Protein Alignment hep and SLK

DIOPT Version :10

• Sequence 1: NP_001368982.1
• Gene: hep / 32256
• FlyBaseID: FBgn0010303
• Length: 1294
• Species: Drosophila melanogaster
• Sequence 2: NP_055535.2
• Gene: SLK / 9748
• HGNCID: 11088
• Length: 1235
• Species: Homo sapiens
• Alignment Length: 970
• Identity: 206/970 - (21%)
• Similarity: 338/970 - (34%)
• Gaps: 284/970 - (29%)

  Fly   182 KLNINGRQYPTDINDLKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRTGNAEENKRILMDLDV 246
            |.::|    |.|..::  :|:||:|..|.|.|..:..::.:.|.|.: .|.:.||.:..::::|
Human    25 KRDLN----PEDFWEI--IGELGDGAFGKVYKAQNKETSVLAAAKVI-DTKSEEELEDYMVEID- 81

  Fly   247 VLKSHDCKYIVKCLGCFVRDPDVWICMELMS-MCFDKLLKLSKKPVPEQILGKVTVATVNALSYL 310
            :|.|.|...|||.|..|..:.::||.:|..: ...|.::...::|:.|..:..|...|::||:||
Human    82 ILASCDHPNIVKLLDAFYYENNLWILIEFCAGGAVDAVMLELERPLTESQIQVVCKQTLDALNYL 146

  Fly   311 KDKHGVIHRDVKPSNILIDERGNIKLCDFGISGRLVDSKANTRS-------AGCAAYMAPERI-- 366
            .| :.:||||:|..|||....|:|||.|||:|.:      |||:       .|...:||||.:
Human   147 HD-NKIIHRDLKAGNILFTLDGDIKLADFGVSAK------NTRTIQRRDSFIGTPYWMAPEVVMC 204

  Fly   367 -DPKKPKYDIRADVWSLGITLVELATARSPYEGCNTDFEVLTKVLDSEPPCLPYGEGYNFSQQFR 430
             ..|...||.:||||||||||:|:|....|:...| ...||.|:..||||.|  .:...:|..|:
Human   205 ETSKDRPYDYKADVWSLGITLIEMAEIEPPHHELN-PMRVLLKIAKSEPPTL--AQPSRWSSNFK 266

  Fly   431 DFVIKCLTKNHQDRPKYPELLAQPFI---------RIYESAKVDVPNWFQSIKDNRLRANGDPTL 486
            ||:.|||.||...|....:||..||:         .:...||.:|.   :.::|
Human   267 DFLKKCLEKNVDARWTTSQLLQHPFVTVDSNKPIRELIAEAKAEVT---EEVED----------- 317

  Fly   487 QRATATGSAIGSGAGSLAGSGSGSAGGAVKYGRATTYAGQSPTNPQKTIKPTQIPSYQQQQSQFF 551
                                                  |:.....::|.....||:.::..|...
Human   318 --------------------------------------GKEEDEEEETENSLPIPASKRASSDLS 344

  Fly   552 MQSATQ--LPQTTTTTPTATTNCFGGSGNGNGRGNGSGGSGNGSGSSSSASPLSPPSAGIGDLN- 613
            :.|:.:  |.|..         |...|.:.....:.|....| |...:.......|...:.|:|
Human   345 IASSEEDKLSQNA---------CILESVSEKTERSNSEDKLN-SKILNEKPTTDEPEKAVEDINE 399

  Fly   614 -----------RLYRKSPFMQRKLSNGSHHPHYKYNDESPKKESMFSSIGQSILRNLTTSPFSQK 667
                       .|:.::..::.           ...::.||.|::..:..|   ..:..:..|:.
Human   400 HITDAQLEAMTELHDRTAVIKE-----------NEREKRPKLENLPDTEDQ---ETVDINSVSEG 450

  Fly   668 KHNSTATTIP--LPHN----------NQTLITDAATAAAAAATATTPPNIAATVLTTTPTTTPTW 720
            |.|:...|:.  :.||          .|.:..:....:         ..|..|:|.|....:...
Human   451 KENNIMITLETNIEHNLKSEEEKDQEKQQMFENKLIKS---------EEIKDTILQTVDLVSQET 506

  Fly   721 RLPTENSQAYDSCDSSSNATTTTLNLGLSSPSPSLPRKQFPTESPTLQLTSQQQQQPQRLQP--- 782
            .....|.||.||            .:||                 |.:.|.::..:..:.|.
Human   507 GEKEANIQAVDS------------EVGL-----------------TKEDTQEKLGEDDKTQKDVI 542

  Fly   783 GNQSPIVLQRFYHQQNQLREKEAAERYQQQRQQPPVGVTSTNPFHSNYVPPPPSTHSTSSQSSTQ 847
            .|.|.::           ...|||:..|:..:.                    |...|.|....:
Human   543 SNTSDVI-----------GTCEAADVAQKVDED--------------------SAEDTQSNDGKE 576

  Fly   848 ST-CSQIAINPASISPSSGSGTGNMAGLGIGSAPASGLGAAGHFGAGGTGEQLQYQPLPIAAEAT 911
            .. ..|..||...:.|.:|         |....|...:........|...||           |.
Human   577 VVEVGQKLINKPMVGPEAG---------GTKEVPIKEIVEMNEIEEGKNKEQ-----------AI 621

  Fly   912 GTSPTLQSRSPEQQSDYGGNGNMVASKLSKLYARRQLLGQSSS-------SGASNSSLDGCSREQ 969
            .:|..:...:.|..:..|                 :.:.:|||       |..:::.......|.
Human   622 NSSENIMDINEEPGTTEG-----------------EEITESSSTEEMEVRSVVADTDQKALGSEV 669

  Fly   970 HDAGWFNTLAGAMKRQFATYVKTQLNSTATSPVASSMDRDQEPVHPQPPAYRSV-VNNGSGGKSY 1033
            .||....|.....|::....:|.:...|..|          :|..|||....|: :|:.||....
Human   670 QDASKVTTQIDKEKKEIPVSIKKEPEVTVVS----------QPTEPQPVLIPSININSDSGENKE 724

  Fly  1034 YYRTLSAASS-----SSNTSQ--------STSPTTEPLPGGGTSSFLRRYASSGPGGSIS 1080
            ...:||...:     |.|..:        ||:.|:........||||.:...|   ||||
Human   725 EIGSLSKTETILPPESENPKENDNDSGTGSTADTSSIDLNLSISSFLSKTKDS---GSIS 781

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hep	NP_001368982.1	PKc_MKK7	181..476	CDD:270791	104/313 (33%)
SLK	NP_055535.2	STKc_SLK	28..309	CDD:270811	101/298 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	309..351		8/93 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	363..393		4/30 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	421..441		4/33 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	519..539		4/36 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	613..760		34/184 (18%)
		PKK	852..990	CDD:463600
		PKK	1020..1160	CDD:463600