Protein Alignment lic and MAP2K6

DIOPT Version :10

• Sequence 1: NP_477162.1
• Gene: lic / 32257
• FlyBaseID: FBgn0261524
• Length: 334
• Species: Drosophila melanogaster
• Sequence 2: XP_047292366.1
• Gene: MAP2K6 / 5608
• HGNCID: 6846
• Length: 337
• Species: Homo sapiens
• Alignment Length: 312
• Identity: 189/312 - (60%)
• Similarity: 243/312 - (77%)
• Gaps: 0/312 - (0%)

  Fly    14 KEPEAAIVPPRNLDSRATIQIGDRTFDIDADSLEKICDLGRGAYGIVDKMRHKQTDTVLAVKRIP 78
            ::|:.:..|||:|||:|.|.||::.|::.||.||.|.:|||||||:|:||||..:..::|||||.
Human    24 EQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIR 88

  Fly    79 MTVNIREQHRLVMDLDISMRSSDCPYTVHFYGAMYREGDVWICMEVMSTSLDKFYPKVFLHDLRM 143
            .|||.:||.||:||||||||:.|||:||.||||::||||||||||:|.|||||||.:|......:
Human    89 ATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTI 153

  Fly   144 EESVLGKIAMSVVSALHYLHAQLKVIHRDVKPSNILINRAGQVKICDFGISGYLVDSIAKTIDAG 208
            .|.:|||||:|:|.||.:||::|.||||||||||:|||..||||:||||||||||||:|||||||
Human   154 PEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAG 218

  Fly   209 CKPYMAPERIDPQGNPAQYDIRSDVWSLGIGMIEMATGRYPYDNWRTPFEQLRQVVEDSPPRLPE 273
            ||||||||||:|:.|...|.::||:|||||.|||:|..|:|||:|.|||:||:||||:..|:||.
Human   219 CKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPA 283

  Fly   274 GTFSPEFEDFIAVCLQKEYMARPNYEQLLKHSFIVEHLQRNTDISEFVARIL 325
            ..||.||.||.:.||:|....||.|.:|::|.|...|..:.||::.||..||
Human   284 DKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLIL 335

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lic	NP_477162.1	PKc_MKK3_6	44..326	CDD:173729	176/282 (62%)
MAP2K6	XP_047292366.1	PKc_MKK3_6	54..336	CDD:173729	176/282 (62%)