DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lic and map2k4b

DIOPT Version :9

Sequence 1:	NP_477162.1	Gene:	lic / 32257	FlyBaseID:	FBgn0261524	Length:	334	Species:	Drosophila melanogaster
Sequence 2:	XP_021335830.1	Gene:	map2k4b / 568951	ZFINID:	ZDB-GENE-080721-13	Length:	501	Species:	Danio rerio

Alignment Length:	332	Identity:	168/332 - (50%)
Similarity:	230/332 - (69%)	Gaps:	13/332 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KEPEAAIVPPRNLDSRATIQIG-DRTFDIDADSLEKICDLGRGAYGIVDKMRHKQTDTVLAVKRI 77
            :.|....:...:::|...::|. ::..|..|:.|:.:.::||||||.|:.|.||.:..::|||||
Zfish   163 QNPHIERLRTHSIESSGKLKISPEQHCDFTAEDLKDLGEIGRGAYGSVNNMVHKPSGQIMAVKRI 227

  Fly    78 PMTVNIREQHRLVMDLDISMRSSDCPYTVHFYGAMYREGDVWICMEVMSTSLDKFYPKVF-LHDL 141
            ..||:.:||.:|:||||:.||||||||.|.||||::||||.|||||:|:|||||||..|: ..|.
Zfish   228 RSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMATSLDKFYKYVYCASDD 292

  Fly   142 RMEESVLGKIAMSVVSALHYLHAQLKVIHRDVKPSNILINRAGQVKICDFGISGYLVDSIAKTID 206
            .:.|.:||||.::.|.||::|...||:||||:||||||::|.|.:|:|||||||.||||||||.|
Zfish   293 VIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRNGNIKLCDFGISGQLVDSIAKTRD 357

  Fly   207 AGCKPYMAPERIDPQGNPAQYDIRSDVWSLGIGMIEMATGRYPYDNWRTPFEQLRQVVEDSPPRL 271
            |||:||||||||||..:...||:|||||||||.:.|:||||:||..|.:.|:||.|||:..||:|
Zfish   358 AGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPRWNSVFDQLTQVVKGEPPQL 422

  Fly   272 ---PEGTFSPEFEDFIAVCLQKEYMARPNYEQLL--------KHSFIVEHLQRNTDISEFVARIL 325
               .:..||.:|..|:.:||.|:...||.|.:||        ||.||:.:.:|..|::.:|.|||
Zfish   423 CSSEDRQFSHKFIQFVNLCLTKDESKRPKYRELLVRHTASVCKHPFILMYEERLVDVARYVCRIL 487

  Fly   326 DLPDAQP 332
            |...|.|
Zfish   488 DQMPASP 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lic	NP_477162.1	PKc_MKK3_6	44..326	CDD:173729	159/293 (54%)
map2k4b	XP_021335830.1	PKc_MKK4	190..487	CDD:270790	160/296 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51923
OrthoDB	1	1.010	-	-		D470057at33208
OrthoFinder	1	1.000	-	-		FOG0001217
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101822
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.830