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Protein Alignment lic and MAP2K1

DIOPT Version :9

Sequence 1:	NP_477162.1	Gene:	lic / 32257	FlyBaseID:	FBgn0261524	Length:	334	Species:	Drosophila melanogaster
Sequence 2:	NP_002746.1	Gene:	MAP2K1 / 5604	HGNCID:	6840	Length:	393	Species:	Homo sapiens

Alignment Length:	373	Identity:	126/373 - (33%)
Similarity:	194/373 - (52%)	Gaps:	75/373 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KRHRLTPFTIAKEPEAAIVPPRNLDSRATIQIGDRTFDIDADSLEKICDLGRGAYGIVDKMRHKQ 67
            :|.||..|...|:                 ::|    ::..|..|||.:||.|..|:|.|:.||.
Human    46 QRKRLEAFLTQKQ-----------------KVG----ELKDDDFEKISELGAGNGGVVFKVSHKP 89

  Fly    68 TDTVLAVKRIPMTVNIREQHRLVMDLDISMRSSDCPYTVHFYGAMYREGDVWICMEVM-STSLDK 131
            :..|:|.|.|.:.:....:::::.:|.: :...:.||.|.||||.|.:|::.||||.| ..|||:
Human    90 SGLVMARKLIHLEIKPAIRNQIIRELQV-LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQ 153

  Fly   132 FYPKVFLHDLRMEESVLGKIAMSVVSALHYLHAQLKVIHRDVKPSNILINRAGQVKICDFGISGY 196
            ...|..    |:.|.:|||::::|:..|.||..:.|::||||||||||:|..|::|:||||:||.
Human   154 VLKKAG----RIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQ 214

  Fly   197 LVDSIAKTIDAGCKPYMAPERIDPQGNPAQYDIRSDVWSLGIGMIEMATGRYPY----------- 250
            |:||:|.:. .|.:.||:|||:  ||  ..|.::||:||:|:.::|||.||||.
Human   215 LIDSMANSF-VGTRSYMSPERL--QG--THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELM 274

  Fly   251 -------DNWRTP-----------------------FEQLRQVVEDSPPRLPEGTFSPEFEDFIA 285
                   |...||                       ||.|..:|.:.||:||.|.||.||:||:.
Human   275 FGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVN 339

  Fly   286 VCLQKEYMARPNYEQLLKHSFIVEHLQRNTDISEFVARILDLPDAQPA 333
            .||.|....|.:.:||:.|:||........|.:.::...:.|  .||:
Human   340 KCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGL--NQPS 385

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.