DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lic and MAP3K4

DIOPT Version :9

Sequence 1:	NP_477162.1	Gene:	lic / 32257	FlyBaseID:	FBgn0261524	Length:	334	Species:	Drosophila melanogaster
Sequence 2:	NP_005913.3	Gene:	MAP3K4 / 4216	HGNCID:	6856	Length:	1608	Species:	Homo sapiens

Alignment Length:	300	Identity:	84/300 - (28%)
Similarity:	143/300 - (47%)	Gaps:	38/300 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 PRNLDSRATIQIGDRTFDIDADSLEKICDLGRGAYGIVDKMRHKQTDTVLAVKRIPMTVNIREQH 87
            |::.|:  .:.:|.|..........||   |.|.||.|.......|..::|:|.|....|   .|
Human  1325 PKSYDN--VMHVGLRKVTFKWQRGNKI---GEGQYGKVYTCISVDTGELMAMKEIRFQPN---DH 1381

  Fly    88 RLVMDLDISMRSSD---CPYTVHFYGAMYREGDVWICMEVMST-SLDKFYPKVFLHDLRMEESVL 148
            :.:.:....::..:   .|..|.::|......:::|.||.... :|::      :..|.::|.|:
Human  1382 KTIKETADELKIFEGIKHPNLVRYFGVELHREEMYIFMEYCDEGTLEE------VSRLGLQEHVI 1440

  Fly   149 GKIAMSVVSALHYLHAQLKVIHRDVKPSNILINRAGQVKICDFGISGYLVDSIAKTIDA------ 207
            ...:..:..|::.|| :..::|||:|.:||.:..:|.:|:.|||.|..|.:: |:|:..
Human  1441 RLYSKQITIAINVLH-EHGIVHRDIKGANIFLTSSGLIKLGDFGCSVKLKNN-AQTMPGEVNSTL 1503

  Fly   208 GCKPYMAPERI-----DPQGNPAQYDIRSDVWSLGIGMIEMATGRYPYDNWRTPFEQLRQVVEDS 267
            |...|||||.|     :..|..|      |:||||..:|||.||:.|:..:...|:.:.:|....
Human  1504 GTAAYMAPEVITRAKGEGHGRAA------DIWSLGCVVIEMVTGKRPWHEYEHNFQIMYKVGMGH 1562

  Fly   268 PPRLPEGTFSPEFEDFIAVCLQKEYMARPNYEQLLKHSFI 307
            .|.:|| ..|||.:||::.||:.:...|....|||.|||:
Human  1563 KPPIPE-RLSPEGKDFLSHCLESDPKMRWTASQLLDHSFV 1601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lic	NP_477162.1	PKc_MKK3_6	44..326	CDD:173729	80/278 (29%)
MAP3K4	NP_005913.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..136
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	429..478
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1157..1190
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1202..1231
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1244..1274
		STKc_MEKK4	1342..1601	CDD:270796	79/279 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145985
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930