DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43313 and chpf2

DIOPT Version :9

Sequence 1:	NP_001285184.1	Gene:	CG43313 / 32259	FlyBaseID:	FBgn0263005	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	XP_001337205.1	Gene:	chpf2 / 100000654	ZFINID:	ZDB-GENE-030131-7797	Length:	764	Species:	Danio rerio

Alignment Length:	857	Identity:	233/857 - (27%)
Similarity:	375/857 - (43%)	Gaps:	173/857 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 VIGLLLG-----LLLSWHIPEDIWEEECPEEAAENLLIE-------RFGQE------FEPHLNLI 61
            ::||.||     |::||  .:...:|.|.::.....|:.       ..|||      |:|.:...
Zfish    17 ILGLSLGCSLSLLMVSW--TQGDTDEACGDDLGNGRLVHNGHIRDLHNGQEGDGNEDFQPRIVPY 79

  Fly    62 NKPLAAKKPVKNVIRPRYYSSELGIREKLFIGVMTSQEHINTFATAFNRTTAHLVNKIKFFIYAD 126
            :|.  ..||.|.|:|.||..:||||||:|.:|:::|:..:||...|.|:|.||..::..||....
Zfish    80 HKD--PNKPHKKVLRTRYIHTELGIRERLLVGILSSRATLNTLGVAVNKTVAHHFHRTFFFTGLR 142

  Fly   127 SVKTNYKLKNIVGFTDTRESRRPFHVVKYIADNYLDEYDYFLLVPDTVYVDARKLVKLLYHMSIT 191
            |.|..:.:. ::...|.|.....:..::::..::.:|||:|.|..|..|..|.::::|:.|:|..
Zfish   143 SAKAPHGMA-VIAHGDDRPVWLMYETIRHLHQHHANEYDWFYLAQDDTYTQAERIMELVNHLSAG 206

  Fly   192 FDLYMGGARIGLDPSGGGASADGQSNEPPANEEEAPGASDR-NYCSLEAGILLSSSVIRKMRNNL 255
            .|:|||.|                        ||..|..:| .||....|.|||.|::.:::.:|
Zfish   207 QDMYMGRA------------------------EEFIGGEERARYCHGGYGYLLSRSLLARLQPHL 247

  Fly   256 ERCVRIGSTSDHSVN----IGRC-VKYASRVAGCQESFQGMRQFSYALDAPGRRHREFSELAKEE 315
            :.|    .....||.    :||| :.|..  ..|.|..|.|....:.|.......||.|     .
Zfish   248 DSC----RNDILSVRPDEWLGRCIIDYLG--LSCVEKHQEMTYRYFELQKNVDPEREDS-----A 301

  Fly   316 AFRNASTVYPVQTPEDFYRLHAYYSKHHLEKVQERGYALEQKSYRIANGSISNKILEIRWPLGVP 380
            .|:||.||:|:..|...||||..|::..|:....:...|:.:...|:..:...| ....||:|:.
Zfish   302 QFKNAFTVHPISEPALMYRLHKRYNQIELDWTYAQIQHLQNQINNISELTPEGK-AGATWPIGIN 365

  Fly   381 PPSAPETRHDILTWQLLNGTHNFLPNGNAEHAVATLSRIEAQDFAKVLEIAL-----QYAALKHP 440
            ||..|:||.:::.|:.....|.:....::..  ..|...:..|.:.|||.|:     :|    .|
Zfish   366 PPFRPKTRFEVINWEYFTEEHIYSCGDSSPK--CELRGADRADVSSVLETAVGRLNERY----QP 424

  Fly   441 RLSYHS--LHSAYRKFDATRGMDYQLHLNLQEGSGRSRRLVI-KSFEVVKPLGRVEVVPSPYVTE 502
            :|.:..  |.:.||:||.||||:|.|.|.|:..:.:....|| |...::|||..||::|.|||||
Zfish   425 QLRFRKRRLLNGYRRFDPTRGMEYVLDLALEAFTQKGHSQVIAKRVNLLKPLSAVEIIPMPYVTE 489

  Fly   503 STRIAMLVPAFEHQVPDALLFVEQYERICMQNQDNTFLLLIFMY-RLESPSKGDEDPFKALKTLA 566
            :||:.:::|...|.......|::.|....:...||..|..:|:| ..::......|.|..:|.:.
Zfish   490 ATRVQVILPVTAHDQDFVGNFLDMYVMNALDTHDNALLTFLFVYDPFDAQRVSQTDVFAGVKAMI 554

  Fly   567 LDLSSKYKTDGSRIAWVSIR--LPEQLSEPVDPQSWLLHASMYGPRQLLSLVVADLALPKLGLES 629
            .::..:|  ...:|.|:|::  :|.|:.                        :.|:...|..:::
Zfish   555 GEVEKRY--GDVKIPWISVKTEVPSQVK------------------------LMDIISKKHPVDT 593

  Fly   630 LVLLATPGMVFKADFLNRVRMNTIQGFQVYAPIGFQMY----------PCRWAHFCRECDTCDVS 684
            |..||:......||||||.|||.|..:||:.||.||.|          |...:.|..|      :
Zfish   594 LFFLASVWTEVNADFLNRCRMNAISNWQVFFPIHFQEYSPALVYRDQQPSAASSFASE------T 652

  Fly   685 QSSGYFDRHNHDVIAFYSRDYVQARKLLHPQGLPIIRSD-LDIDQLLLQPGEETRPPGVES--IL 746
            ...|:||||..:...||:.||:.||..:        .:| ||.|:||            ||  :.
Zfish   653 LRDGHFDRHVFEEACFYNADYMAARTKM--------AADILDNDELL------------ESMDVY 697

  Fly   747 DMFVAAQHSVHILRGVEP-----------NLRFGQDVRNHLARGGTLPQSVPERCGREQCIHLAS 800
            ::|| ....:|:.|.|||           |.||.:|:.:              ||.......|||
Zfish   698 EIFV-RYSGLHVFRAVEPALVQKYVHRECNPRFSEDIYH--------------RCVLSNLEGLAS 747

  Fly   801 RKQIGDAIIRYE 812
            |..:..|:...|
Zfish   748 RSHLAMALFEQE 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43313	NP_001285184.1	CHGN	254..804	CDD:283361	159/589 (27%)
chpf2	XP_001337205.1	Galactosyl_T	133..>272	CDD:304462	41/167 (25%)
chpf2	XP_001337205.1	CHGN	246..751	CDD:283361	159/589 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595286
Domainoid	1	1.000	193	1.000	Domainoid score	I3140
eggNOG	1	0.900	-	-		E1_KOG3708
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	290	1.000	Inparanoid score	I2782
OMA	1	1.010	-	-		QHG49343
OrthoDB	1	1.010	-	-		D331164at33208
OrthoFinder	1	1.000	-	-		FOG0003088
OrthoInspector	1	1.000	-	-		otm24677
orthoMCL	1	0.900	-	-		OOG6_106235
Panther	1	1.100	-	-	LDO	PTHR12369
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5739
SonicParanoid	1	1.000	-	-		X2057
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800