DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lic and Map2k1

DIOPT Version :9

Sequence 1:	NP_477162.1	Gene:	lic / 32257	FlyBaseID:	FBgn0261524	Length:	334	Species:	Drosophila melanogaster
Sequence 2:	NP_113831.1	Gene:	Map2k1 / 170851	RGDID:	70495	Length:	393	Species:	Rattus norvegicus

Alignment Length:	373	Identity:	126/373 - (33%)
Similarity:	194/373 - (52%)	Gaps:	75/373 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KRHRLTPFTIAKEPEAAIVPPRNLDSRATIQIGDRTFDIDADSLEKICDLGRGAYGIVDKMRHKQ 67
            :|.||..|...|:                 ::|    ::..|..|||.:||.|..|:|.|:.||.
  Rat    46 QRKRLEAFLTQKQ-----------------KVG----ELKDDDFEKISELGAGNGGVVFKVSHKP 89

  Fly    68 TDTVLAVKRIPMTVNIREQHRLVMDLDISMRSSDCPYTVHFYGAMYREGDVWICMEVM-STSLDK 131
            :..|:|.|.|.:.:....:::::.:|.: :...:.||.|.||||.|.:|::.||||.| ..|||:
  Rat    90 SGLVMARKLIHLEIKPAIRNQIIRELQV-LHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQ 153

  Fly   132 FYPKVFLHDLRMEESVLGKIAMSVVSALHYLHAQLKVIHRDVKPSNILINRAGQVKICDFGISGY 196
            ...|..    |:.|.:|||::::|:..|.||..:.|::||||||||||:|..|::|:||||:||.
  Rat   154 VLKKAG----RIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQ 214

  Fly   197 LVDSIAKTIDAGCKPYMAPERIDPQGNPAQYDIRSDVWSLGIGMIEMATGRYPY----------- 250
            |:||:|.:. .|.:.||:|||:  ||  ..|.::||:||:|:.::|||.||||.
  Rat   215 LIDSMANSF-VGTRSYMSPERL--QG--THYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELL 274

  Fly   251 -------DNWRTP-----------------------FEQLRQVVEDSPPRLPEGTFSPEFEDFIA 285
                   |...||                       ||.|..:|.:.||:||.|.||.||:||:.
  Rat   275 FGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVN 339

  Fly   286 VCLQKEYMARPNYEQLLKHSFIVEHLQRNTDISEFVARILDLPDAQPA 333
            .||.|....|.:.:||:.|:||........|.:.::...:.|  .||:
  Rat   340 KCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGL--NQPS 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lic	NP_477162.1	PKc_MKK3_6	44..326	CDD:173729	117/323 (36%)
Map2k1	NP_113831.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		PKc_MEK1	62..380	CDD:270816	117/327 (36%)
		RAF1-binding	270..307		3/36 (8%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D688282at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920