DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lic and MAP3K3

DIOPT Version :9

Sequence 1:	NP_477162.1	Gene:	lic / 32257	FlyBaseID:	FBgn0261524	Length:	334	Species:	Drosophila melanogaster
Sequence 2:	NP_976226.1	Gene:	MAP3K3 / 4215	HGNCID:	6855	Length:	657	Species:	Homo sapiens

Alignment Length:	344	Identity:	91/344 - (26%)
Similarity:	148/344 - (43%)	Gaps:	61/344 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KRHRLTPFTIAK-------------------EPEAAIVPPRNLDSRATIQIGDRTFDIDADSLE- 47
            :||:...||:..                   :|...:   |:.||...:.:.:|.....:.|..
Human   330 RRHQGNLFTLVPSSRSLSTNGENMGLAVQYLDPRGRL---RSADSENALSVQERNVPTKSPSAPI 391

  Fly    48 -----KICDLGRGAYGIVDKMRHKQTDTVLAVKRIPMTVNIREQHRLVMDLDIS---MRSSDCPY 104
                 |:  ||:||:|.|.......|...||.|::....:..|..:.|..|:..   :::.....
Human   392 NWRRGKL--LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHER 454

  Fly   105 TVHFYGAM--YREGDVWICMEVMSTSLDKFYPKVFLHDLRMEESVLGKIAMSVVSALHYLHAQLK 167
            .|.:||.:  ..|..:.|.||.|.....|...|.:   ..:.|||..|....::..:.|||:.:
Human   455 IVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAY---GALTESVTRKYTRQILEGMSYLHSNM- 515

  Fly   168 VIHRDVKPSNILINRAGQVKICDFG---------ISGYLVDSIAKTIDAGCKPY-MAPERIDPQG 222
            ::|||:|.:|||.:.||.||:.|||         :||..:.|:..|      || |:||.|..:|
Human   516 IVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGT------PYWMSPEVISGEG 574

  Fly   223 NPAQYDIRSDVWSLGIGMIEMATGRYPYDNWRTPFEQLRQVVEDSPPRLPEGTFSPEFEDFIAVC 287
                |..::||||||..::||.|.:.|:..:.......:...:.:.|:|| ...|....||:. .
Human   575 ----YGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLP-SHISEHGRDFLR-R 633

  Fly   288 LQKEYMARPNYEQLLKHSF 306
            :..|...||:.|:||.|.|
Human   634 IFVEARQRPSAEELLTHHF 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lic	NP_477162.1	PKc_MKK3_6	44..326	CDD:173729	82/284 (29%)
MAP3K3	NP_976226.1	PB1_Mekk2_3	76..154	CDD:99726
MAP3K3	NP_976226.1	STKc_MEKK3_like	392..652	CDD:270795	80/277 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145986
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930