DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lic and Map2k6

DIOPT Version :9

Sequence 1:	NP_477162.1	Gene:	lic / 32257	FlyBaseID:	FBgn0261524	Length:	334	Species:	Drosophila melanogaster
Sequence 2:	XP_036012601.1	Gene:	Map2k6 / 26399	MGIID:	1346870	Length:	347	Species:	Mus musculus

Alignment Length:	329	Identity:	191/329 - (58%)
Similarity:	247/329 - (75%)	Gaps:	4/329 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSKRHRLTPFTIAKE----PEAAIVPPRNLDSRATIQIGDRTFDIDADSLEKICDLGRGAYGIVD 61
            :|.:.|.....|.||    |:.:..|||:|||:|.|.||::.|::.||.||.|.:|||||||:|:
Mouse    17 ISSKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIVELGRGAYGVVE 81

  Fly    62 KMRHKQTDTVLAVKRIPMTVNIREQHRLVMDLDISMRSSDCPYTVHFYGAMYREGDVWICMEVMS 126
            ||||..:..::|||||..|||.:||.||:||||:|||:.|||:||.||||::||||||||||:|.
Mouse    82 KMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDVSMRTVDCPFTVTFYGALFREGDVWICMELMD 146

  Fly   127 TSLDKFYPKVFLHDLRMEESVLGKIAMSVVSALHYLHAQLKVIHRDVKPSNILINRAGQVKICDF 191
            |||||||.:|......:.|.:|||||:|:|.||.:||::|.||||||||||:|||..||||:|||
Mouse   147 TSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINTLGQVKMCDF 211

  Fly   192 GISGYLVDSIAKTIDAGCKPYMAPERIDPQGNPAQYDIRSDVWSLGIGMIEMATGRYPYDNWRTP 256
            |||||||||:|||||||||||||||||:|:.|...|.::||:|||||.|||:|..|:|||:|.||
Mouse   212 GISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTP 276

  Fly   257 FEQLRQVVEDSPPRLPEGTFSPEFEDFIAVCLQKEYMARPNYEQLLKHSFIVEHLQRNTDISEFV 321
            |:||:||||:..|:||...||.:|.||.:.||:|....||.|.:|::|.|...|..:..|::.||
Mouse   277 FQQLKQVVEEPSPQLPADKFSADFVDFTSQCLKKNSKERPTYPELMQHPFFTVHESKAADVASFV 341

  Fly   322 ARIL 325
            ..||
Mouse   342 KLIL 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lic	NP_477162.1	PKc_MKK3_6	44..326	CDD:173729	173/282 (61%)
Map2k6	XP_036012601.1	PKc_MKK3_6	64..346	CDD:173729	173/282 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	354	1.000	Domainoid score	I989
eggNOG	1	0.900	-	-		E1_KOG0984
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	406	1.000	Inparanoid score	I1875
Isobase	1	0.950	-	0	Normalized mean entropy	S1024
OMA	1	1.010	-	-		QHG51923
OrthoDB	1	1.010	-	-		D470057at33208
OrthoFinder	1	1.000	-	-		FOG0001217
OrthoInspector	1	1.000	-	-		otm43056
orthoMCL	1	0.900	-	-		OOG6_101822
Panther	1	1.100	-	-	LDO	PTHR48013
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2221
SonicParanoid	1	1.000	-	-		X2955
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.820