DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lic and map3k3

DIOPT Version :9

Sequence 1:	NP_477162.1	Gene:	lic / 32257	FlyBaseID:	FBgn0261524	Length:	334	Species:	Drosophila melanogaster
Sequence 2:	XP_688694.2	Gene:	map3k3 / 560211	ZFINID:	ZDB-GENE-070910-1	Length:	620	Species:	Danio rerio

Alignment Length:	270	Identity:	81/270 - (30%)
Similarity:	127/270 - (47%)	Gaps:	31/270 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 LGRGAYGIVDKMRHKQTDTVLAVKRIPMTVNIREQHRLVMDLDIS---MRSSDCPYTVHFYGAM- 112
            ||:||:|.|.......|...||.|::.......|..:.|..|:..   :::......|.:||.:
Zfish   362 LGQGAFGRVYLCYDVDTGRELAAKQVHFDPASPETSKEVSALECEIQLLKNLHHERIVQYYGCLR 426

  Fly   113 -YREGDVWICMEVMSTSLDKFYPKVFLHDLRMEESVLGKIAMSVVSALHYLHAQLKVIHRDVKPS 176
             :.|..:.|.||.|.....|...|.:   ..:.|:|..|....::..:.|||:.: ::|||:|.:
Zfish   427 DHNEKTLTIFMEYMPGGSVKDQLKAY---GALTENVTRKYTRQILEGMSYLHSNM-IVHRDIKGA 487

  Fly   177 NILINRAGQVKICDFGISGYL---------VDSIAKTIDAGCKPY-MAPERIDPQGNPAQYDIRS 231
            |||.:.||.||:.|||.|..|         |.|:..|      || |:||.|..:|    |..::
Zfish   488 NILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGT------PYWMSPEVISGEG----YGRKA 542

  Fly   232 DVWSLGIGMIEMATGRYPYDNWRTPFEQLRQVVEDSPPRLPEGTFSPEFEDFIAVCLQKEYMARP 296
            ||||||..::||.|.:.|:..:.......:...:.:.|:|| ...|....||:. |:..|...||
Zfish   543 DVWSLGCTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPQLP-SHISEHTRDFLR-CIFVEAKYRP 605

  Fly   297 NYEQLLKHSF 306
            :.|:||:|.|
Zfish   606 SAEELLRHPF 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lic	NP_477162.1	PKc_MKK3_6	44..326	CDD:173729	81/270 (30%)
map3k3	XP_688694.2	PB1_Mekk2_3	48..126	CDD:99726
		STKc_MEKK3_like	356..615	CDD:270795	80/268 (30%)
		S_TKc	356..615	CDD:214567	80/268 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579515
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930