRFSALEL----ERAYSEIEQLQAQIRNLTVLTPEGEAGL 354

  Fly   374 RWPLGVPPPSAPETRHDILTWQLLNGTHNF-LPNGNAEHAVATLSRIEAQDFAKVLEIALQYAAL 437
            .||:|:|.|..|.:|.::|.|......|.| ..:|..:..:...||.:..|   .::.||:....
Mouse   355 SWPVGLPAPFTPHSRFEVLGWDYFTEQHTFACADGAPKCPLQGASRADVGD---AVDTALEQLNR 416

  Fly   438 KH-PRLSYHS--LHSAYRKFDATRGMDYQLHLNLQEGSGRS-RRLVIKSFEVVKPLGRVEVVPSP 498
            :: |||.:..  |.:.||:||..|||:|.|.|.|:..:.|. ||.:.:...:::||.|||::|.|
Mouse   417 RYQPRLRFRKQRLLNGYRRFDPARGMEYTLDLLLEAVTQRGHRRSLARRVSLLRPLSRVEILPMP 481

  Fly   499 YVTESTRIAMLVPAFEHQVPDALLFVEQYERICMQNQDNTFLLLIFMYRLESP--SKGDEDPFKA 561
            ||||:||:.:::|....:.|.||.|:|.:....::.:::..|.|:.:|   .|  .:|..|||..
Mouse   482 YVTEATRVQLVLPLLVAEAPAALAFLEAFAASVLEPREHALLTLLLVY---GPREGRGGPDPFLG 543

  Fly   562 LKTLALDLSSKYKTDGSRIAWVSIR--LPEQLSEPVDPQSWLLHASMYGPRQLLSLVVADLALPK 624
            :|..|.:|..:|  .|:|:||:::|  .|.|:.                        :.|:...|
Mouse   544 VKAAAAELERRY--PGARLAWLAVRAEAPSQVR------------------------LMDVISKK 582

  Fly   625 LGLESLVLLAT----PGMVFKADFLNRVRMNTIQGFQVYAPIGFQMY-----PCRWAHFCRECDT 680
            ..:::|..|.|    ||    ::.|||.|||.|.|:|.:.|:.||.:     |.|........|.
Mouse   583 HPVDTLFFLTTVWTRPG----SEVLNRCRMNAISGWQAFFPVHFQEFNPALSPQRSPPGVPGADP 643

  Fly   681 ----CDVSQSS---GYFDRHNHDVIAFYSRDYVQARKLLHPQGLPIIRSDLDIDQLLLQPGEETR 738
                .|.|:.:   |.|||.......||:.||:.||..|..:              |....||..
Mouse   644 PSPGVDPSRGAPVGGRFDRQASAEGCFYNADYLAARARLAGE--------------LAGQEEEEA 694

  Fly   739 PPGVESILDMFVAAQHSVHILRGVEPNLRFGQDVRNHLARGGTLPQSVPERCGREQCIHLASRKQ 803
            ..|:| ::|:|:... .:|:.|.|||.|.....:|:...|   |.:.:..||.......|.:|.|
Mouse   695 LEGLE-VMDVFLRFS-GLHLFRAVEPGLVQKFSLRDCSPR---LSEELYHRCRLSNLEGLGARTQ 754

  Fly   804 IGDAIIRYE 812
            :..|:...|
Mouse   755 LAMALFEQE 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43313	NP_001285184.1	CHGN	254..804	CDD:283361	161/577 (28%)
Chpf2	NP_598674.2	Galactosyl_T	<177..>269	CDD:419759	31/115 (27%)
Chpf2	NP_598674.2	CHGN	242..755	CDD:399001	161/577 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849552
Domainoid	1	1.000	173	1.000	Domainoid score	I3680
eggNOG	1	0.900	-	-		E1_KOG3708
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3194
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49343
OrthoDB	1	1.010	-	-		D331164at33208
OrthoFinder	1	1.000	-	-		FOG0003088
OrthoInspector	1	1.000	-	-		otm44301
orthoMCL	1	0.900	-	-		OOG6_106235
Panther	1	1.100	-	-	LDO	PTHR12369
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5739
SonicParanoid	1	1.000	-	-		X2057
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800