DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lic and map2k6

DIOPT Version :9

Sequence 1:	NP_477162.1	Gene:	lic / 32257	FlyBaseID:	FBgn0261524	Length:	334	Species:	Drosophila melanogaster
Sequence 2:	XP_021335833.1	Gene:	map2k6 / 65239	ZFINID:	ZDB-GENE-010202-3	Length:	416	Species:	Danio rerio

Alignment Length:	317	Identity:	188/317 - (59%)
Similarity:	243/317 - (76%)	Gaps:	0/317 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 PFTIAKEPEAAIVPPRNLDSRATIQIGDRTFDIDADSLEKICDLGRGAYGIVDKMRHKQTDTVLA 73
            |..:.::|..|..|||:|||:|.:.||::.|.:.||.||:|.:|||||||:||||||..:..::|
Zfish    98 PKEVFEKPAPAPTPPRDLDSKAYVTIGEKNFVVKADDLEQIGELGRGAYGVVDKMRHVPSGVIMA 162

  Fly    74 VKRIPMTVNIREQHRLVMDLDISMRSSDCPYTVHFYGAMYREGDVWICMEVMSTSLDKFYPKVFL 138
            ||||..|||.:||.||:||||||||:.||.|||.||||::||||||||||:|.|||||||.:|..
Zfish   163 VKRIRATVNTQEQKRLLMDLDISMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYKQVHE 227

  Fly   139 HDLRMEESVLGKIAMSVVSALHYLHAQLKVIHRDVKPSNILINRAGQVKICDFGISGYLVDSIAK 203
            ....:.|.:||||.:|:|.||.:||:.|.||||||||||:|||..||||:||||||||||||:||
Zfish   228 KGKTIPEDILGKITVSIVKALEHLHSNLSVIHRDVKPSNVLINMQGQVKMCDFGISGYLVDSVAK 292

  Fly   204 TIDAGCKPYMAPERIDPQGNPAQYDIRSDVWSLGIGMIEMATGRYPYDNWRTPFEQLRQVVEDSP 268
            |:|||||||||||||:|:.|...|:::||:|||||.|||:|..|:|||:|.|||:||:||||:..
Zfish   293 TMDAGCKPYMAPERINPETNQKGYNVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPS 357

  Fly   269 PRLPEGTFSPEFEDFIAVCLQKEYMARPNYEQLLKHSFIVEHLQRNTDISEFVARIL 325
            |:||...||.:|.||.:.||:|....||.|.:|::|.|...|..::||::.||..||
Zfish   358 PQLPADRFSADFVDFTSQCLRKNSTERPTYTELMQHPFFTLHDSKDTDVASFVKTIL 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lic	NP_477162.1	PKc_MKK3_6	44..326	CDD:173729	174/282 (62%)
map2k6	XP_021335833.1	PKc_MKK3_6	133..415	CDD:173729	174/282 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	350	1.000	Domainoid score	I986
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	398	1.000	Inparanoid score	I1903
OMA	1	1.010	-	-		QHG51923
OrthoDB	1	1.010	-	-		D470057at33208
OrthoFinder	1	1.000	-	-		FOG0001217
OrthoInspector	1	1.000	-	-		oto39763
orthoMCL	1	0.900	-	-		OOG6_101822
Panther	1	1.100	-	-	LDO	PTHR48013
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2221
SonicParanoid	1	1.000	-	-		X2955
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	13.010