DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lic and Map3k3

DIOPT Version :9

Sequence 1:	NP_477162.1	Gene:	lic / 32257	FlyBaseID:	FBgn0261524	Length:	334	Species:	Drosophila melanogaster
Sequence 2:	NP_036077.1	Gene:	Map3k3 / 26406	MGIID:	1346874	Length:	626	Species:	Mus musculus

Alignment Length:	344	Identity:	90/344 - (26%)
Similarity:	148/344 - (43%)	Gaps:	61/344 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KRHRLTPFTIAK-------------------EPEAAIVPPRNLDSRATIQIGDRTFDIDADSLE- 47
            :||:...||:..                   :|...:   |:.||...:.:.:|.....:.|..
Mouse   299 RRHQGNLFTLVPSSRSLSTNGENMGVAVQYLDPRGRL---RSADSENALTVQERNVPTKSPSAPI 360

  Fly    48 -----KICDLGRGAYGIVDKMRHKQTDTVLAVKRIPMTVNIREQHRLVMDLDIS---MRSSDCPY 104
                 |:  ||:||:|.|.......|...||.|::....:..|..:.|..|:..   :::.....
Mouse   361 NWRRGKL--LGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQHER 423

  Fly   105 TVHFYGAMYREGD--VWICMEVMSTSLDKFYPKVFLHDLRMEESVLGKIAMSVVSALHYLHAQLK 167
            .|.:||.:....:  :.|.||.|.....|...|.:   ..:.|||..|....::..:.|||:.:
Mouse   424 IVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAY---GALTESVTRKYTRQILEGMSYLHSNM- 484

  Fly   168 VIHRDVKPSNILINRAGQVKICDFG---------ISGYLVDSIAKTIDAGCKPY-MAPERIDPQG 222
            ::|||:|.:|||.:.||.||:.|||         :||..:.|:..|      || |:||.|..:|
Mouse   485 IVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGT------PYWMSPEVISGEG 543

  Fly   223 NPAQYDIRSDVWSLGIGMIEMATGRYPYDNWRTPFEQLRQVVEDSPPRLPEGTFSPEFEDFIAVC 287
                |..::||||||..::||.|.:.|:..:.......:...:.:.|:|| ...|....||:. .
Mouse   544 ----YGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLP-SHISEHGRDFLR-R 602

  Fly   288 LQKEYMARPNYEQLLKHSF 306
            :..|...||:.|:||.|.|
Mouse   603 IFVEARQRPSAEELLTHHF 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lic	NP_477162.1	PKc_MKK3_6	44..326	CDD:173729	81/284 (29%)
Map3k3	NP_036077.1	PB1_Mekk2_3	45..123	CDD:99726
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	125..184
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	218..273
		STKc_MEKK3_like	361..621	CDD:270795	79/277 (29%)
		S_TKc	362..621	CDD:214567	79/276 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836068
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930