DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lic and Mkk4

DIOPT Version :9

Sequence 1:	NP_477162.1	Gene:	lic / 32257	FlyBaseID:	FBgn0261524	Length:	334	Species:	Drosophila melanogaster
Sequence 2:	NP_001163551.1	Gene:	Mkk4 / 41020	FlyBaseID:	FBgn0024326	Length:	424	Species:	Drosophila melanogaster

Alignment Length:	355	Identity:	170/355 - (47%)
Similarity:	234/355 - (65%)	Gaps:	31/355 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SKRHRLTPFTIAKEPE------AAIVPPRNLDSRAT----------------IQIGD---RTFDI 41
            |:.:.:|....|::|:      ::.|||....|.::                :|.|:   .|...
  Fly    53 SQHNHVTRCFGAQQPQQTPPVASSQVPPVPAASSSSAADRHRERIRQQACGKLQFGEGGANTHTF 117

  Fly    42 DADSLEKICDLGRGAYGIVDKMRHKQTDTVLAVKRIPMTVNIREQHRLVMDLDISMRSSDCPYTV 106
            .:|.||...::||||:|.|:||..|:.|.|:|||||..||:.:||.:|:|||::.|:|::|.|.|
  Fly   118 TSDDLEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTVDEKEQKQLLMDLEVVMKSNECIYIV 182

  Fly   107 HFYGAMYREGDVWICMEVMSTSLDKFYPKVFLHDLR-MEESVLGKIAMSVVSALHYLHAQLKVIH 170
            .||||:::|||.|||||:|.|||||||..::....| :.||:|.||.::.|:||:||..:||:||
  Fly   183 QFYGALFKEGDCWICMELMDTSLDKFYKYIYEKQQRHIPESILAKITVATVNALNYLKEELKIIH 247

  Fly   171 RDVKPSNILINRAGQVKICDFGISGYLVDSIAKTIDAGCKPYMAPERIDPQGNPAQYDIRSDVWS 235
            |||||||||::|.|.:|:|||||||.||||||||.||||:||||||||||: ....||:||||||
  Fly   248 RDVKPSNILLHRRGDIKLCDFGISGQLVDSIAKTKDAGCRPYMAPERIDPE-RAKGYDVRSDVWS 311

  Fly   236 LGIGMIEMATGRYPYDNWRTPFEQLRQVVEDSPPRLPEG----TFSPEFEDFIAVCLQKEYMARP 296
            |||.::|:|||.:||..|.:.||||.|||:..||||...    .||.||.||:..||.|:...||
  Fly   312 LGITLMEVATGNFPYRKWDSVFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRP 376

  Fly   297 NYEQLLKHSFIVEHLQRNTDISEFVARILD 326
            .|.:||:..||......:||::.:||.||:
  Fly   377 KYSRLLEMPFIRRGETSHTDVAVYVADILE 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lic	NP_477162.1	PKc_MKK3_6	44..326	CDD:173729	158/286 (55%)
Mkk4	NP_001163551.1	PKc_MKK4	115..405	CDD:270790	157/290 (54%)
Mkk4	NP_001163551.1	S_TKc	123..387	CDD:214567	149/264 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447168
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I927
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51923
OrthoDB	1	1.010	-	-		D108656at6656
OrthoFinder	1	1.000	-	-		FOG0001217
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101822
Panther	1	1.100	-	-	P	PTHR48013
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2221
SonicParanoid	0	0.000	Not matched by this tool.
	9	8.940